Dr. Gregory Morton, PhD, has been awarded a competing renewal for his NIH R01 project entitled “CNS mechanisms governing diabetic hyperglycemia”. This 5-year, $1.25M award seeks to identify the neuroendocrine mechanisms and associated neurocircuits that drive diabetic hyperglycemia and delineate how these effects occur. Dr. Morton is a Research Associate Professor of Medicine, Division of Metabolism, Endocrinology and Nutrition and Director, UW Nutrition Obesity Research Center Energy Balance Core.
Dr. Francis Kim, MD, has been awarded an NIH R01 grant for his project entitled “Endothelial nitric oxide synthase and regulation of macrophage function”. This 4-year award investigates the novel hypothesis that macrophage Nos3/NO is required to maintain hepatic insulin sensitivity through its effects on macrophage activation and myelopoiesis, and that the loss of these effects of NO leads to obesity-associated hepatic insulin resistance. Dr. Kim is an Associate Professor of Medicine, Division of Cardiology.
Dr. Mauricio Dorfman, PhD, has been awarded an American Heart Association Scientist Development Grant for his project entitled “Sex-specific microglial signaling in the pathogenesis of obesity and diabetes.” This 4-year award seeks to elucidate the relationship between estrogen and CNS inflammatory signaling and explore the potential for targeting microglial activity to treat obesity and its associated metabolic disorders. Dr. Dorfman is a Research Assistant Professor of Medicine, Division of Metabolism, Endocrinology and Nutrition.
Dr. Michael Schwartz, MD, has been featured by several prominent news organizations in recent weeks to discuss the pathogenesis of obesity in long-term weight loss (click on the links below for full details):
Dr. Schwartz is the RH Williams Endowed Chair in Medicine, Professor, Division of Metabolism, Endocrinology and Nutrition, Director, UW Nutrition Obesity Research Center.
Michael Schwartz, MD, presented a lecture entitled “Brain control of blood sugar and the future of diabetes treatment” at the UW Department of Medicine Grand Rounds on April 28, 2016. Click here to view the full lecture. Dr. Schwartz is the RH Williams Endowed Chair in Medicine, Professor, Division of Metabolism, Endocrinology and Nutrition, Director, UW Nutrition Obesity Research Center.
Dr. Jenny Kanter has been awarded an Innovative Basic Science Award from the American Diabetes Association for her project entitled “Diabetes and Myocardial Infarction – Do They Synergize to Accelerate Atherosclerosis?” This 3-year project will study the mechanisms whereby immune cells accumulate in the artery wall and the role it plays in diabetes-accelerated cardiovascular disease. Dr. Kanter is a Research Assistant Professor of Medicine, Division of Metabolism, Endocrinology and Nutrition.
Dr. Chang Yeop Han, PhD, is first author and Dr. Alan Chait, MD, is senior author on the article article entitled “Serum amyloid A impairs the anti-inflammatory properties of HDL”, published in the December 2015 issue of The Journal of Clinical Investigation. The article reports findings indicating that inflammation results in a loss of the antiinflammatory properties of HDL on adipocytes, which appears to partially result from the SAA component of HDL binding to cell-surface proteoglycans, thereby preventing access of HDL to the plasma membrane. Other UW Diabetes Institute investigators co-authoring the paper include Chongren Tang, PhD, Baohai Shao, PhD, Savitha Subramanian, MD, Tomas Vaisar, PhD and William Osborne, PhD.
The Diabetes Research Center (DRC) is soliciting applications for the Pilot & Feasibility and Stroum Graduate Fellowship Awards. The calls are attached and also available at the DRC website: https://depts.washington.edu/diabetes/currentfundingapplication
Letters of Intent and reviewer nomination forms must be submitted using the online forms and are due by January 04, 2016. The deadline for applications is February 16, 2016.
DOCE Director Michael Schwartz, MD and Novo Nordisk collaborate on exploring the role of the brain in regulating blood glucose and obesity
Dr. Michael Schwartz is collaborating with Novo Nordisk on a three-year project to explore the role of the brain in regulating blood glucose and obesity. The collaboration aims to understand factors mediating brain control of blood glucose and appetite with the ultimate goal of developing new therapeutic agents for the treatment of diabetes and obesity. The research will be conducted at UW Medicine’s South Lake Union research campus in Seattle, Washington and at Novo Nordisk’s research facilities in Måløv, Denmark. Over the next three years, Dr. Schwartz and his team together with Novo Nordisk researchers will conduct a research program on the effect of known hormonal factors working in the brain to regulate whole body glucose metabolism and appetite. Dr. Schwartz is the Robert H. Williams Endowed Chair in Medicine, Professor, Division of Metabolism, Endocrinology and Nutrition.
Read the full press release here