The Center draws upon the expertise of a wide range of investigators with complementary interests in diabetes, obesity, inflammation, lipid metabolism and atherosclerosis. Members of the Center’s faculty conduct both basic research to clarify the mechanisms causing diabetes and obesity and their consequences, and translational research to transform their research findings into clinical solutions.
Two-thirds of the adult U.S. population is overweight and one-half of those individuals – one-third of the adult population – are obese. The prevalence of type 2 diabetes (formerly known as “adult-onset”) has also increased markedly in recent decades not only among adults, but in children as well. Although type 1 diabetes is less common, it is a potentially devastating disorder affecting both children and adults and, while treatments for both types of diabetes exist, neither is curable and effective treatments for obesity have yet to be developed.
Much of the good we accomplish is made possible by private support: by people and organizations underwriting leading-edge research and providing funding to train promising fellows. With your help, the DOCE is improving lives throughout the Northwest and around the world.
Dr. Chang Yeop Han, PhD, is first author and Dr. Alan Chait, MD, is senior author on the article article entitled “Serum amyloid A impairs the anti-inflammatory properties of HDL”, published in the December 2015 issue of The Journal of Clinical Investigation.…
Dr. Michael Schwartz is collaborating with Novo Nordisk on a three-year project to explore the role of the brain in regulating blood glucose and obesity. The collaboration aims to understand factors mediating brain control of blood glucose and appetite with the ultimate goal of developing new therapeutic agents for the treatment of diabetes and obesity.…
The project, entitled Obesity and Arterial Metabolism, focuses on the overall hypothesis is that expression of the glucose transporter GLUT1 is of critical importance for the obesity-induced arterial metabolic signature, smooth muscle cell phenotype, and obesity-accelerated atherosclerosis.
The focus of the program project is to investigate whether diabetes causes high-density lipoprotein to lose its cardioprotective effects and whether this contributes to the increased cardiovascular disease risk associated with diabetes.
Drs. Wang Wang and Ian Sweet have been awarded an American Diabetes Association Innovative Award for their project entitled ‘Source and sites of action of hydrogen peroxide in mitochondria and cytosol of pancreatic islets’.
Dr. Ian Sweet has been awarded an NIH Small Business Technology Transfer (STTR) award for his project entitled ‘Continuous measurement of cell growth as an optimal tool in drug toxicity testing’.
The article, entitled “Diabetes & Obesity via the Brain” focuses on the Schwartz Laboratory’s use of optogentics to understand the neurocircuitry activated in diabetes with the goal to develop new opportunities to treat or prevent the disease
Dr. Christiane Hampe has received an award from the National Ataxia Foundation for her project entitled Glutamate Decarboxylase in Cerebellar Ataxia.