 Professor, Division of Dermatology
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CONTACT INFORMATION Philip Fleckman, M.D. |
EDUCATION AND TRAINING M.D., Washington University School of Medicine, 1973 Internship in Medicine at Barnes Hospital, 1973-74 Postdoctoral fellowship in the USPHS, NIMH, NIH, Bethesda, MD, Residency in Dermatology, Yale University School of Medicine, 1978-80 RESEARCH AND CLINICAL INTERESTS Research: Developmental biology of the distal digit. Healing skin around percutaneous devices. The pathophysiology of the ichthyoses. Most of these studies focus on in vitro models of epidermis. Clinical: General dermatology with special interest in individuals with inherited disorders of keratinization, with nail disorders, and with blistering skin disorders. Dr. Fleckman is the Principal Investigator of the National Registry for Ichthyosis and Related Disorders, an NIH-sponsored research registry for individuals with disorders of keratinization, and is the editor emeritus of the Dermatology Online Journal. REPRESENTATIVE PUBLICATIONS Fallon PG, Sasaki T, Sandilands A, Campbell LE, Saunders SP, Mangan NE, Callanan JJ, Kawasaki H, Shiohama A, Kubo A, Sundberg JP, Presland RB, Fleckman P, Shimizu N, Kudoh J, Irvine AD, Amagai M, McLean WHI: A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming. Nat Genet, 2009. Eprint ahead of publication 6 April. Fleckman P, Olerud JE: Models for the histologic study of the skin interface with percutaneous biomaterials. Biomed Mater 034006, 2008. PMID: 18708704. Farasat S, Wei MH, Liewehr DJ, Steinberg SM, Bale SJ, Fleckman P, Toro JR: Transglutaminase-1 and genotype-phenotype investigations of 104 patients with autosomal recessive congenital ichthyosis the United States. J Med Genet 46:103-111, 2008. PMID 18948357. Fleckman P, DiGiovanna JD: The ichthyoses. IN Fitzpatrick’s Dermatology in General Medicine. Wolff K, Goldsmith LA, Katz SI, Gilchrest B, Paller AS, Leffell DJ, eds, 7th edn. McGraw Hill, New York, 401-424, 2008. Isenhath SN, Fukano Y, Usui ML, Underwood RA, Irvin CA, Marshall AJ, Hauch KD, Ratner BD, Fleckman P, Olerud JE: A mouse model to evaluate the interface between skin and a percutaneous device. In press, J Biomed Mater Res A 83A:915-922, 2007. PMID 17567856. Smith FJD, Irvine AD, Terron-Kwiatkowski A, Sandilands A, Campbell LE, Zhao Y, Liao H, Evans AT, Goudie DR, Lewis-Jones S, Arseculeratne G, Munro CS, Sergeant A, O’Regan G, Bale SJ, Compton JG, DiGiovanna JJ, Presland RB, Fleckman P, McLean WHI: Loss-of-function mutations in the filaggrin gene cause ichthyosis vulgaris. Nat Genet 38:337-342, 2006. PMID 16444271. Fukano Y, Knowles NG, Usui ML, Underwood RA, Hauch KD, Marshall AJ, Ratner BD, Giachelli C, Carter WG, Fleckman P, Olerud JE: Characterization of an in vitro model for evaluating the interface between skin and percutaneous biomaterials. Wound Repair Regen 14:484-491, 2006. PMID 16939578. Allan CH, Fleckman P, Fernandes RJ, Hager B, James J, Wisecarver Z, Satterstrom FK, Gutierrez A, Norman A, Pirrone A, Underwood RA, Rubin BP, Zhang M, Ramay HR, Clark JM. Tissue response and Msx1 expression after human fetal digit tip amputation in vitro. Wound Repair Regen 14:398-404, 2006. PMID 16939566. ADDITIONAL REPRESENTATIVE PUBLICATIONS Dermatology Home | Dermatology Table of Contents | DOM Home | UW Home
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