Joseph Beavo

Professor

UW Health Sciences Center

Pharmacology

Email: beavo@uw.edu

Research Interest: Central Regulation of Body Weight and Glucose Metabolism, Complications of Diabetes

DRC Publications

Golkowski, M; Shimizu-Albergine, M; Suh, HW; Beavo, JA; Ong, SE ; Studying mechanisms of cAMP and cyclic nucleotide phosphodiesterase signaling in Leydig cell function with phosphoproteomics Cell Signal 28 7: 764-78; 2016

Egbert, JR; Uliasz, TF; Shuhaibar, LC; Geerts, A; Wunder, F; Kleiman, RJ; Humphrey, JM; Lampe, PD; Artemyev, NO; ... Jaffe, LA Luteinizing Hormone Causes Phosphorylation and Activation of the cGMP Phosphodiesterase PDE5 in Rat Ovarian Follicles, Contributing, Together with PDE1 Activity, to the Resumption of Meiosis Biol Reprod 94 5: 110; 2016 PMC4939740

Lukowski, R; Krieg, T; Rybalkin, SD; Beavo, J; Hofmann, F ; Turning on cGMP-dependent pathways to treat cardiac dysfunctions: boom, bust, and beyond Trends Pharmacol Sci 35 8: 404-13; 2014

Patrucco, E; Domes, K; Sbroggio, M; Blaich, A; Schlossmann, J; Desch, M; Rybalkin, SD; Beavo, JA; Lukowski, R; ... Hofmann, F Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis Proc Natl Acad Sci U S A 111 35: 12925-9; 2014 PMC4156763

Kraynik, SM; Miyaoka, RS; Beavo, JA ; PDE3 and PDE4 isozyme-selective inhibitors are both required for synergistic activation of brown adipose tissue Mol Pharmacol 83 6: 1155-65; 2013 PMC3657100

Rybalkin, SD; Hinds, TR; Beavo, JA ; Enzyme assays for cGMP hydrolyzing phosphodiesterases Methods Mol Biol 1020 51-62; 2013 PMC4091765

Tsai, LC; Beavo, JA ; Regulation of adrenal steroidogenesis by the high-affinity phosphodiesterase 8 family Horm Metab Res 44 10: 790-4; 2012 PMC4020523

Tsai, LC; Chan, GC; Nangle, SN; Shimizu-Albergine, M; Jones, GL; Storm, DR; Beavo, JA; Zweifel, LS ; Inactivation of Pde8b enhances memory, motor performance, and protects against age-induced motor coordination decay Genes Brain Behav 11 7: 837-47; 2012 PMC3467314