Dr. Michael Schwartz has been awarded an American Diabetes Association Basic Science Award for his project “Novel Anti-Diabetic Actions of Hypothalamic FGF19-FGFR1 Signaling”. The proposal stems from the finding that FGF19 action in the brain rapidly, potently and selectively increases insulin-independent glucose disposal identifies a novel, CNS-driven mechanism with translational implications for both the pathogenesis and treatment of human diabetes. Studies in this proposal seek to clarify how this occurs and the extent to which it explains the anti-diabetic effect of bariatric surgical procedures.
Dr. Michael Schwartz is first author of a review in Nature, titled “Cooperation between brain and islet in glucose homeostasis and diabetes.” The paper introduces a conceptual advance in our understanding of how blood sugar is controlled and how diabetes occurs, based on new information about the role of the brain and its interaction with pancreatic islets in this control process. DOCE researcher Dr. Gregory Morton,PhD, is co-author on the publication. Dr. Schwartz is the Director of the Diabetes and Obesity Center of Excellence and RH Williams Professor of Medicine in the Division of Metabolism, Endocrinology and Nutrition. Read more in UW Today
Dr. Joshua Thaler is the recipient of a 2013 UW Research Royalty Award for his project entitled “The Role of Hypothalamic Atypical Protein Kinase C in Body Weight Regulation and Glucose Homeostasis“. The focus of the project is to understand the function of atypical PKC in hypothalamic signaling pathways that regulate energy balance and glucose metabolism. Dr. Thaler is an Assistant Professor of Medicine in the Division of Metabolism, Endocrinology and Nutrition.
Dr. Laura den Hartigh has been awarded an NIH K01 for her project entitled “Alterations in Adipocyte Lipid Metabolism by Trans-10, Cis-12 CLA Supplementation”. The project examines the mechanisms by which 10,12CLA confers resistance to diet-induced weight gain in mice, including pathways involved in adipocyte fatty acid oxidation and brown adipogenesis. Dr. den Hartigh is a Research Assistant Professor of Medicine in the Division of Metabolism, Endocrinology and Nutrition
Dr. Karin Bornfeldt is the recipient of a Pilot and Feasibility award from the NIDDK-sponsored Diabetic Complications Consortium. Her project, entitled Diabetes and miRNA, studies the role of microRNAs in monocyte and macrophage activation in diabetic mouse models. Dr. Bornfeldt is a Professor of Medicine in the Division of Metabolism, Endocrinology and Nutrition.
Dr. Ian Sweet is the recipient of the 2013 Gail Patrick Innovation Award from the American Diabetes Association. In honor of Gail Patrick, the first National Chair of the ADA Board of Directors and legendary Motion Picture actress, this award is granted to Innovation award applications to the ADA that receive the highest priority score in a given year. Prestigious awardees receive $50,000 per year for two years to support an innovative idea that advances the Association’s efforts to prevent, treat and cure diabetes and to improve the lives of all people affected by the disease. Dr. Sweet’s project entitled, “Role of cytochrome c translocation in insulin release”, will test whether the movement of cytochrome c is necessary and sufficient to stimulate insulin secretion in the face of elevated calcium signaling. Dr. Sweet is a Research Associate Professor of Medicine in the Division of Metabolism, Endocrinology and Nutrition.
Dr. Joshua Thaler is the 2013 recipient of the Fialkow Award. The Fialkow Award is awarded annually to recognize the outstanding achievements of junior faculty in medicine in research, teaching, clinical work, and academic citizenship. The award honors the late UW Dean of Medicine and Chair of Medicine Dr. Philip Fialkow and his wife, the late Helen Fialkow. Dr. Thaler will formally receive the award and present his talk at Medicine Grand Rounds in the fall. Dr. Thaler is an Assistant Professor of Medicine in the Division of Metabolism, Endocrinology and Nutrition.
Dr. Joshua Thaler has been selected as the recipient of a 2013 Early Investigators Award by The Endocrine Society. The Early Investigators Awards provide monetary support to assist in the development of early career investigators and recognition of their accomplishments in endocrine research. Dr. Thaler’s research focus is the hypothalamic regulation of energy homeostasis and the alterations to this system during obesity pathogenesis. Dr. Thaler is an Assistant Professor of Medicine in the Division of Metabolism, Endocrinology and Nutrition.
Dr. Christiane Hampe, PhD, is the recipient of a 4-year research award from the US-Israel Binational Science Foundation (BSF). Her project, entitled “Depletion of autoreactive-B lymphocytes through anti-idiotypic antibodies coupled to cytotoxins: a new approach for the prevention of Type 1 Diabetes”, focuses on the hypotheses that autoantibody-specific anti-Id can be used as a tool in the development of a new therapy for prevention of T1D. Dr. Hampe is Associate Professor of Medicine in the Division of Metabolism, Endocrinology and Nutrition.
Dr. Christiane Hampe, PhD, has been awarded an NIH R01 for her project entitled “Islet Cell Membrane Antibodies in Diabetes”. The goals of this research are a) to investigate anti-idiotypic antibodies (anti-Id) directed against autoantibodies to glutamate decarboxylase (GAD65Ab) in human Type 1 Diabetes (T1D), and b) to develop anti-Id as a therapeutic tool for the elimination of GAD65-specific B lymphocytes. The results from this project will be crucial for the further development of a novel preventative therapy. Dr. Hampe is Associate Professor of Medicine, Division of Metabolism, Endocrinology and Nutrition.