DOCE researchers published in Cell Reports

DOCE Associate Director Karin Bornfeldt, PhD is senior author of an article published in the April issue of Cell Reports (Cell Press). This article, entitled “Testing the Role of Myeloid Cell Glucose Flux in Inflammation and Atherosclerosis”, demonstrates that increased glucose flux in macrophages and other myeloid cells does not contribute to inflammation and atherosclerosis in vivo. These findings have important implications for studies on diabetic vascular disease; a multifactorial disease in which the role of glucose is still uncertain. The article was also featured in the April 10th issue of Cell Reports: “Getting to the cardiovascular heart of diabetes: Q&A with Karin Bornfeldt”. DOCE researcher Jenny Kanter, PhD, is co-author on the article.

 

DOCE Director Dr. Michael Schwartz Awarded 2014 Hammond Memorial Lecture

DOCE Director Michael Schwartz, MD, has been selected to give the 7th Annual Levi J. Hammond Distinguished Memorial Lecture. This annual lecture was held at the University of Pennsylvania on May  13, 2014.

DOCE Researchers published in Nature Reviews Neuroscience

DOCE Director Michael Schwartz, MD, is senior author on a review article published in the May issue of  Nature Review Neuroscience. The article entitled “Neurobiology of food intake in health and disease” highlights how the interplay between homeostatic and emergency feeding circuits influences the biologically defended level of body weight under physiological and pathophysiological conditions. DOCE researchers Gregory Morton, PhD is first author and Thomas Meek, PhD is co-author.

DOCE Associate Director Karin Bornfeldt, PhD, Awarded 2014 Edwin Bierman Lectureship

Dr. Karin Bornfeldt, PhD, has been awarded the 2014 Edwin Bierman Lectureship. The lecture will be delivered at the American Diabetes Association’s Annual Sessions in San Francisco, June 16th. The award and lecture recognize a leading scientist in the field of macrovascular complications and contributing risk factors in diabetes. Click here for more information. Dr. Bornfeldt is a Professor of Medicine in the Division of Metabolism, Endocrinology and Nutrition and Professor of Pathology.

DOCE Director Michael Schwartz, MD, Receives NIH R01

DOCE Director Dr. Michael Schwartz has been awarded a 5-year NIH R01 for his project “Novel Anti-Diabetic Actions of Hypothalamic FGF19-FGFR1 Signaling”. The proposal stems from the finding by the Schwartz laboratory that FGF19 action in the brain rapidly, potently and selectively increases insulin-independent glucose disposal identifies a novel, CNS-driven mechanism with translational implications for both the pathogenesis and treatment of human diabetes. Studies in this proposal seek to clarify how this occurs and the extent to which it explains the anti-diabetic effect of bariatric surgical procedures.

DOCE Director Michael Schwartz, MD, Receives ADA Basic Science Award

Dr. Michael Schwartz has been awarded an American Diabetes Association Basic Science Award for his project “Novel Anti-Diabetic Actions of Hypothalamic FGF19-FGFR1 Signaling”. The proposal stems from the finding that FGF19 action in the brain rapidly, potently and selectively increases insulin-independent glucose disposal identifies a novel, CNS-driven mechanism with translational implications for both the pathogenesis and treatment of human diabetes. Studies in this proposal seek to clarify how this occurs and the extent to which it explains the anti-diabetic effect of bariatric surgical procedures.

DOCE Associate Director Karin Bornfeldt, PhD, Awarded 2013 Russell Ross Memorial Lectureship in Vascular Biology

Dr. Karin Bornfeldt, PhD, has been awarded the 2013 Russell Ross Memorial Lectureship in Vascular Biology. The lecture was delivered at the American Heart Association’s Annual Sessions in Dallas on November 19th. The Ross Lecture is one of three ATVB named lectures presented annually at the American Heart Association’s Scientific Sessions. The lectureship is named after Dr. Russell Ross, Professor and former Chair of Pathology at the UW. Dr. Bornfeldt is a Professor of Medicine in the Division of Metabolism, Endocrinology and Nutrition and Professor of Pathology.

DOCE Director Michael Schwartz, MD, Published in Nature

Dr. Michael Schwartz is first author of a review in Nature, titled “Cooperation between brain and islet in glucose homeostasis and diabetes.” The paper introduces a conceptual advance in our understanding of how blood sugar is controlled and how diabetes occurs, based on new information about the role of the brain and its interaction with pancreatic islets in this control process. DOCE researcher Dr. Gregory Morton,PhD, is co-author on the publication. Dr. Schwartz is the Director of the Diabetes and Obesity Center of Excellence and RH Williams Professor of Medicine in the Division of Metabolism, Endocrinology and Nutrition.  Read more in UW Today

 

DOCE Researcher Joshua Thaler, MD, PhD, Receives UW Research Royalty Award

Dr. Joshua Thaler is the recipient of a 2013 UW Research Royalty Award for his project entitled “The Role of Hypothalamic Atypical Protein Kinase C in Body Weight Regulation and Glucose Homeostasis“. The focus of the project is to understand the function of atypical PKC in hypothalamic signaling pathways that regulate energy balance and glucose metabolism. Dr. Thaler is an Assistant Professor of Medicine in the Division of Metabolism, Endocrinology and Nutrition.

DOCE Researcher Laura den Hartigh, PhD, Receives NIH K01 Award

Dr. Laura den Hartigh has been awarded an NIH K01 for her project entitled “Alterations in Adipocyte Lipid Metabolism by Trans-10, Cis-12 CLA Supplementation”.  The project examines the mechanisms by which 10,12CLA confers resistance to diet-induced weight gain in mice, including pathways involved in adipocyte fatty acid oxidation and brown adipogenesis. Dr. den Hartigh is a Research Assistant Professor of Medicine in the Division of Metabolism, Endocrinology and Nutrition