Clinical, basic, and translational research on the pathophysiology of type 2 diabetes has long been a major focus of investigators among many departments at the University of Washington. The quality of the research being performed in this area of the DERC Research Base continues to be outstanding and also reflects the entry of a number of new young investigators into this area. Close collaboration between members of the faculty at the University of Washington as well as with faculty at other institutions is an additional strength of the work in this area.
| Principal Investigator |
DERC Project |
| Salwa Al-Noori, Ph.D. |
Dentate Gyrus Modulation of the Counter Regulatory Response to Recurrent Hypoglycemia |
| Melissa Austin, Ph.D. |
Genetics of the Metabolic Syndrome in Japanese Americans |
| Mark Bothwell, Ph.D. |
LIG Protein Regulators of Growth Factor Signaling in Pancreatic Beta Cells |
| Daniel Bowen-Pope, Ph.D. |
Regulation of Insulin Secretion by Phogrin and IA-2 |
| Joseph Bryan, Ph.D. |
Does Intraislet ZN2+, Co-secreted with Insulin, Suppress Glucagon Release Via Activation of KATP? |
| Darcy Carr, M.D. |
Insulin Sensitivity, Hemodynamics, & Endothelial Function in Women with a History of Preeclampsia |
| Ian deBoer, M.D. |
Pilot Clinical Trial of Vitamin D3 Therapy in the Metabolic Syndrome |
| David Cook, Ph.D. |
The Role of the Liver and Insulin Resistance in Regulating Peripheral A-beta Clearance |
| Kevin Conley, Ph.D. |
Muscle Metabolism and Energetics in Type 2 Diabetes |
| Suzanne Craft, Ph.D. |
Insulin Resistance & CNS Function in T2DM
Insulin, Neurogenetics & Memory in Alzheimer's Disease: A Novel Therapeutic Approach
The Effects of Rosiglitazone in Patients with Mild Cognitive Impairment
Therapeutic Effects of Intranasal Insulin in Alzheimer's Disease
Glucose Regulation and Memory in Alzheimer's Disease |
| David D'Alessio, M.D. |
The Role of GLP-1 on Normal and Abnormal Glucose Tolerance |
| Glen Duncan, Ph.D. |
Kinetics of Human Homocysteine Metabolism |
| Pattie S. Green, Ph.D. |
Modulation of Plasma Beta-Amyloid by Insulin |
| Bertil Hille, Ph.D. |
Paracrine Effect of Fast Neurotransmitters on Insulin Secretion |
| Rebecca Hull, Ph.D. |
Islet Amyloid Induces Islet -Cell Death Through Increased Endoplasmic Reticulum Stress (P&F)
Role of Matrix Metalloproteinases in Islet Amyloid Formation
Role of Perlecan in Islet Amyloid Formation |
| Steven Kahn, M.B., Ch.B |
Proinsulin & Islet Amyloid Polypeptide in States of Normal and Abnormal Islet Function |
| Fouad Kandeel, M.D., Ph.D. |
Assessment of Human Islet Quality |
| Robert Knopp, M.D. |
Diets for Dyslipidemia in the Metabolic Syndrome
Effects of Insulin, Resistance on the Lipoprotein Response to Egg Feeding |
| Mario Kratz, Ph.D. |
Cytokines and Type 2 Diabetes |
| Martin Kushmerick, Ph.D. |
Mitochondrial Redox Quantification in Fast and Slow Twitch Murine Muscle |
| Marguerite McNeely, M.D. |
Skeletal Muscle Fat and Risk of Type 2 Diabetes in Japanese Americans |
| Toan Nguyen, M.D. |
Human Pancreatic Duct Cells: Culture and Characterization |
| LeBris Quinn, Ph.D. |
IL-15, Body Composition and Insulin Sensitivity in Aging |
| Paul Robertson, M.D. |
Glucose Regulation of Pancreatic Islet Gene Expression |
| Leslie Satin, Ph.D. |
Oscillatory Mechanisms of Pancreatic Islets |
| Ian Sweet, Ph.D. |
Role of Hypoxia in Death of Isolated Islets
Bioenergetics of Glucose-Induced Insulin Secretion in Pancreatic Islets |
| Robert Steiner, Ph.D. |
Brain Genes Governing Reproduction
|
| Elaine Tsai, M.D., M.P.H. |
Identifying Risk Factors for Impaired Glucose Tolerance & Diabetes in Veterans with Central Obesity |
| Kristina Utzschneider, M.D. |
Insulin Resistance in Non-Alcoholic Steatohepatitis |
| Peter Vitaliano, Ph.D. |
Chronic Stress, Physiological Mediators and Coronary Disease |
| Wenqing Xu, Ph.D. |
Crystallographic Studies of Protein Kinase B |