Vector and Transgenic Mouse Core

The overall goal of the VTMC is to provide DRC affiliate investigators with state-of-the-art vectors necessary to overexpress, knockdown, knockout, or alter expression of RNAs and proteins of interest in cultured cells, isolated tissues, and animals.
To accomplish this goal the VTMC provides the following to DRC affiliate investigators:
  • Production of lentivirus vectors, adeno associated virus (AAV) vectors, retrovirus (MMLV) vectors and adenovirus vectors for use in animals, tissues and cells;
  • CRISPR/Cas9-directed gene editing;
  • Production of lentiviral constructs for generation of transgenic and knockdown mice;
  • Production of non-viral vectors for generation of transgenic, knockout, and knockin mice;
  • Specialized molecular biology methods not routinely performed in affiliate investigators’ laboratories;
  • Cost-effective production of genetically engineered mice through the University of Washington (UW) Transgenic Resources Program;
  • Consultation and training  


If the DRC has supported your research in any way, please support us by citing the DRC grant number P30DK017047 in the acknowledgment section of your publications.

DRC Administrative Office, University of Washington Box 358285 | Phone: 206 764-2688 | FAX: 206 764-2693 |

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