paul nghiem, md, phd
Head, Division of Dermatology
Professor, Division of Dermatology
Adjunct Professor, Department of Pathology & Department of Oral Health Sciences
George F. Odland Endowed Chair in Dermatology
Patient care-related matters:
UW Medical Center
at South Lake Union
850 Republican Street
Seattle, WA 98195-8050
Education and Training
M.D. Stanford University School of Medicine, Stanford, CA, 1994
Ph.D. Stanford University, Program in Cancer Biology Stanford, CA, 1994
A.B. Biological Sciences, Harvard University, Boston, MA, 1986
A central research interest is focused on skin cancer biology, particularly the molecular mechanism by which the protein kinase ATR mediates an essential cell cycle arrest following DNA damage such as by ultraviolet radiation. It appears that the skin cancer preventive effect of caffeine is mediated by its inhibition on the ATR-Chk1 pathway, hence eliminating UV-damaged cells from the skin.
A major portion of the lab is focused on basic, clinical and translational research aspects of Merkel cell carcinoma. We are involved in several clinical studies on this increasingly common and often lethal skin cancer to determine its basic genetic underpinnings as well as its clinical course and optimal management. The Merkel cell carcinoma Multicenter Interest Group (MMIG; http://www.merkelcell.org/MMIG.html), an international collaborative group, has been formed to leverage diverse resources, interests and expertise to make a difference in this cancer.
View Nghiem Lab Website
View Basic Research Publications
Merkel cell carcinoma, melanoma, graft vs. host disease of the skin.
View Merkel Cell Carcinoma website.
View Clinical Publications