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A & I Fellowship - Faculty

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Research Faculty

Center for Allergy And Inflammation
Allergy Section, Division Of Allergy And Infectious Diseases
University of Washington

  • William R Henderson Jr., MD
    Director, University of Washington A&I Program
    • Research: Mechanisms of airway inflammation and remodeling in animal models of asthma and pulmonary fibrosis; leukotriene biology.
  • Karol Bomsztyk, MD, Molecular links between signal transduction pathways and events that compose inducible gene expression. Development of advanced biotechnologies to define how chromatin dynamics and transcriptional processes are regulated.

Center for Lung Biology
Pulmonary And Critical Care Medicine
Department of Medicine, University of Washington

  • William Alteimeier, MD, Determinants of the spatial distribution of ventilation, mechanisms of ventilation-perfusion matching, and moduclation of the transcriptional response to Inflammation by mechanical ventilation.
  • Teal S. Hallstrand, MD, MPH, Immunopathogenesis of asthma through translational human studies and in vitro models using primary human cells. Airway epithelial regulation of eicosanoids and other proinflammatory mediators.
  • William C. Parks, PhD, Innate immune functions conferred by the epithelium focusing on three epithelial matrix metalloproteinases-matrilysin (MMP-7), stromelysin-2 (MMP-10), and epilysin (MMP-28) and how these secreted enzymes function in defense and repair.
  • Lynn Schnapp, MD, Mouse models of lung injury to examine the regulation of matrix remodeling and the role of the alveolar myofibroblasts in the resolution of fibrosis. Proteomic analysis of bronchoalveolar lavage fluid from patients with acute lung injury and other lung diseases to identify new pathways in lung injury.

Department of Immunology
School of Medicine, University of Washington

UW A&I fellows are able to train with any of more than thirty faculty who participate as mentors in immunology research training.

Immunology faculty include:

  • Alan A. Aderem, Mechanisms of phagocytosis and cell movement; macrophage development and differentiation.
  • Michael J. Bevan, T-lymphocyte differentiation in the thymus and positive selection of the receptor repertoire; the T-cell response to viral and bacterial infection; antigen processing and presentation.
  • Daniel Campbell, Lymphocyte homing and function; regulatory T cell localization; effector lymphocyte differentiation; tolerance in transplantation and autoimmunity.
  • Edward A. Clark, Regulation of B-cell and dendritic cell survival and death; molecules regulating germinal center formation.
  • Keith Elkon, Mechanisms of autoimmune disease; role of apoptosis in tolerance and autoimmunity.
  • Andrew G. Farr, Thymic stromal cell development; definition of nonlymphoid elements in the thymic environment.
  • Pamela J. Fink, The induction of tolerance among mature T cells in a T-cell receptor transgenic mouse model system; reverse signaling through Fas L as a positive regulator of T-cell proliferation and maturation.
  • Michael Gale, Jr., Virus-host interactions that control innate defenses and immunity to infection; genetic and functional analysis of the innate immune antiviral response; interferon biology; immune control of the replication and pathogenesis of hepatitis C virus and human immunodeficiency virus.
  • Joan M. Goverman, Autoimmune disease and mechanisms of acquiring immunological tolerance to self antigens.
  • Philip Greenberg, T-cell responses to infectious viruses and transformed cancer cells; immunobiology and pathogenesis of HIV; modification of T cells for adoptive therapy by gene insertion; signal transduction by cytokine receptors.
  • Lynn Hajjar, Innate immune recognition of microbial pathogens by Toll-like receptors.
  • Jessica Hamerman, Macrophage and dendritic cell activation, macrophage and dendritic cell responses to infection with bacteria and viruses, regulation of inflammatory responses.
  • Leroy Hood, Molecular recognition, autoimmune disease, tolerance, and the differentiation of T cells.
  • William Kwok, Uses of HLA class II tetramers to probe CD4+ T cell responses in various disease settings in humans.
  • Michael Lagunoff, Molecular virology of Kaposi's Sarcoma-associated herpesvirus (KSHV or HHV-8) and host cell responses to infection of B-cells and endothelial cells.
  • Yvette Latchman, Costimulatory pathways:role in autoimmunity and tumor responses.
  • Dennis Lindell, Modeling allergic lung disease including the role for B cells and regulatory T cells; development of novel RSV vaccines.
  • Nancy Maizels, Immunoglobulin gene class switch recombination and somatic hypermutation in activated B cells; mammalian DNA repair, genomic instability.
  • Carol Miao, Non-viral gene therapy for hemophilia; and modulation of immune responses in gene therapy treated animals.
  • Gerald T. Nepom, Molecular and genetic mechanisms contributing to triggering autoimmune disorders, in particular, the role of HLA class II genes.
  • Hans Ochs, Genetic and molecular basis of primary immunodeficiency disorders. Autosomal recessive hyper IgM syndrome and the scurfy gene, FOXP3, responsible for immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome.
  • Mohamed Oukka, Regulatory T and TH17 T cells in immune responses and autoimmune disorders including multiple sclerosis, systemic lupus, and inflammatory bowel disease.
  • Lalita Ramakrishnan, Bacterial pathogenesis; bacterial persistence; granuloma; host resistance to tuberculosis.
  • David Rawlings, Dysregulated B cell development and signaling leading to immunodeficiency, autoimmunity, or lymphoid malignancies; Gene therapy or gene repair for primary immunodeficiency disorders including X-linked agammaglobulinemia (XLA), Wiskott-Aldrich Syndrome (WAS) and SCID.
  • Helena Reijonen, Characterization of autoantigen specific T cell responses, mechanisms of the MHC class II mediated predisposition and protection in autoimmune diabetes.
  • Andrew Scharenberg, Signal transduction mechanisms and cation channel function in the immune system; Gene repair for primary immunodeficiency.
  • Daniel B. Stetson, Nucleic acid detection in host defense and autoimmunity; biology of antiviral responses.
  • Anne Stevens, Role of microchimerism in autoimmune diseases, altered lymphocyte function in systemic lupus, and human T cell function post-thymectomy.
  • Roland K. Strong, Structural immunology: the analysis of the functions of proteins and protein/receptor complexes mediating immune responses through the study of their structures by molecular biology, solution biochemistry and x-ray crystallography.
  • Troy Torgerson, Identification of basic cellular mechanisms that jointly promote autoimmunity and immunodeficiency. Molecular basis of immune dysregulation in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX).
  • Amy Weinmann, Mechanisms of transcriptional regulation in the immune system; cell-type specificity of transcription factors.
  • Thomas Wight, Role of proteoglycans, versican and hyaluronan in vascular diseases and lung diseases such as asthma
  • Steven Ziegler, Genetic and molecular analysis of immune system regulation; mechanisms of cytokine-mediated signal transduction; use of mouse mutants to uncover novel regulatory pathways.

Northwest Asthma and Allergy Center (NAAC)

NAAC is a multi-center, private allergy and immunology practice in the State of Washington (main office Seattle with satellite clinics throughout the Puget Sound region) whose physicians are also Directors of ASTHMA, Inc., a non-profit organization founded in 1972 to investigate new treatments in allergy, asthma, and immunology. Since 1972, ASTHMA, Inc., has conducted more than 500 FDA-approved clinical research trials. Stephen A Tilles, MD is Head of Research at ASTHMA, Inc. A&I fellows rotating at NAAC have the opportunity to become sub-investigators on all ASTHMA, Inc. clinical research trials in allergy and immunology. They receive an orientation on the operational structure of the site, are expected to perform periodic interviews and physical examinations of study subjects, and they have the opportunity to have additional extensive hands-on experience as their interest and time availability permits.

The following two UW clinical faculty members at NAAC are also engaged in allergy translational research:

  • Stephen A Tilles, Retrospective chart review of patients with vocal cord dysfunction (VCD) seen at Northwest Asthma and Allergy Center.
  • Leonard C Altman, Utility of versican and hyaluronan measurements in induced sputum as biomarkers of asthma.

 

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