DOCE Researcher Joshua Thaler, MD, PhD, Receives NIH R03

Dr. Joshua Thaler has been awarded an NIH R03 for his project entitled “Glial-neuronal metabolic coupling in obesity”. This proposal focuses on lactate signaling between hypothalamic astrocytes and neurons. The data obtained from these investigations will form the basis of a new line of research centered on glial-neuronal metabolic coupling as a novel obesity target. Dr. Thaler is an Assistant Professor of Medicine, Division of Metabolism, Endocrinology and Nutrition.

DOCE Director Michael Schwartz, MD, Receives NIH R01

DOCE Director Dr. Michael Schwartz has been awarded a 5-year NIH R01 for his project “Novel Anti-Diabetic Actions of Hypothalamic FGF19-FGFR1 Signaling”. The proposal stems from the finding by the Schwartz laboratory that FGF19 action in the brain rapidly, potently and selectively increases insulin-independent glucose disposal identifies a novel, CNS-driven mechanism with translational implications for both the pathogenesis and treatment of human diabetes. Studies in this proposal seek to clarify how this occurs and the extent to which it explains the anti-diabetic effect of bariatric surgical procedures.

DOCE Director Michael Schwartz, MD, Receives ADA Basic Science Award

Dr. Michael Schwartz has been awarded an American Diabetes Association Basic Science Award for his project “Novel Anti-Diabetic Actions of Hypothalamic FGF19-FGFR1 Signaling”. The proposal stems from the finding that FGF19 action in the brain rapidly, potently and selectively increases insulin-independent glucose disposal identifies a novel, CNS-driven mechanism with translational implications for both the pathogenesis and treatment of human diabetes. Studies in this proposal seek to clarify how this occurs and the extent to which it explains the anti-diabetic effect of bariatric surgical procedures.

DOCE Associate Director Karin Bornfeldt, PhD, Awarded 2013 Russell Ross Memorial Lectureship in Vascular Biology

Dr. Karin Bornfeldt, PhD, has been awarded the 2013 Russell Ross Memorial Lectureship in Vascular Biology. The lecture was delivered at the American Heart Association’s Annual Sessions in Dallas on November 19th. The Ross Lecture is one of three ATVB named lectures presented annually at the American Heart Association’s Scientific Sessions. The lectureship is named after Dr. Russell Ross, Professor and former Chair of Pathology at the UW. Dr. Bornfeldt is a Professor of Medicine in the Division of Metabolism, Endocrinology and Nutrition and Professor of Pathology.

DOCE Director Michael Schwartz, MD, Published in Nature

Dr. Michael Schwartz is first author of a review in Nature, titled “Cooperation between brain and islet in glucose homeostasis and diabetes.” The paper introduces a conceptual advance in our understanding of how blood sugar is controlled and how diabetes occurs, based on new information about the role of the brain and its interaction with pancreatic islets in this control process. DOCE researcher Dr. Gregory Morton,PhD, is co-author on the publication. Dr. Schwartz is the Director of the Diabetes and Obesity Center of Excellence and RH Williams Professor of Medicine in the Division of Metabolism, Endocrinology and Nutrition.  Read more in UW Today

 

DOCE Researcher Joshua Thaler, MD, PhD, Receives UW Research Royalty Award

Dr. Joshua Thaler is the recipient of a 2013 UW Research Royalty Award for his project entitled “The Role of Hypothalamic Atypical Protein Kinase C in Body Weight Regulation and Glucose Homeostasis“. The focus of the project is to understand the function of atypical PKC in hypothalamic signaling pathways that regulate energy balance and glucose metabolism. Dr. Thaler is an Assistant Professor of Medicine in the Division of Metabolism, Endocrinology and Nutrition.

DOCE Researcher Laura den Hartigh, PhD, Receives NIH K01 Award

Dr. Laura den Hartigh has been awarded an NIH K01 for her project entitled “Alterations in Adipocyte Lipid Metabolism by Trans-10, Cis-12 CLA Supplementation”.  The project examines the mechanisms by which 10,12CLA confers resistance to diet-induced weight gain in mice, including pathways involved in adipocyte fatty acid oxidation and brown adipogenesis. Dr. den Hartigh is a Research Assistant Professor of Medicine in the Division of Metabolism, Endocrinology and Nutrition

DOCE Associate Director Karin Bornfeldt, PhD, Receives NIDDK Pilot and Feasibility Award

Dr. Karin Bornfeldt is the recipient of a Pilot and Feasibility award from the NIDDK-sponsored Diabetic Complications Consortium. Her project, entitled Diabetes and miRNA,  studies the role of microRNAs in monocyte and macrophage activation in diabetic mouse models. Dr. Bornfeldt is a Professor of Medicine in the Division of Metabolism, Endocrinology and Nutrition.

DOCE Researcher Ian Sweet, PhD, Receives ADA Gail Patrick Innovation Award

Dr. Ian Sweet is the recipient of the 2013 Gail Patrick Innovation Award from the American Diabetes Association. In honor of Gail Patrick, the first National Chair of the ADA Board of Directors and legendary Motion Picture actress, this award is granted to Innovation award applications to the ADA that receive the highest priority score in a given year. Prestigious awardees receive $50,000 per year for two years to support an innovative idea that advances the Association’s efforts to prevent, treat and cure diabetes and to improve the lives of all people affected by the disease. Dr. Sweet’s project entitled, “Role of cytochrome c translocation in insulin release”, will test whether the movement of cytochrome c is necessary and sufficient to stimulate insulin secretion in the face of elevated calcium signaling. Dr. Sweet is a Research Associate Professor of Medicine in the Division of Metabolism, Endocrinology and Nutrition.

DOCE Researcher Joshua Thaler, MD, PhD, Receives 2013 Fialkow Award

Dr. Joshua Thaler is the 2013 recipient of the Fialkow Award. The Fialkow Award is awarded annually to recognize the outstanding achievements of junior faculty in medicine in research, teaching, clinical work, and academic citizenship. The award honors the late UW Dean of Medicine and Chair of Medicine Dr. Philip Fialkow and his wife, the late Helen Fialkow. Dr. Thaler will formally receive the award and present his talk at Medicine Grand Rounds in the fall. Dr. Thaler is an Assistant Professor of Medicine in the Division of Metabolism, Endocrinology and Nutrition.