Quantitative and Functional Proteomics Core

The overall goals of the Quantitative and Functional Proteomics Core are to provide the powerful tools of modern mass spectrometry and complex data set analysis to Diabetes Research Center investigators to permit structural identification and quantitation of proteins involved in diabetes and its complications.

To accomplish these goals the Quantitative and Functional Proteomics Core provides the following to Diabetes Research Center affiliate investigators:

  • ┬áMass spectrometric (MS) analyses for Diabetes Research Center investigators, such as quantifying target analytes and obtaining spectra for structural identification of proteins. Technologies include electrospray ionization tandem mass spectrometry (ESI-MS/MS).
  • Collaborative research studies involving Core staff and Diabetes Research Center affiliates.
  • Development of new MS methods for structural identification or quantification of biomolecules involved in the pathogenesis of diabetes and its complications, risk factors, or treatment.
  • A central facility for data storage, dissemination, and sharing.
  • Training in principles of MS and LCMS and data analysis and interpretation.,.
  • Bioinformatics support for analyzing and interpreting proteomic data sets and for integrating them with Gene Ontology, protein-protein interaction databases, and pathway analysis.
  • Integration of proteomic studies with functional studies, providing an integrated view of diabetes and diabetes-related disease processes.