Philip Fleckman, MD

Fleckman

Professor, Division of Dermatology
Acting Division Head

Contact Information

University of Washington
Box 356524
Seattle, WA 98195-6524
Office: 206-543-5290
Fax: 206-543-2489
fleck@uw.edu

Clinic Appointments: 206-598-4067
Clinic Fax: 206-598-2267

 

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Education and Training

M.D., Washington University School of Medicine, 1973
Internship in Medicine at Barnes Hospital, 1973-74
Postdoctoral fellowship in the USPHS, NIMH, NIH, Bethesda, MD, 1974-78
Residency in Dermatology, Yale University School of Medicine, 1978-80

Research Interests

Developmental biology of the distal digit. Healing skin around percutaneous devices. The pathophysiology of the ichthyoses. Most of these studies focus on in vitro models of epidermis.

Clinical Research Interests

General dermatology with special interest in individuals with inherited disorders of keratinization, with nail disorders, and with blistering skin disorders. Dr. Fleckman is the Principal Investigator of the National Registry for Ichthyosis and Related Disorders, an NIH-sponsored research registry for individuals with disorders of keratinization, and is the editor emeritus of the Dermatology Online Journal.

Representative Publications

Chan A, Godoy-Gijon E, Nuno-Gonzalez A, Crumrine D, Hupe M, Choi E-H, Gruber R, Williams ML, Fleckman P, Elias PM: Cellular basis for secondary infections and impaired desquamation in certain inherited ichthyoses. In press 2014 JAMA Dermatology

Kazem S, van der Meijden E, Wang RC, Rosenberg AS, Pope E, Benoit T, Fleckman P, Feltkamp MCW. Polyomavirus-associated trichodysplasia spinulosa involves hyperproliferation, pRB phosphorylation and upregulation of p16 and p21. PLOS One, 2014, Oct 7;9(10):e108947. doi: 10.1371/journal.pone.0108947. eCollection 2014. PubMed PMID: 25291363.

Usui ML, Underwood RA, Fleckman P, Olerud JE. Parakeratotic Corneocytes Play a Unique Role in Human Skin Wound Healing. J Invest Dermatol 13:856-858, 2013 [2012 Sep 27 Epub ahead of print]. PMID 23014344, PMC3532577.

Fleckman P, Jaeger K, Silva K, Sundberg JP. Comparative Anatomy of Mouse and Human Nail Units. Anat Rec (Hoboken) 296(3):521-32, 2013. PMID 23408541, PMC3579226.

Zhao G, Usui ML, Lippman SI, James GA, Stewart PS, Fleckman P, Olerud JE: Biofilms and Chronic Wounds. Adv Wound Care 2:389-399, 2013. PMID 24527355, PMC3763221.

Fleckman P, Newell BD, van Steensel MA, Yan AC: Topical Treatment of the Ichthyoses. Dermatol Ther, Jan;26(1):16-25, 2013. PMID 23384017.

Di Chiacchio N, de Farias CD, Piraccini:BM, Hirata SH, Richert B, Zaiac M, Daniel R, Fanti PA, Andre J, Ruben BS, Fleckman P, Rich P, Haneke E, Chang P, Cherit JD, Scher R, Tosti A: Consenso sobre dermatoscopia da placa ungueal em melanoniquias (Consensus on melanonychia nail plate dermoscopy). An Bras Dermatol 88:309-313, 2013. PMID 23739699.

Secor PR, Jennings LK, James GA, Kirker KR, Pulcini ED, McInnerney K, Gerlach R, Livinghouse T, Hilmer JK, Bothner B, Fleckman P, Olerud JE, Stewart PS. Phevalin (aureusimine B)production by Staphylococcus aureus biofilm and impacts on human keratinocyte gene expression. PLoS One. 2012;7(7):e40973. Epub 2012 Jul 13. PMID 22808288, PMC3396627.

Fleckman P, DiGiovanna JD: The ichthyoses. IN Fitzpatrick’s Dermatology in General Medicine. Goldsmith LA, Katz SI, Gilchrest B, Paller AS, Leffell DJ, Wolff K eds, 8th edn. McGraw Hill, New York, 507-538, 2012.

Sundberg JP, Nanney LB, Fleckman P, King LE: Skin and adnexa. IN Comparative anatomy and histology. A mouse and human atlas. Treuting PM, Dintzis SM, eds. Elsevier, Amsterdam, 2012.

Fuchs-Telem D, Sarig O, van Steensel MAM, Isakov O, Israeli S, Nousbeck J, Winnepenninckx V, Shomron N, Uitto J, Fleckman P, Richard G, Eli Sprecher E: Familial pityriasis rubra pilaris is caused by mutations in CARD14. Am J Hum Genet 91:163-170, 2012. PMID 22703878, PMC3397268.

Zhao G, Usui ML, Underwood RA, Singh PK, James GA, Stewart PS, Fleckman P, Olerud JE: Time Course Study of Delayed Wound Healing in a Biofilm-Challenged Diabetic Mouse Model. Wound Repair Regen 20:342-352, 2012. PMID 22564229, PMC3349451.

Kazem S, van der Meijden E, Kooijman S, Rosenberg A, Hughey L, Browning JC, Sadler G, Busam K, Pope E, Benoit MT, Fleckman P, de Vries E, Eekhof J, Feltkamp M: Trichodysplasia spinulosa in immunocompromized patients is characterized by active polyomavirus infection. J Clin Virol 53:225-230, 2012. PMID 22196870.

Fleckman P, Usui M, Zhao G, Underwood R, Maginness M, Marshall A, Glaister C, Ratner B, Olerud J: Cutaneous and inflammatory response to long-term percutaneous implants of porous/solid poly(HEMA) and silicone in mice. J Biomed Mater Res A 100:1256-1268, 2012. PMID 22359383, PMC3506026.

For a complete listing of all publications, please email drmadmin@uw.edu

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