UW Diabetes Institute Researchers Published in Journal of Clinical Investigation

Dr. Chang Yeop Han, PhD, is first author and Dr. Alan Chait, MD, is senior author on the article article entitled “Serum amyloid A impairs the anti-inflammatory properties of HDL”, published in the December 2015 issue of The  Journal of Clinical Investigation. The article reports findings indicating that inflammation results in a loss of the antiinflammatory properties of HDL on adipocytes, which appears to partially result from the SAA component of HDL binding to cell-surface proteoglycans, thereby preventing access of HDL to the plasma membrane. Other UW Diabetes Institute investigators co-authoring the paper include Chongren Tang, PhD, Baohai Shao, PhD, Savitha Subramanian, MD, Tomas Vaisar, PhD and William Osborne, PhD.