Research training will beoffered in nine areas of special emphasis, representing the principal strengths of our faculty. Each track offers the trainee a variety of well-developed and well-funded research programs from which to choose. The Division of Allergy and Infectious Diseases also provides fellows with research opportunities in conjunction with basic science departments in areas of bacterial pathogenesis, immunology, molecular virology, and parasitology.

Tracks:

1. Pathogenesis of Viral Diseases
2. Pathogenesis of Bacterial, Fungal and Parasitic Diseases
3. Infectious Disease Immunology
4. Sexually Transmitted Diseases
5. Human Immunodeficiency Virus Infection
6. Leukocyte Biology and Function
7. Immunocompromised Host
8. Clinical Epidemiology of Infectious Diseases
9. Clinical Trials


Track 1: Pathogenesis of Viral Diseases

Michael Boeckh, M.D.
Lawrence Corey, M.D.
Michael Emerman, Ph.D.
Denise Galloway, Ph.D.
Adam Geballe, M.D.
David Gretch, M.D.
Michael Katze, Ph.D.
David Koelle, M.D.
Jasiri Lingappa, M.D., Ph.D.
James Mullins, Ph.D.
Kathy Neuzil
Julie Overbaugh, Ph.D.
Joe Zunt

Track 1 Offers an integrated interdisciplinary group of faculty for training in virology, with research activities ranging from basic molecular virology, to immunologic aspects of viral diseases, to the clinical epidemiology, prevention, and treatment of viral diseases. Expertise is especially concentrated in viral STDs, retroviruses, and viral infections of the immunocompromised host.


Track 2: Pathogenesis of Bacterial Fungal and Parasitic Diseases

Fred Buckner, M.D.
Jane Burns, M.D.
Caroline Cameron, Ph.D.
Arturo Centurion-Lara, M.D.
Patrick Duffy, M.D.
Ferric Fang, M.D.
David Fredricks, M.D.
Thomas Hawn
Mary Lampe, Ph.D.
Sheila Lukehart, Ph.D.
Kieren Marr, M.D.
Christina Marra, M.D.
Barbara Menzies
Samuel Miller, M.D.
Steve Moseley, Ph.D.
Dorothy Patton, Ph.D.
Lalita Ramakrishnan, M.D.
Craig Rubens, M.D., Ph.D.
Carol Sibley, Ph.D.
Walter Stamm, M.D.
Ann Stapleton, M.D.
Patricia Totten, Ph.D.
Wesley VanVoorhis, M.D., Ph.D.

Track 2  Emphasizes molecular studies of the virulence determinants integral to bacterial and parasite pathogenesis. Of special interest are mechanisms of attachment and cellular invasion in Escherichia coli, Pseudomonas aeruginosa, Group B streptococci, Salmonella, Chlamydia trachomatis, Haemophilus ducreyi, and Treponema pallidum infections. Potential drug targets and drug-development are being pursued for Trypanosoma cruzi, Trypanasoma brucei, Leishmania spp., and Plasmodium falciparum.


Track 3: Infectious Disease Immunology

Alan Aderem, Ph.D.
Michael Bevan, Ph.D.
Philip Greenberg, M.D., Ph.D.
Thomas Hawn
David Koelle, M.D.
Sheila Lukehart, Ph.D.
Juliana McElrath, M.D., Ph.D.
Wesley VanVoorhis, M.D., Ph.D.
Christopher Wilson, M.D.

Track 3  Provides training opportunities in laboratories studying the immunobiology and immunogenetics of host cell responses to infectious agents, especially Treponema pallidum, CMV, HIV, other retroviruses, HSV, Chlamydia, and Listeria. Particular emphasis is placed on elucidating the roles of innate immunity, specific cytokines, and T cell subsets in these infections.


Track 4: Sexually Transmitted Diseases

Caroline Cameron, Ph.D
Connie Celum, M.D., M.P.H.
Arturo Centurion-Lara, M.D.
Lawrence Corey, M.D.
David Fredricks, M.D.
Denise Galloway, Ph.D.
Matt Golden, M.D.
Hunter Handsfield, M.D.
King Holmes, M.D., Ph.D.
Mari Kitahata, M.D., M.P.H.
Nancy Kiviat, M.D.
David Koelle
Larua Koutsky, Ph.D.
Mary Lampe, Ph.D.
Sheila Lukehart, Ph.D.
Jeanne Marrazzo, M.D., M.P.H.
Dorothy Patton, Ph.D.
Walter Stamm, M.D.
Patricia Totten, Ph.D.
Wesley VanVoorhis, M.D., Ph.D.
Anna Wald, M.D.


Track 4 Offers a multi-disciplinary approach to the study of sexually transmitted infections, ranging from clinical and epidemiological studies in the United States and developing countries, to molecular pathogenesis and immune responses to STD pathogens. Organisms of particular interest include Chlamydia trachomatis, Treponema pallidum, herpes simplex virus, human papilloma virus, and Haemophilus ducreyi.

Track 5: Human Immunodeficiency Virus Infection

Connie Celum, M.D., M.P.H.
Ann Collier, M.D.
Robert Coombs, M.D., Ph.D.
Lawrence Corey, M.D.
Michael Emerman, Ph.D.
Carey Farquhar, M.D.
Matt Golden, M.D.
Philip Greenberg, M.D., Ph.D.
Hunter Handsfield, M.D.
Robert Harrington, M.D.
King Holmes, M.D.
Thomas M. Hooton, M.D.
Grace John-Stewart, M.D., M.P.H.
Seymour Klebanoff, M.D., Ph.D.
Christina Marra, M.D.
R. Scott McClelland, M.D.
Juliana McElrath, M.D., Ph.D.
James Mullins, Ph.D.
Julie Overbaugh, Ph.D.
Stanley Riddell, M.D.
David Spach, M.D.
Judith Wasserheit, M.D., M.P.H.
Joseph Zunt

Track 5 Provides a wide range of opportunities to investigate the epidemiology, natural history, immunology, molecular virology, and clinical care of patients with HIV infection. NIH-sponsored AIDS Clinical Trials and AIDS Vaccine Evaluation Units are located at the University of Washington, as well as a Fogarty program for international AIDS investigation and training.


Track 6: Leukocyte Biology and Function

Thomas Hawn, M.D.
William Henderson, M.D.
Seymour Klebanoff, M.D., Ph.D.
Henry Rosen, M.D.

Track 6 Investigators focus on the mechanisms by which phagocytes recognize and kill microorganisms. The roles of mast cells and eosinophils in allergic responses and infectious diseases are also being studied, as is the role of apoptosis. Another area of emphasis is the role and function of phagocytes in acute inflammation and tissue injury.


Track 7: Immunocompromised Host

Michael Boeckh, M.D.
Robert Coombs, M.D., Ph.D.
Lawrence Corey, M.D.
David Fredricks, M.D.
Adam Geballe, M.D.
Philip Greenberg, M.D., Ph.D.
David Gretch, M.D., Ph.D.
Kieren Marr, M.D.
Stanley Riddell, M.D.
Ted White, Ph.D.

Track 7 Provides a wide variety of research opportunities through the Fred Hutchinson Cancer Research Center and the Seattle Cancer Care Alliance, the world's largest marrow transplant center. Studies range from the molecular biology of viral pathogens in transplant patients, especially CMV, HSV, and HCV, to clinical studies of the epidemiology, treatment, and prevention of CMV and fungal infections. Multiple collaborations between faculty in this track and those in the virology and immunology tracks foster interdisciplinary investigative opportunities.  


Track 8: Clinical Epidemiology of Infectious Diseases

Connie Celum, M.D., M.P.H.
Lawrence Corey, M.D.
Jeffrey S. Duchin, M.D.
Carey Farquhar, M.D.
H. Hunter Handsfield, M.D.
Thomas Hawn, M.D.
King Holmes, M.D., Ph.D.
Thomas M. Hooton, M.D.
Grace John Stewart, M.D., M.P.H.
Mari Kitahata, M.D., M.P.H.
Larua Koutsky, Ph.D.
Ajit Limaye, M.D.
Jeanne Marrazzo, M.D., M.P.H.
R. Scott McClelland, M.D.
Kathleen Neuzil, M.D., M.P.H.
Walter Stamm, M.D.
Anna Wald, M.D., M.P.H.
Joseph Zunt

Track 8 Investigators are utilizing epidemiologic techniques to study the incidence, prevalence, and risk factors associated with various infections, especially STDs, HIV, sepsis, and urinary tract infections. A hallmark of these studies is close interaction with laboratory collaborators in order to utilize molecular epidemiologic techniques or study patient materials at the molecular and cellular level.


Track 9: Clinical Trials

Connie Celum, M.D., M.P.H..
Ann Collier, M.D.
King Holmes, M.D., Ph.D.
Thomas Hooton, M.D.
Kieren Marr, M.D.
Kathleen Neuzil, M.D., M.P.H.
Walter Stamm, M.D.
Anna Wald, M.D., M.P.H.
Judith Wasserheit, M.D.

In Track 9, Interactions between clinical and laboratory investigators are utilized in the context of controlled clinical trials. Studies focus principally on STDs, urinary tract infections, and infections of the immunocompromised host. The expertise of highly experienced biostatisical faculty is available to trainees in this track.