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Etiology and Pathogenesis of Type 1 Diabetes

The University of Washington and its affiliated institutions have a strong history in research growth, scientific excellence and productivity in the etiology and pathogenesis of type 1 diabetes. The type 1 diabetes research base includes epidemiological studies, genetic etiology, cellular and humoral aspects of the pathogenesis including prediction and prevention studies as well as novel treatment approaches including islet transplantation. Basic studies are conducted in spontaneously diabetic animals including the NOD mouse, HLA-humanized mice and the BB rat. The investigators in this area of the DERC research base contribute to Clinical Trials in Type 1 Diabetes (see Affiliate listing for the Clinical Trials and Epidemiologic Studies research base). A total of 20 Affiliate Investigators are funded for etiology and pathogenesis of type 1 diabetes research and the DERC Cores are essential to the success of their research.

Principal Investigator DERC Project
Lydia Aguilar-Bryan, M.D., Ph.D. Molecular Basis for Hyperinsulinemic Hypoglycemia and Neonatal Diabetes in Newborns and Infants
Andrey Babenko, M.D., Ph.D. Studies of Mutant SUR1/Kir6.2 Channels Causing Human Neonatal Diabetes Mellitus
Steven Chessler, M.D., Ph.D.Islet Autoantigen Detection
Ruth Ettinger, Ph.D.MHC in Spontaneous Type 1 Diabetes
Lakshmi Gaur, Ph.D.Induction of Tolerance to Islet Allografts in Primates
Carla Greenbaum, M.D.Juvenile Diabetes Research Foundation International Center for Translational Research Clinical Core
William Hagopian, M.D., Ph.D.Prediction, Pathogenesis & Prevention of T1D in the General Population
Michael Haller, M.D. Autologous Cord Blood Transfusion to Reverse Hyperglycemia in Children with Type 1 Diabetes -- A Pilot Study
Christiane Hampe, Ph.D.Epitope-Specific GAD65 Monoclonal Antibodies Modulate GAD65 Antigen Processing & Presentation
David Hockenberry, M.D.Bxl-XL Function
Bertil Hille, Ph.D. Paracrine Effect of Fast Neurotransmitters on Insulin Secretion
Lucas Hoffman, M.D., Ph.D. Mechanisms of Bacterial Antibiotic Resistance and Pathogenesis in Cystic Fibrosis
Fouad Kandeel, M.D., Ph.D. Assessment of Human Islet Quality
Warren Ladiges, D.V.M., M.S. Effects of Mitochondrial Catalase Expression in Protection of Islets
Ake Lernmark, Ph.D.Type 1 Diabetes Immunogenetics

Genetic Dissection of BB Rat Diabetes
Santica Marcovina, Ph.D. Northwest Lipid Metabolism & Diabetes Research Laboratory
Gerald T Nepom, M.D., Ph.D.Autoantigen-Specific T Cells in T1DM
Toan Nguyen, M.D. Human Pancreatic Duct Cells: Culture and Characterization
William Osborne, Ph.D.Gene Therapy for Diabetes
Richard Palmiter, Ph.D.Hormonal Responses to Hypoglycemia by Mice Lacking Ability to Make Norepinephrine
Jerry Palmer, M.D.Pathogenesis & Prevention of T1DM
Catherine Pihoker, M.D.SEARCH for Diabetes in Youth of the Puget Sound
Joanna Reems, Ph.D.Culturing Human Pancreatic Islets & Assessing Their Functionality
Desmond Schatz, M.D. Autologous Cord Blood Transfusion to Reverse Hyperglycemia in Children with Type 1 Diabetes -- A Pilot Study
Paul Robertson, M.D.Pancreas & Islet Transplantation in Humans
Ian Sweet, Ph.D.Role of Hypoxia in Death of Isolated Islets
Jay Taborsky, Ph.D.Neural Regulation of Islet
Edith Wang, P.h.D. Regulation and Function of TAF1 in Cellular Growth Control
Wenqing Xu, Ph.D. Crystallographic Studies of Protein Kinase B

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