Andy Chien, MD, phd
Assistant Professor, Division of Dermatology
University of Washington
Seattle, WA 98195-8056
Education and Training
B.S., Biology, Johns Hopkins University, Baltimore, MD, 1991
M.D., Ph.D., Northwestern University, Chicago & Evanston, IL, 1999
Dermatology Residency, University of Washington, 2002 – 2005
Dr. Chien's research is centered on the study of signal transduction in melanoma and other cancer models. His recent work has focused on the role of both canonical Wnt/beta-catenin signaling in melanoma as well as the role of beta-catenin-independent Wnt signaling. His main interests center on regulation of these pathways in cancerous versus non-cancerous conditions, as well as the role of these pathways in regulating tumor initiating capacity in cancer cells.
More recently, his group has started studying how these signal transduction pathways are impacted during cancer therapy and the development of resistance.The goal of these studies is to develop strategies for pathway-based diagnostics and therapeutic targeting in melanoma and other cancers where conventional chemotherapeutic approaches have been ineffective.Dr. Chien has ongoing collaborations with clinical investigators at the Seattle Cancer Care Alliance who treat metastatic melanoma patients in the context of clinical trials.