Dr. Mauricio Dorfman, PhD, is first author and Dr. Joshua Thaler, MD, PhD is senior author on the article entitled “Sex differences in microglial CX3CR1 signaling determine obesity susceptibility in mice”, in press at Nature Communications. The article reports the the first direct evidence that microglia can modulate energy homeostasis and obesity susceptibility over the long term in a sex-specific manner. The findings also identify CX3CR1 as a novel nonneuronal CNS target for obesity therapeutics. Other UW Diabetes Institute investigators co-authoring the paper include Gregory Morton, PhD.
Dr. Gregory Morton, PhD, has been awarded a competing renewal for his NIH R01 project entitled “CNS mechanisms governing diabetic hyperglycemia”. This 5-year, $1.25M award seeks to identify the neuroendocrine mechanisms and associated neurocircuits that drive diabetic hyperglycemia and delineate how these effects occur. Dr. Morton is a Research Associate Professor of Medicine, Division of Metabolism, Endocrinology and Nutrition and Director, UW Nutrition Obesity Research Center Energy Balance Core.
Dr. Francis Kim, MD, has been awarded an NIH R01 grant for his project entitled “Endothelial nitric oxide synthase and regulation of macrophage function”. This 4-year award investigates the novel hypothesis that macrophage Nos3/NO is required to maintain hepatic insulin sensitivity through its effects on macrophage activation and myelopoiesis, and that the loss of these effects of NO leads to obesity-associated hepatic insulin resistance. Dr. Kim is an Associate Professor of Medicine, Division of Cardiology.
Dr. Mauricio Dorfman, PhD, has been awarded an American Heart Association Scientist Development Grant for his project entitled “Sex-specific microglial signaling in the pathogenesis of obesity and diabetes.” This 4-year award seeks to elucidate the relationship between estrogen and CNS inflammatory signaling and explore the potential for targeting microglial activity to treat obesity and its associated metabolic disorders. Dr. Dorfman is a Research Assistant Professor of Medicine, Division of Metabolism, Endocrinology and Nutrition.
Dr. Michael Schwartz, MD, has been featured by several prominent news organizations in recent weeks to discuss the pathogenesis of obesity in long-term weight loss (click on the links below for full details):
Dr. Schwartz is the RH Williams Endowed Chair in Medicine, Professor, Division of Metabolism, Endocrinology and Nutrition, Director, UW Nutrition Obesity Research Center.
Dr. Jenny Kanter has been awarded an Innovative Basic Science Award from the American Diabetes Association for her project entitled “Diabetes and Myocardial Infarction – Do They Synergize to Accelerate Atherosclerosis?” This 3-year project will study the mechanisms whereby immune cells accumulate in the artery wall and the role it plays in diabetes-accelerated cardiovascular disease. Dr. Kanter is a Research Assistant Professor of Medicine, Division of Metabolism, Endocrinology and Nutrition.