Philip Fleckman, MD


Professor, Division of Dermatology

Contact Information

Acting Chief, VA Puget Sound Health Care System, Seattle
Box 358280
Seattle, WA 98195-8280

University of Washington
Box 356524
Seattle, WA 98195-6524
Office: 206-543-5290
Fax: 206-543-2489

Clinic Appointments: 206-598-4067
Clinic Fax: 206-598-2267

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Education and Training

M.D., Washington University School of Medicine, 1973
Internship in Medicine at Barnes Hospital, 1973-74
Postdoctoral fellowship in the USPHS, NIMH, NIH, Bethesda, MD, 1974-78
Residency in Dermatology, Yale University School of Medicine, 1978-80

Research Interests

Developmental biology of the distal digit. Healing skin around percutaneous devices. The pathophysiology of the ichthyoses. Most of these studies focus on in vitro models of epidermis.

Clinical Research Interests

General dermatology with special interest in individuals with inherited disorders of keratinization, with nail disorders, and with blistering skin disorders. Dr. Fleckman is the Principal Investigator of the National Registry for Ichthyosis and Related Disorders, an NIH-sponsored research registry for individuals with disorders of keratinization, and is the editor emeritus of the Dermatology Online Journal.

Representative Publications

Chan A, Godoy-Gijon E, Nuno-Gonzalez A, Crumrine D, Hupe M, Choi E-H, Gruber R, Williams ML, Fleckman P, Elias PM: Cellular basis for secondary infections and impaired desquamation in certain inherited ichthyoses. JAMA Dermatol 151:285, 2015. PMID 25565224

Coleman NW, Fleckman P, Huang JI. Fungal nail infections. J Hand Surg Am 39(5):985-8. 2014 doi: 10.1016/j.jhsa.2013.11.017. PMID: 24766830

Kazem S, van der Meijden E, Wang RC, Rosenberg AS, Pope E, Benoit T, Fleckman P, Feltkamp MCW. Polyomavirus-associated trichodysplasia spinulosa involves hyperproliferation, pRB phosphorylation and upregulation of p16 and p21. PLOS One, 2014, Oct 7;9(10):e108947. doi: 10.1371/journal.pone.0108947. eCollection 2014. PubMed PMID: 25291363.

Usui ML, Underwood RA, Fleckman P, Olerud JE. Parakeratotic Corneocytes Play a Unique Role in Human Skin Wound Healing. J Invest Dermatol 13:856-858, 2013 [2012 Sep 27 Epub ahead of print]. PMID 23014344, PMC3532577.

Fleckman P, Jaeger K, Silva K, Sundberg JP. Comparative Anatomy of Mouse and Human Nail Units. Anat Rec (Hoboken) 296(3):521-32, 2013. PMID 23408541, PMC3579226.

Zhao G, Usui ML, Lippman SI, James GA, Stewart PS, Fleckman P, Olerud JE: Biofilms and Chronic Wounds. Adv Wound Care 2:389-399, 2013. PMID 24527355, PMC3763221.

Fleckman P, Newell BD, van Steensel MA, Yan AC: Topical Treatment of the Ichthyoses. Dermatol Ther, Jan;26(1):16-25, 2013. PMID 23384017.

Di Chiacchio N, de Farias CD, Piraccini:BM, Hirata SH, Richert B, Zaiac M, Daniel R, Fanti PA, Andre J, Ruben BS, Fleckman P, Rich P, Haneke E, Chang P, Cherit JD, Scher R, Tosti A: Consenso sobre dermatoscopia da placa ungueal em melanoniquias (Consensus on melanonychia nail plate dermoscopy). An Bras Dermatol 88:309-313, 2013. PMID 23739699.

Secor PR, Jennings LK, James GA, Kirker KR, Pulcini ED, McInnerney K, Gerlach R, Livinghouse T, Hilmer JK, Bothner B, Fleckman P, Olerud JE, Stewart PS. Phevalin (aureusimine B)production by Staphylococcus aureus biofilm and impacts on human keratinocyte gene expression. PLoS One. 2012;7(7):e40973. Epub 2012 Jul 13. PMID 22808288, PMC3396627.

Fleckman P, DiGiovanna JD: The ichthyoses. IN Fitzpatrick’s Dermatology in General Medicine. Goldsmith LA, Katz SI, Gilchrest B, Paller AS, Leffell DJ, Wolff K eds, 8th edn. McGraw Hill, New York, 507-538, 2012.

Sundberg JP, Nanney LB, Fleckman P, King LE: Skin and adnexa. IN Comparative anatomy and histology. A mouse and human atlas. Treuting PM, Dintzis SM, eds. Elsevier, Amsterdam, 2012.

Fuchs-Telem D, Sarig O, van Steensel MAM, Isakov O, Israeli S, Nousbeck J, Winnepenninckx V, Shomron N, Uitto J, Fleckman P, Richard G, Eli Sprecher E: Familial pityriasis rubra pilaris is caused by mutations in CARD14. Am J Hum Genet 91:163-170, 2012. PMID 22703878, PMC3397268.

Zhao G, Usui ML, Underwood RA, Singh PK, James GA, Stewart PS, Fleckman P, Olerud JE: Time Course Study of Delayed Wound Healing in a Biofilm-Challenged Diabetic Mouse Model. Wound Repair Regen 20:342-352, 2012. PMID 22564229, PMC3349451.

Kazem S, van der Meijden E, Kooijman S, Rosenberg A, Hughey L, Browning JC, Sadler G, Busam K, Pope E, Benoit MT, Fleckman P, de Vries E, Eekhof J, Feltkamp M: Trichodysplasia spinulosa in immunocompromized patients is characterized by active polyomavirus infection. J Clin Virol 53:225-230, 2012. PMID 22196870.

Fleckman P
, Usui M, Zhao G, Underwood R, Maginness M, Marshall A, Glaister C, Ratner B, Olerud J: Cutaneous and inflammatory response to long-term percutaneous implants of porous/solid poly(HEMA) and silicone in mice. J Biomed Mater Res A 100:1256-1268, 2012. PMID 22359383, PMC3506026.

Underwood R, Usui M, Zhao G, Hauch K, Takeno M, Ratner B, Marshall A, Shi X, Olerud J, Fleckman P: Quantifying the effect of pore size and surface treatment on epidermal incorporation into percutanteously implanted sphere-templated porous biomaterials in mice. J Biomed Mat Res 98(4):499-508, 2011. PMID 216819452

Yeh I, George E, Fleckman P: Eccrine hidiradenitis sine neutrophiles: a toxic response to chemotherapy. J Cutan Pathol 38:905-10, 2011. PMID 21955315

Rajpopat S, Moss C, Mellerio JE, Vahlquist A, Ganemo A, Hellstrom-Pigg M, Ilchyshyn A, Burrows NP, Lestringant GG, Taylor AE, Kennedy CT, Paige DG, Harper JI, Glover M, Fleckman P, Everman D, Fouani MH, Kayserili H, Purvis DJ, Hobson EE, Chu CE, Mein CA, Kelsell DP, O’Toole EA: Harlequin ichthyosis: a review of clinical and molecular findings in 45 cases. Arch Dermatol 147:681-6, 2011. Epub ahead of print, 21 Feb 2011. PMID 21339420

Gruber R, Elias PM, Crumrine D, Lin T-K, Brandner J, Hachem J-P, Presland RB, Fleckman P, Janecke AR, Sandilands A, McLean WHI, Fritsch PO, Mildner M, Tschachler E, Schmuth M: Filaggrin genotype in ichthyosis vulgaris predicts dose-dependent abnormalities in epidermal structure and function. Am J Pathol 178:2252-2263, 2011. PMID 21514438, PMC3081164

Oji V, et al: Revised nomenclature and classification of inherited ichthyoses: Results of the First Ichthyosis Consensus Conference in Sorèze 2009. J Am Acad Dermatol 63:601-641, 2010. PMID 19349982

Petek LM, Fleckman P, Miller DG. Efficient KRT14 targeting and functional characterization of transplanted human keratinocytes for the treatment of epidermolysis bullosa simplex. Mol Ther 18:1624-1632, 2010, Epub ahead of print Jun 22. PMID 20571545, PMC2956915

Zhao G, Hochwalt PC, Usui ML, Underwood RA, Singh PK, James GA, Stewart PS, Fleckman P, Olerud JE. Delayed wound healing in diabetic (db/db) mice with pseudomonas aeruginosa biofilm challenge – A model for the study of chronic wounds. Wound Repair Regen 18:467-477, 2010. PMID 20731798, PMC2939909

Fallon PG, Sasaki T, Sandilands A, Campbell LE, Saunders SP, Mangan NE, Callanan JJ, Kawasaki H, Shiohama A, Kubo A, Sundberg JP, Presland RB, Fleckman P, Shimizu N, Kudoh J, Irvine AD, Amagai M, McLean WHI: A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming. Nat Genet 41:602-8 2009. Eprint ahead of publication 6 April.

Fleckman P
, Olerud JE: Models for the histologic study of the skin interface with percutaneous biomaterials. Biomed Mater 034006, 2008. PMID: 18708704.

Farasat S, Wei MH, Liewehr DJ, Steinberg SM, Bale SJ, Fleckman P, Toro JR: Transglutaminase-1 and genotype-phenotype investigations of 104 patients with autosomal recessive congenital ichthyosis the United States. J Med Genet 46:103-111, 2008. PMID 18948357 PMC3044481.

Isenhath SN, Fukano Y, Usui ML, Underwood RA, Irvin CA, Marshall AJ, Hauch KD, Ratner BD, Fleckman P, Olerud JE: A mouse model to evaluate the interface between skin and a percutaneous device. J Biomed Mater Res A 83A:915-922, 2007. PMID 17567856.

Smith FJD, Irvine AD, Terron-Kwiatkowski A, Sandilands A, Campbell LE, Zhao Y, Liao H, Evans AT, Goudie DR, Lewis-Jones S, Arseculeratne G, Munro CS, Sergeant A, O’Regan G, Bale SJ, Compton JG, DiGiovanna JJ, Presland RB, Fleckman P, McLean WHI: Loss-of-function mutations in the filaggrin gene cause ichthyosis vulgaris. Nat Genet 38:337-342, 2006. PMID 16444271.

Allan CH, Fleckman P, Fernandes RJ, Hager B, James J, Wisecarver Z, Satterstrom FK, Gutierrez A, Norman A, Pirrone A, Underwood RA, Rubin BP, Zhang M, Ramay HR, Clark JM. Tissue response and Msx1 expression after human fetal digit tip amputation in vitro. Wound Repair Regen 14:398-404, 2006. PMID 16939566.

For a complete listing of all publications, please email

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