Astrocyte inflammation and obesity paper accepted at Molecular Metabolism

Dr. John Douglass, PhD, is first author and Dr. Joshua Thaler, MD, PhD is senior author on the article entitled “Astrocyte IKKβ/NF-κB signaling is required for diet-induced obesity and hypothalamic inflammation”, in press at Molecular Metabolism. The article reports the the first direct evidence that astrocyte-mediated inflammation promotes susceptibility to weight gain from high-fat diet feeding, suggesting a nonneuronal CNS cellular target for obesity therapeutics.