Lipoprotein Physiology and Atherosclerosis
An important focus for a number of DERC Affiliates at the University of Washington has been the relationship between diabetes, lipoproteins, and atherosclerosis. As is evident from this list, many investigators at the University of Washington have a longstanding history of high-quality productivity in clinical, basic, and translational research related to the role of diabetes in dyslipidemias and atherosclerosis. The list also includes new investigators that bring innovative and cutting-edge approaches to this area of research. These investigators commonly collaborate on individual grants-sponsored research programs and formally work together on several program project grants dealing with specific aspects of lipoprotein metabolism and atherosclerosis.
| Principal Investigator |
DERC Project |
| Bardia Askari, Ph.D. |
The Role of Aldosterone in Macrophage Function in Diabetes Accelerated Atherosclerosis (P&F) |
| Melissa Austin, Ph.D. | Genetics of the Metabolic Syndrome in Japanese Americans |
| Karin Bornfeldt, Ph.D. | Cellular Signaling in Diabetes-Accelerated Atherosclerosis |
| John Brunzell, M.D. | Central Obesity Syndrome in a Subset of Type 1 Diabetes |
| Darcy Carr, M.D. | Insulin Sensitivity, Hemodynamics, & Endothelial Function in Women with a History of Preeclampsia |
| Alan Chait, M.D. | Lipoprotein Matrix Interactions in Diabetes
Serum Amyloid A (SAA) and Diabetes |
| Mary Chang, Ph.D. |
Regulation of Proteoglycans and Hyaluronan Synthesis in Human Monocyte-Derived Macrophages by Factors Associated with Diabetes (P&F) |
| Samir Deeb, Ph.D. | The Genetics and Regulation of Hepatic Lipase |
| Jay Heinecke, M.D. | Mechanisms of Oxidative Stress in Diabetes |
| Gail Jarvik, Ph.D. | Family Studies of Lipoproteins and Coronary Disease
|
| Francis Kim, M.D. |
Glucose-Mediated Generation of Superoxide in Endothelial Cells
|
| Robert Knopp, M.D. | Diets for Dyslipidemia in the Metabolic Syndrome
Effects of Insulin, Resistance on the Lipoprotein Response to Egg Feeding |
| Renee LeBoeuf, Ph.D. | Development of Atherosclerosis in Diabetic Mice |
| John Oram, Ph.D. | Human Arterial Cells in Diabetes: Interactions with Lipoproteins and Regulation of Cell Cholesterol Metabolism |
| Tomas Vaisar, Ph.D. | Macrophage Derived Matrix Metalloproteinases in Diabetes Associated Atherosclerosis (P&F) |
| Tom Wight, Ph.D. | Amylin-Proteoglycan (Perlecan) Interaction in Diabetes |
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