Diabetes News You Can Use Archive

Study examines severe hypoglycemia with intensive treatment for type 1 diabetes

Researchers analyzed data from the Diabetes Control and Complications Trial and Epidemiology of Diabetes Interventions and Complications study that ran between 1983 and 1993 and found that type 1 diabetes patients in the intensive treatment group had three times as many severe hypoglycemic episodes as those in the non-intensive group. The findings in Diabetes Care revealed that… Read more »

Few US adults meet most nutrition, activity goals for diabetes risk reduction

A study in Diabetes Care showed that only 3.1% of US adults met the majority of lifestyle behaviors tied to type 2 diabetes risk reduction, with a lower probability of meeting such goals observed among those who were younger and had lower educational attainment. Researchers analyzed 3,679 non-pregnant, non-lactating individuals without diabetes, ages 20 or… Read more »

Research highlights importance of addressing hypoglycemia in diabetes care

Researchers evaluated more than 750 scientific articles and found that health care professionals in the US lack clinical resources to help them identify older type 2 diabetes patients at risk of hypoglycemia. The findings in The Journal of Clinical Endocrinology & Metabolism suggested that health care professionals should work from the same quality initiatives, such… Read more »

Research examines costs associated with diabetes in US in 2017

A study in Diabetes Care showed that last year’s total estimated cost of diagnosed diabetes in the US was $327 billion, including $90 billion in reduced productivity and $237 billion in direct medical costs. Researchers also found that patients with diabetes had average medical expenditures of about $16,750 annually, with approximately $9,600 of the expenses… Read more »

Study: Clinical trial participants say sharing health data is beneficial

Eighty-one percent and more than 85% of 771 surveyed clinical trial participants reported that data sharing would benefit physicians and scientists, respectively, according to a study in The New England Journal of Medicine. Less than 10% of respondents reported being “very” concerned about the possible consequences of data sharing, while less than a third expressed… Read more »

Global increase in diabetes means higher demand for insulin

A study in The Lancet Diabetes & Endocrinology found that a global diabetes epidemic is expected to increase demand for insulin by more than 20% by 2030, but insulin will not be available for half of the estimated 79 million people with type 2 diabetes. Global insulin use of the 1,000-unit vials is projected to… Read more »

Study: Improved outcomes seen with insulin pump therapy use in adolescents

Adolescent type 2 diabetes patients who used an insulin pump therapy for three months reduced their A1C levels by 1.3% and their average blood glucose from 205±91 mg/dL to 161±70 mg/dL, according to a study presented at ENDO 2017: the 99th Annual Meeting & Expo. Researchers evaluated five female patients with poor glycemic control and… Read more »

CMS to add diabetes prevention program as covered Medicare benefit

  Beginning April 1, the expanded model of the Medicare Diabetes Prevention Program will be added as a covered benefit for beneficiaries who are enrolled in Part B and have A1C levels between 5.7% and 6.4%, body mass index of at least 25, a two-hour plasma glucose of 140 to 199 mg/dL or fasting plasma glucose of… Read more »

Study: Newer oral glucose-lowering drugs have risk reduction benefits

A study in Diabetes, Obesity & Metabolism showed that type 2 diabetes patients treated with SGLT2 inhibitor dapagliflozin had a 56% lower risk for all-cause mortality and a 49% reduced risk for fatal and nonfatal cardiovascular disease, compared with those on insulin. Swedish researchers evaluated more than 20,000 adults with type 2 diabetes and found… Read more »

Study finds 2-hour postload glucose effective in predicting CV events in CAD

Researchers found that two-hour postload glucose was a better predictor of cardiovascular events among patients with coronary artery disease but without previously known diabetes than A1C or fasting plasma glucose. The findings in Diabetes Care, based on 3,775 patients, revealed that an A1C between 5.7% and 6.5% and 2h-PG between 7.8 and 11.0 mmol/L were independent… Read more »

Study: Plasma glucose challenge testing is most accurate for diabetes

A study in Diabetic Medicine showed that plasma glucose challenge testing provided more accurate results for diabetes and high-risk dysglycemia detection and was cheaper, compared with A1C, random capillary glucose and random plasma glucose testing methods. Researchers analyzed data from 1,535 patients in a Veterans Health Administration primary care clinic and also found that capillary… Read more »

Neovacs to begin preclinical trial of antibody vaccine for type 1 diabetes

Neovacs’ interferon-alpha kinoid vaccine for type 1 diabetes will enter a preclinical trial under a collaboration agreement with researchers at the Cochin Hospital in Paris. The vaccine, which was studied as a lupus treatment in phase 1 and 2 trials, produces polyclonal neutralizing antibodies to interrupt IFN-alpha. Healio (free registration)/Endocrine Today (10/22) News provided by… Read more »

Study: Complications more common in youths with type 2 versus type 1 diabetes

Adolescents and young adults with type 2 diabetes were more likely to have diabetic kidney disease, arterial stiffness, hypertension, peripheral neuropathy and retinopathy, compared with type 1 diabetes patients, according to a study in the Journal of the American Medical Association. Researchers used a cohort of 2,018 type 1 and type 2 diabetes patients and… Read more »

Researchers ID 111 additional loci tied to type 2 diabetes

Researchers have identified 111 new chromosome locations related to the development of type 2 diabetes, according to a study in The American Journal of Human Genetics. UK researchers noted that 93 of the 111 loci are found in African American and European populations, while 18 loci were specific to Europeans. United Press International (5/8) News… Read more »

Researchers examine prevalence of DPN among youths with diabetes

Researchers examine prevalence of DPN among youths with diabetes Seven percent of young type 1 diabetes patients and 22% of young type 2 diabetes patients had diabetic peripheral neuropathy, and the risk of DPN was associated with glycemic control in patients with type 1 diabetes, but not among those with type 2 diabetes, according to… Read more »

Research shows benefits of continuous glucose monitoring in diabetes

A study in the Annals of Internal Medicine showed that type 2 diabetes patients treated with multiple daily insulin injections reduced their mean A1C levels from 8.5% at baseline to 7.5% 12 weeks after using continuous glucose monitoring, compared with dropping to 7.9% among those in the blood glucose meter testing only group. Researchers used… Read more »

Research shows decline in rates of CVD hospitalization in diabetes

Research shows decline in rates of CVD hospitalization in diabetes A study in Diabetes Care showed significant declines in age-adjusted hospitalization rates for acute coronary syndrome, ischemic stroke, cardiac dysrhythmia, hemorrhagic stroke and heart failure among individuals with diabetes from 1998 to 2014. Researchers analyzed data from the National Inpatient Sample involving adults ages 35 and older… Read more »

Research shows positive effects of GLP-1 RA on heart health in diabetes

Type 2 diabetes patients who received GLP-1 receptor agonists experienced a 10% reduction in their risk for a combination of stroke, heart attack or death from heart disease, a 13% reduction in heart disease mortality risk and a 12% reduced risk for all-cause mortality, compared with those on placebo, according to a study in The Lancet… Read more »

Metabolic surgery can help prevent microvascular complications in diabetes

Patients with type 2 diabetes patients and obesity who underwent metabolic surgery had a significantly lower incidence of microvascular complications, compared with those who received usual medical treatment, according to a study in the British Journal of Surgery. German researchers conducted a literature review of 10 studies involving 17,532 patients and found surgery also improved pre-existing… Read more »

Study compares effect of diet on gut microbiome in diabetes

Chinese researchers found that 89% of patients with type 2 diabetes who consumed high-fiber diets lost more weight, had better blood lipid profiles and showed signs that their bodies were more effectively regulating their blood glucose levels by week 12, compared with 50% of those in the standard low-fat, low-carbohydrate diet. The findings in the… Read more »

Study looks at benefits of community health worker-led intervention in diabetes

Researchers found that Latino adults with type 2 diabetes experienced greater reductions in HbA1C and diabetes distress six months after participating in a community health worker-led diabetes self-management education program, compared with those in the enhanced usual care group. The findings in Diabetes Care, based on 222 patients with diabetes and poor glycemic control, revealed that… Read more »

Research shows efficacy of dual GIP, GLP-1 RA in diabetes

A study in The Lancet showed that 15% to 82% of type 2 diabetes patients treated with LY3298176, a dual glucose-dependent insulinotropic polypeptide and GLP-1 receptor agonist, achieved the A1C target of at least 6.5% at 26 weeks, compared with 39% of those on dulaglutide or 2% on placebo. Researchers conducted a double-blind randomized Phase… Read more »

Study finds no link between canagliflozin, fracture risk in diabetes

Researchers used a cohort of 159,928 patients with type 2 diabetes, mean age of 55, and found that both canagliflozin and GLP-1 receptor agonist users had similar event rates for forearm, hip, humerus or pelvis fracture requiring intervention, with an overall hazard ratio of 0.98. The findings in the Annals of Internal Medicine revealed that… Read more »

Research finds lack of CV risk factor control in diabetes

A study in Diabetes, Obesity and Metabolism showed that only 21.6% of diabetes patients achieved composite control of all four risk factor targets for atherosclerotic cardiovascular disease — A1C, blood pressure, LDL cholesterol and not smoking — with women having a lower overall risk factor control rate at 18.6%, compared with men at 23.6%. Researchers… Read more »

Study examines changes in screening among adults without diabetes

Seventy-eight percent of 12,772 adults without diabetes, ages 45 or older, underwent diabetes screening at least once over three years, with glucose test used 86% of the time and A1C 14% of the time, according to a study in Diabetes Care. Researchers also found that A1C testing is increasingly used for screening and is associated with… Read more »

Study links diabetes to cerebral small-vessel disease

A study in Diabetes Care showed that type 1 diabetes patients were at an increased risk of having cerebral small-vessel disease and cerebral micro-bleeds, compared with those without diabetes. Finnish researchers evaluated data on 221 patients with and without diabetes and found that those with cerebral micro-bleeds were more likely to have albuminuria and higher… Read more »

Aging LGBT Americans face health disparities

“LGBT older adults face disparities in health and well-being compared to heterosexual peers, including higher rates of disability, cardiovascular disease, depression and social isolation,” said study author Karen Fredriksen-Goldsen. The findings in The Gerontologist were based on data from the 2014 national study of more than 2,400 LGBT adults, ages 50 to 100. United Press… Read more »

Study examines role of genetics in body fat distribution

Researchers analyzed data from the UK Biobank cohort involving 362,499 individuals and found 98 independent genetic factors that were related to body fat distribution, including 29 genes that were not previously associated with fat-related phenotypes. Published in Nature Communications, the study also revealed a significant difference in body fat distribution between sexes, with women more… Read more »

“Biggest Losers” keep weight off with lots of exercise

A study of 14 people who took part in “The Biggest Loser” TV show found those who were able to maintain their significant weight loss averaged 80 minutes per day of moderate exercise or 35 minutes of vigorous exercise, researchers reported in the journal Obesity and at the Obesity Society’s annual meeting. The study found the dieters… Read more »

Older men with diabetes may benefit from metformin, study finds

Researchers found that older men with type 2 diabetes who were on metformin therapy had a reduced risk of developing cancer, cardiovascular disease, dementia, depression and frailty-related diseases. The findings in the Journal of Diabetes and Its Complications, based on 41,204 men ages at least 65, also revealed an association between metformin use and a… Read more »

Diabetes is third leading cause of death in US, study finds

Diabetes accounts for 11.5% and 11.7% of deaths based on self-reported diabetes in the National Health Interview Survey and the National Health and Nutrition Examination Survey, respectively, and 11.8% based on A1C levels in NHANES, making it the third leading cause of death in the US, researchers reported in PLOS ONE. Researchers found that the… Read more »

Lower A1C levels seen in people with sickle cell trait, study finds

Journal of the American Medical Association showed that African Americans with a sickle cell trait had A1C levels of 5.72%, compared with 6.01% among those without SCT. The findings, based on 4,620 African Americans, revealed that low A1C levels were associated with significantly lower rates of prediabetes and diabetes when participants were diagnosed with A1C… Read more »

11 cancers associated with obesity, study finds

A study in The BMJ found an association between obesity and 11 cancers, including multiple myeloma, colon cancer, biliary tract system cancer, breast cancer and kidney cancer. UK researchers evaluated 95 meta-analyses and found that the increase in cancer risk for every 5-kg/m2 increase in body mass index ranged from 9% for rectal cancer in… Read more »

Insulin sensitivity in diabetes not affected by vitamin D, study finds

Norwegian researchers found no significant changes in insulin sensitivity or insulin secretion between type 2 diabetes patients who received a single dose of 400,000 IU oral vitamin D3 and those on placebo. The findings in Diabetes Care, based on 62 adults with type 2 diabetes and vitamin D deficiency, showed that vitamin D supplementation also… Read more »

Oral insulin not tied to diabetes prevention, study finds

  A study in the Journal of the American Medical Association found that giving 7.5 mg of oral insulin daily to relatives of type 1 diabetes patients did not prevent them from developing the disease, compared with those on placebo. Researchers analyzed data from 389 individuals, 57.6% of whom had a sibling with diabetes, and did find… Read more »

Reduced insulin production in diabetes tied to granule docking, study finds

A study in the journal Cell Metabolism showed that a reduction in glucose-dependent granule docking is associated with impaired insulin secretion among patients with type 2 diabetes. Researchers compared the beta cells of patients with and without diabetes and found that diabetes patients’ beta cells had a defect in the attachment of insulin vesicles to the cell… Read more »

Shift workers at increased risk of type 2 diabetes, study finds

A study in Diabetes Care showed that regardless of genetic predisposition, adults who frequently do shift work, especially at night, were at an increased risk of developing type 2 diabetes, compared with those who do not have shift work. Researchers evaluated data from the UK Biobank database involving 270,000 people and found that those who worked rotating… Read more »

More than 23M US adults are affected by diabetes, study finds

Of the more than 23 million adult patients with diabetes in the US, 21 million had type 2 diabetes, while 1.3 million had type 1 diabetes, according to a study in the CDC’s Morbidity and Mortality Weekly Report. Researchers analyzed 2016 data from the National Interview Survey involving more than 33,000 adults and found that… Read more »

MetS affects neurocognition in middle-aged adults, study finds

A study in Diabetes Care showed that adults with metabolic syndrome were more likely to satisfy low mental status criteria and had lower average global neurocognitive performance than those without MetS. Researchers evaluated cross-sectional data from 9,136 Hispanic adults, ages 45 to 74, and found that the associations between MetS and memory and learning measures were significantly… Read more »

Dual-hormone system tied to reduced hypoglycemia in diabetes, study finds

Type 1 diabetes patients who used a dual-hormone system, which includes adding glucagon delivery to a closed-loop system using wearable sensors, during moderate-intensity aerobic exercise sessions had the lowest time in hypoglycemia and lowest mean time in hypoglycemia, compared with using a single-hormone system, predictive low glucose suspend or current care, according to a study… Read more »

Insulin levels stabilize after 7 years of annual declines, study finds

A study in Diabetes Care showed that insulin levels decline by nearly 50% every year for seven years in type 1 diabetes patients, but stabilize thereafter. UK researchers evaluated 1,549 type 1 diabetes patients and said the findings indicate patients will keep any remaining working beta-cells seven years after diagnosis, which could lead to new… Read more »

Weight fluctuations tied to worse diabetes outcomes, study finds

Researchers analyzed data from the FDA Adverse Event Reporting System between April 2005 and September 2017 and found that older diabetes patients who used GLP-1 receptor agonists were not at an increased risk for diabetic retinopathy. The findings in Diabetes Care revealed that 263 of the 389 GLP-1 receptor agonist-related DR events were associated with… Read more »

New tool IDs diabetes patients at risk for hypoglycemia hospitalization

Researchers used data from electronic medical records to develop a new risk-stratification tool that was able to identify a type 2 diabetes patient’s 12-month risk of being hospitalized for hypoglycemia based on the following risk factors: age, chronic kidney disease stage, insulin use, number of prior episodes of hypoglycemia-related utilization, prior year emergency department use… Read more »

Rats grow mouse pancreases in lab

New mouse pancreases have been grown in rats using pluripotent stem cells, and the organs were then successfully transplanted into mice, reversing their diabetes, according to a study published in Nature. Researchers hope to one day grow transplantable human organs inside larger animals using the technique. LiveScience.com (1/25) News provided by DiabetesPro SmartBrief in conjunction with… Read more »

Study examines racial differences in link between mean glucose, A1C levels

Researchers found that there are racial differences in hemoglobin glycation, making A1C levels an inaccurate measurement of mean glucose concentration in black patients with type 1 diabetes. The findings in the Annals of Internal Medicine, based on 208 black and white diabetes patients ages 8 or older, revealed that blacks have a higher mean A1C… Read more »

Study ties gut microbiome changes to metabolic markers

Chinese researchers found an association between changes to the gut microbiome that correlate with more than 27 metabolic markers. The findings in Nature Medicine, based on an analysis of gut DNA sequencing data involving young Chinese adults with obesity and Chinese adults who underwent bariatric surgery, showed that some species of gut microbes in obese… Read more »

Study ties long-term metformin use to reduced CAC in men

A longitudinal cohort study in Circulation found long-term use of metformin was associated with significantly lower severity and prevalence of coronary artery calcium in men, but not women, who initiated the drug for prediabetes. The findings were based on 2,776 participants in the Diabetes Prevention Program and its DPP Outcomes Study. Medscape (free registration) (5/30) News provided by DiabetesPro… Read more »

Bariatric surgery linked to better health outcomes in obese diabetes patients

Researchers found that 29% and 23% of type 2 diabetes patients with obesity who underwent gastric bypass surgery and sleeve gastrectomy, respectively, were able to stop their diabetes medications five years after the procedure, compared with 5% of those on diabetes medications alone. The findings in the New England Journal of Medicine, based on 150… Read more »

Diabetes is most common cause of ED visits for older patients

Diabetes accounted for 25.8% of all emergency department visits made by older patients, followed by chronic pulmonary disease, renal disease, congestive heart failure and peripheral vascular disease, according to a study published in the Annals of Emergency Medicine. Researchers conducted a multicenter retrospective cohort study involving 1,259,809 patients, aged at least 65, and found frequent… Read more »

Metformin helps prevent diabetes development in at-risk patients

A study in Diabetes Care showed that adults at risk for diabetes who took 850 mg of metformin twice daily had lower diabetes incidence rates over 15 years, compared with those on placebo. Researchers used a cohort of 3,234 patients from the Diabetes Prevention Program and the Diabetes Prevention Program Outcomes Study and found that… Read more »

Research shows one-hour glucose improves diabetes prediction

The one-hour plasma glucose level during an oral glucose-tolerance test had the best performance in the early prediction of type 2 diabetes — with 75% accuracy, 75% sensitivity and 68% specificity — compared with the 30-minute and two-hour plasma glucose, A1C, clinical risk factors, metabolic markers and combinations of these variables, according to a study… Read more »

CVD risk in diabetes tied to advanced glycation end products, oxidation products

A study in Diabetes Care showed that higher levels of certain advanced glycation end products and lower levels of the oxidation product methionine sulfoxide were associated with an increased risk for cardiovascular disease among adults with type 2 diabetes. Researchers used a cohort of 716 patients with and without diabetes from the Veterans Affairs Diabetes Trial and… Read more »

USPSTF recommends referring obese adults to weight-loss programs

A US Preventive Services Task Force draft recommendation calls for primary care clinicians to refer adults with a BMI of 30 or higher to a multicomponent behavioral program for weight management. The task force said evidence shows these interventions can lead to clinically significant weight loss and reduced incidence of type 2 diabetes among obese… Read more »

Researchers help slow diabetic kidney disease progression

Australian researchers found that several mouse models with type 1 and type 2 diabetes had a reduced progression of kidney disease after being treated with the 2H10 antibody, which inhibited vascular endothelial growth factor protein signaling that reduced the accumulation of fat deposits within the kidneys. The findings in Cell Metabolism showed that the antibody… Read more »

ADA raises concerns over ACP’s diabetes management recommendations

The American College of Physicians’ recommended target A1C level of between 7% to 8% for “most” diabetes patients is “not reflective of the long-term benefits of lower A1C targets” and “could cause increased complication rates for those who may safely benefit from lower evidence-based targets,” said Dr. William Cefalu, chief scientific officer at the American… Read more »

Research examines effect of age of diabetes diagnosis on mortality risk

A study in Diabetologia showed an association between a 10-year earlier diagnosis of type 2 diabetes and a 1.2 to 1.3 times higher risk of all-cause mortality and an almost 1.6 times increased risk of cardiovascular mortality. Chinese researchers evaluated mortality data from the National Diabetes Services Scheme that was linked to the National Death Index involving… Read more »

Study IDs new genetic variants tied to lower type 2 diabetes risk

UK researchers evaluated data from the UK Biobank study involving 451,000 individuals with overweight or obesity and found 14 genetic variants, 7 of which are new, that are associated with obesity but a reduced risk of type 2 diabetes. The findings, presented at the Diabetes UK Professional Conference, revealed that the 5% of people who… Read more »

Research examines link between diabetes, heart failure risk

A study in Diabetes Care showed that adults with asymptomatic left ventricular systolic dysfunction and diabetes had higher risks for developing heart failure, HF hospitalization, composite endpoint of HF development or cardiovascular death and mortality from any cause than those without diabetes. UK researchers analyzed data from the Studies of Left Ventricular Dysfunction involving 4,223 patients and… Read more »

Study links antipsychotic drugs to gestational diabetes risk

Pregnant women who took the antipsychotics olanzapine or quetiapine were at higher risk of gestational diabetes than those who stopped treatment during pregnancy, according to a study published in The American Journal of Psychiatry and presented at the American Psychiatric Association’s annual meeting. Women who continued the drugs while pregnant had greater comorbidity and longer antipsychotic use…. Read more »

Study: Type 2 diabetes alone may not contribute to mortality risk

A study in The New England Journal of Medicine showed that patients with type 2 diabetes who did not have any risk factors — smoking, albuminuria or abnormal A1C, blood pressure or LDL cholesterol — did not have excess mortality risk or increased risk for acute myocardial infarction or stroke, but they were at a… Read more »

Research links rising fasting glucose levels to long-term CVD risk

A study in Diabetes Care showed that middle-aged adults with increasing fasting glucose levels had an increased risk for cardiovascular disease over 30 years, such as coronary heart disease and stroke, compared with individuals with normal blood glucose levels. Researchers analyzed data from seven observational cohorts and found that those who transitioned from impaired fasting… Read more »

Study links insulin resistance to circulating extracellular RNAs

Eighteen circulating extracellular RNAs were associated with insulin resistance in body mass index-, age- and sex-adjusted models across 391 ex-RNAs, according to a study in Diabetes Care. Researchers evaluated 2,317 participants without diabetes in the Framingham Heart Study Offspring Cohort and found a correlation between miR-122 and IR in children, as well as between miR-122… Read more »

Being overweight, obese increases mortality risks, study says

Research in the Annals of Internal Medicine found overall mortality risks increased by 10% for people who were overweight, 34% for those who were obese and 98% for the morbidly obese. The study, which considered patient data over 12 years, contradicts the “obesity paradox” theory that being overweight may have health or survival benefits for… Read more »

CDC reports declining sugary drink intake among US high schoolers

CDC researchers reported that the rate of ninth- to 12th-grade students who drank sugar-sweetened beverages daily dropped from more than 33% in 2007 to 20.5% in 2015, with soda consumption decreasing among boys and girls of all races and socioeconomic levels. The findings in the agency’s Morbidity and Mortality Weekly Report, based on national youth… Read more »

Adult-onset autoimmune diabetes tied to impaired whole-body insulin sensitivity

A German study in The Journal of Clinical Endocrinology & Metabolism showed that patients with recently diagnosed adult-onset autoimmune diabetes had similar insulin sensitivity rates with those with type 1 diabetes and healthy controls but significantly higher than type 2 diabetes patients, as well as beta-cell function higher than type 1 diabetes patients but lower than those… Read more »

GLP-1 RAs not tied to diabetic retinopathy risk, study shows

Researchers analyzed data from the FDA Adverse Event Reporting System between April 2005 and September 2017 and found that older diabetes patients who used GLP-1 receptor agonists were not at an increased risk for diabetic retinopathy. The findings in Diabetes Care revealed that 263 of the 389 GLP-1 receptor agonist-related DR events were associated with… Read more »

Obesity-related illnesses accounting for growing share of health spending

The proportion of medical spending attributed to obesity-related illness in adults in the US rose from 6.13% in 2001 to 7.91% in 2015 and varied from state to state, researchers reported in the journal Clinical Chemistry. Obesity-related illnesses accounted for 5% to 6% of total medical expenditures in Arizona, California, Florida and New York, and more… Read more »

Study finds reduced microvascular complications with bariatric surgery

A study in The Lancet Diabetes & Endocrinology showed that obese patients with either prediabetes or type 2 diabetes who underwent bariatric surgery had lower incident microvascular disease than patients in a usual care group. Swedish researchers used a cohort of 4,032 patients ages 37 to 60 and found the lowest hazard ratio for microvascular… Read more »

Only 29.9% of diabetes, CVD patients achieve all secondary prevention targets

Researchers analyzed data from the TECOS trial involving 13,616 adults with diabetes and cardiovascular disease from 38 countries and found that only 29.9% of patients met all five secondary prevention targets — blood pressure and lipid control, use of aspirin and prophylactic medications, and not smoking — compared with nearly three-quarters who met four of… Read more »

ADA leads effort to demand insulin pricing transparency

Several stakeholders from the diabetes community, including the American Diabetes Association, asked legislators with the Senate Special Committee on Aging for help regarding transparency with the increasing prices of insulin. The ADA’s insulin access and affordability working group released a consensus statement, published in Diabetes Care, that identified the factors influencing insulin prices and highlighted the… Read more »

Research links mutation to diabetes, insulin-producing tumors

The p.Ser64Phe mutation in the MAFA gene is likely associated with a type of non-insulin-dependent diabetes and multiple insulin-producing neuroendocrine tumors, according to a study in the Proceedings of the National Academy of Sciences. UK researchers studied the DNA of 39 adults from two families with diabetes and autosomal dominant insulinomatosis and nine people with sporadic… Read more »

HbA1c, wound healing unrelated in diabetic foot ulcers

Wound healing was not associated with nadir A1C or mean A1C change from baseline among patients with long-term diabetic foot ulcers and a baseline A1C of 7.5% or less, according to a study in Diabetes Care. Researchers analyzed data from 270 DFU patients and found a correlation between accelerated long-term wound healing and increases in… Read more »

Canada OKs insulin pump system from Medtronic unit

Health Canada granted a license to Medtronic Canada’s MiniMed 630G insulin pump system for treating patients with diabetes mellitus. The system, which is expected to be released in the country early next year, alerts patients when its sensor is at a preset low threshold and suspends insulin delivery when the user is not responsive to… Read more »

Study looks at antidiabetes drug prescribing trends in the US

The use of metformin as a first-line therapy among type 2 diabetes patients increased from 60%of patients in 2005 to 77% in 2016, while use of sulfonylureas declined from 20% to 8% and insulin use rose from 8% to 10%, according to a study in Diabetes Care. Researchers evaluated data on 1,023,340 adults from the US… Read more »

Pediatric obesity prevalence increasing in the US

The rate of US youths ages 2 to 19 who were obese rose from 14% in 1999 to 18.5% in2015 and 2016, with the most significant increase among those ages 2 to 5,researchers reported in Pediatrics. The findings also showed asignificantly higher obesity risk among Hispanics and African-Americans,compared with whites. National Public Radio (2/26),  Consumer Reports online (2/26)  

Study links diabetes risk to fasting plasma glucose variability

A study in Diabetes Care showed a 24% increased risk for type 2 diabetes for every one standard deviation increase in fasting plasma glucose coefficient of variation. Researchers evaluated data from the Korean National Health Insurance System involving 131,744 people without diabetes at baseline and found that older males who completed little physical activity, had… Read more »

Study examines prevalence of diabetes among US veterans

Researchers analyzed data from the National Health and Nutrition Examination Survey from 2005 to 2014 and found that the overall prevalence of diabetes and undiagnosed diabetes among US veterans was 20.5% and 3.4%, respectively, in 2013 to 2014. The findings in the CDC’s Preventing Chronic Disease revealed that diabetes prevalence increased from 15.5% in 2005 to 2006… Read more »

Excess weight, obesity affects more than 2 billion people worldwide

A study in The New England Journal of Medicine found that 2.2 billion people, or 30% of the world’s population, were overweight or obese in 2015, including nearly 108 million obese youths. The findings, based on 1980 to 2015 data from 195 countries, also showed that the US had the highest obesity rate among children… Read more »

More sleep may lower type 2 diabetes risk in youths

Nine- and 10-year-olds who got an additional hour of sleep during weekdays had a 2.9% reduction in insulin resistance, 0.24% lower fasting glucose and 0.19% lower body mass index, which are risk factors for type 2 diabetes, compared with those who got less sleep, UK researchers reported in Pediatrics. However, the findings didn’t show a… Read more »