Atypical PKC paper published in Diabetes

Dr. Mauricio Dorfman, PhD, is first author and Dr. Joshua Thaler, MD, PhD is senior author on the article entitled “Deletion of Protein Kinase C Lambda in POMC Neurons Predisposes to Diet-Induced Obesity”, published in the January 2017 issue of Diabetes. The article reports that reduced signaling by atypical protein kinase C lambda in POMC neurons lowers leptin responsiveness and melanocortin content, resulting in increased predisposition to diet-induced obesity. Other UW Diabetes Institute investigators co-authoring the paper include Gregory Morton, PhD and Michael Schwartz, MD.