Studies of energy homeostasis and obesity are a longstanding strength at the University of Washington. Research in this arena is conducted by Affiliates in numerous departments and the caliber of science is outstanding. There is extensive cooperation and collaboration among body-weight researchers across departments at UW, with other institutions, and spanning diverse fields of study. The Obesity Research Base is particularly successful at training young independent investigators in the field, as well as recruiting established scientists from other disciplines into metabolic research. These investigators make heavy use of DERC Biomedical Research Cores for technical help and services.
| Principal Investigator |
DERC Project |
| Melissa Austin, Ph.D. |
Genetics of the Metabolic Syndrome in Japanese Americans |
| Denis Baskin, Ph.D. |
Insulin and Leptin Action in the Brain |
| Joseph Beavo, Ph.D. |
In Vivo Studies of Insulin and Leptin Signaling through Phosphodiesterase 3B Studies on the Roles of Specific Cyclic Nucleotide Phosphodiesterases in Immune Cell Function |
| James Blevins, Ph.D. |
Leptin-Regulated Brain Pathways in Feeding and Obesity |
| Edward Boyko, M.D. |
Japanese American Community Diabetes Study |
| John Brunzell, M.D. |
Central Obesity Syndrome in a Subset of T1DM |
| David Cummings, M.D. |
Meal Initiation and Energy Homeostasis: Role of Ghrelin |
| Ian deBoer, M.D. |
Pilot Clinical Trial of Vitamin D3 Therapy in the Metabolic Syndrome |
| Samir Deeb, Ph.D. |
Genetic Variation Associated with Lipemic Response to Diet, Insulin Resistance and Obesity |
Dianne
Figlewicz-Lattemann, Ph.D. |
Regulation of Brain Catecholamines by Insulin in Normal, Diabetic, and Obese Rats |
| Annette Fitzpatrick, Ph.D. |
A Twin Study of Inflammation and Obesity: Genetic and Environmental Influences (NIA) |
| David Flum, M.D. |
Understanding Mechanisms of Weight Loss in Bariatric Surgery - Development of an Animal Model |
| Peter Havel, D.V.M., Ph.D. |
Islet Morphology and Function in Rat Models of Obesity and Insulin Resistance |
| Steven Kahn, M.B., Ch.B |
Type 2 Diabetes Primary Prevention Trial
Look Ahead - A Study of the Effect of Weight Loss on Health Outcomes in Subjects with T2DM |
| Robert Knopp, M.D. |
Effects of Low-Fat, High Carbohydrate Diet in Men and Women |
| Albert La Spada, M.D., Ph.D. |
Role of PGC-1-alpha in Huntington's Disease Metabolic Abnormalities and Neurodegeneration |
| Santica Marcovina, Ph.D. |
Diabetes Prevention Outcome Study (DPPOS) formerly Diabetes Prevention Program Central Biochemistry Laboratory |
| Stan McKnight, Ph.D. |
Role of Protein Kinase A in Obesity and Diabetes |
| Marguerite McNeely, M.D. |
Predictors and Correlates of Visceral Adiposity |
| Gregory Morton, Ph.D. |
Effect of Hypothalamic Leptin Action on Glucose Metabolism (P&F) |
| LeBris Quinn, M.D. |
Direct Effects of Interleukin-15 on Adipocytes |
| Michael Schwartz, M.D. |
Hormonal Regulation of Hypothalamic Neuropeptide Y in the Control of Energy Balance |
| Daniel Storm, Ph.D. |
Type 3 Adenylyl Cyclase Mutant Mice as a Model for Obesity |
| Robert Steiner, Ph.D. |
Brain Genes Governing Reproduction
|
| Elaine Tsai, M.D., MPH |
Identifying Risk Factors for Impaired Glucose Tolerance & Diabetes in Veterans with Central Obesity |
| Scott Weigle, M.D. |
An Insulin Secretagogue from Adipose Tissue
Role of Leptin in the Pathophysiology of Human Obesity
Effect of Diet Composition on Body Weight Regulation
Metabolic Consequences of Aggressive Antiretroviral Therapy
Increased Omega-3 Fatty Acid Intake in the Treatment of Obesity |
| Brent Wisse, M.D. |
Melanocortins, Energy Balance and Cancer Anorexia The Role NF-KB Signaling in Central Leptin Resistance |