Etiology and Pathogenesis of Type 1 Diabetes
The University of Washington and its affiliated institutions have a strong history in research growth, scientific excellence and productivity in the etiology and pathogenesis of type 1 diabetes. The type 1 diabetes research base includes epidemiological studies, genetic etiology, cellular and humoral aspects of the pathogenesis including prediction and prevention studies as well as novel treatment approaches including islet transplantation. Basic studies are conducted in spontaneously diabetic animals including the NOD mouse, HLA-humanized mice and the BB rat. The investigators in this area of the DERC research base contribute to Clinical Trials in Type 1 diabetes (see Affiliate listing for the Clinical Trials and Epidemiologic Studies research base). A total of 20 Affiliate Investigators are funded for etiology and pathogenesis of type 1 diabetes research and the DERC Cores are essential to the success of their research.
| Principal Investigator |
DERC Project |
| James Callis, Ph.D. | Non-Invasive Assessment & Purification of Human Islets |
| Steven Chessler, M.D., Ph.D. | Islet Autoantigen Detection |
| Patrick Concannon, Ph.D. |
Genome-Wide Searches for Type 1 Diabetes Susceptibility Genes
|
| Ruth Ettinger, Ph.D. | MHC in Spontaneous Type 1 Diabetes |
| Lakshmi Gaur, Ph.D. | Induction of Tolerance to Islet Allografts in Primates |
| Carla Greenbaum, M.D. | Juvenile Diabetes Research Foundation International Center for Translational Research Clinical Core |
| William Hagopian, M.D., Ph.D. | Prediction, Pathogenesis & Prevention of T1D in the General Population |
| Christiane Hampe, Ph.D. | Epitope-Specific GAD65 Monoclonal Antibodies Modulate GAD65 Antigen Processing & Presentation |
| David Hockenberry, M.D. | Bxl-XL Function |
| Ake Lernmark, Ph.D. | Type 1 Diabetes Immunogenetics
Genetic Dissection of BB Rat Diabetes |
| Santica Marcovina, Ph.D. |
Northwest Lipid Metabolism & Diabetes Research Laboratory
|
| Gerald T Nepom, M.D., Ph.D. | Autoantigen-Specific T Cells in T1DM |
| William Osborne, Ph.D. | Gene Therapy for Diabetes |
| Richard Palmiter, Ph.D. | Hormonal Responses to Hypoglycemia by Mice Lacking Ability to Make Norepinephrine |
| Jerry Palmer, M.D. | Pathogenesis & Prevention of T1DM |
| Catherine Pihoker, M.D. | SEARCH for Diabetes in Youth of the Puget Sound |
| Joanna Reems, Ph.D. | Culturing Human Pancreatic Islets & Assessing Their Functionality |
| Paul Robertson, M.D. | Pancreas & Islet Transplantation in Humans |
| Ian Sweet, Ph.D. | Role of Hypoxia in Death of Isolated Islets |
| Jay Taborsky, Ph.D. | Neural Regulation of Islet |
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