Our Research: Faculty/Research Laboratories

Brent Wisse, MD

Associate Professor, Department of Medicine, Division of Metabolism, Endocrinology and Nutrition

Email Address: bewisse@u.washington.edu

Division of Metabolism, Endocrinology and Nutrition Website:  http://depts.washington.edu/metab/

Brent Wisse, MD

Background:

Dr. Wisse received his MD and Internal Medicine training at McGill University in 1995 before completing his fellowship training in Endocrinology and Metabolism at the UW.  During his fellowship, Dr. Wisse worked with with Dr. David Cummings and Dr. Michael Schwartz.  Dr. Wisse joined the UW Faculty in 2001 and he enjoys clinical teaching and patient care responsibilities at Harborview Medical Center (HMC) in Seattle, and also has served as Director of the HMC Glycemic Control Service since 2007. His research program focuses on the intersection between inflammatory signals and energy homeostasis and is a member of the Western Federation of Medical Research, the Endocrine Society, and The Obesity Society. His research efforts have been NIH funded since 2001.

Focus:

Dr. Wisse’s research focuses on the following areas:

Central pathways regulating anorexia and cachexia
This area has been a principal research focus, identifying key CNS signals whereby systemic inflammatory mediators cause anorexia and weight loss, including cachexia – the specific wasting of skeletal muscle.
Diabetes and Obesity Center of Excellence Collaborators include: Michael Schwartz, MD; Greg Morton, PhD; Renee Leboeuf, PhD; and Jay Heinecke, MD.

Nutrient excess as an inflammatory stimulus
This program focuses on the response of hypothalamic cell lines and primary neuronal cultures to excess nutrients from glucose or fatty acids.
Diabetes and Obesity Center of Excellence Collaborators include: Francis Kim, MD; Michael Schwartz, MD; Greg Morton, PhD; Ian Sweet, PhD; and Jay Heinecke, MD.

Regulation of Spontaneous Physical Activity (SPA) in mice
A new area of interest, this program is designed to identify the physiological regulators of voluntary activity and the influence on non-resting energy expenditure and body weight regulation in mice.
Diabetes and Obesity Center of Excellence Collaborators include: Michael Schwartz, MD; Greg Morton, PhD, Karl Kaiyala, PhD, Renee LeBoeuf, PhD.

Representative Publications:

Wisse BE, Ogimoto K, Schwartz MW. Role of hypothalamic interleukin-1beta (IL-1beta) in regulation of energy homeostasis by melanocortins. Peptides. 27:265-273, 2006.

Ogimoto K, Harris MK Jr, Wisse BE. MyD88 is a key mediator of anorexia, but not weight loss, induced by lipopolysaccharide and interleukin-1 beta. Endocrinology. 147:4445-4553, 2006.

Wisse BE, Ogimoto K, Morton GJ, Williams DL, Schwartz MW. Central interleukin-1 (IL1) signaling is required for pharmacological, but not physiological, effects of leptin on energy balance. Brain Res. 1144:101-106, 2007.

Wisse BE, Ogimoto K, Tang J, Harris MK Jr, Raines EW, Schwartz MW. Evidence that LPS-induced anorexia depends upon central, rather than peripheral, inflammatory signals.Endocrinology. 148:5230-5237, 2007.

Wisse BE, Kim F, Schwartz MW. Physiology. An integrative view of obesity. Science.318:928-929, 2007.
Wisse BE, Schwartz MW. Does hypothalamic inflammation cause obesity? Cell Metabolism.10:241-242, 2009.

Choi SJ, Kim F, Schwartz MW and Wisse BE. Cultured hypothalamic neurons are resistant to inflammation and insulin resistance induced by saturated fatty acids. Am J Physiology.298:E1122-1130, 2010. PMCID: PMC2886534.

  • You-Ten EK, Seemayer TA, Wisse BE, Lapp WS. Induction of a glucocorticoid sensitive F1 anti-parental mechanism that affects engraftment during graft-versus-host disease. J. Immunol. 155: 172-180, 1995.

    Wisse BE, Campfield LA, Marliss EB, Morais JA, Tenenbaum R, Gougeon R. Effect of prolonged moderate and severe energy restriction and refeeding on plasma leptin concentrations in obese women. Am J Clin Nutr. 70:321-330, 1999.

    Wisse BE, Frayo RS, Schwartz MW, Cummings DE. Reversal of cancer anorexia by blockade of central melanocortin receptors in rats. Endocrinology. 142:3292-3301, 2001.

    Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes. 50:1714-1719, 2001.

    Wisse BE, Schwartz MW. Role of melanocortins in control of obesity. Lancet. 358:857-859, 2001.

    Wisse BE, Schwartz MW. The skinny on neurotrophins. Nat Neurosci. 6:655-656, 2003.

    Wisse BE, Schwartz MW, Cummings DE. Melanocortin signaling and anorexia in chronic disease states. Ann N Y Acad Sci. 994:275-281, 2003.

    Wisse BE, Ogimoto K, Morton GJ, Wilkinson CW, Frayo RS, Cummings DE, Schwartz MW. Physiological regulation of hypothalamic IL-1beta gene expression by leptin and glucocorticoids: implications for energy homeostasis. Am J Physiol Endocrinol Metab.287:E1107-1113, 2004.

    Wisse BE. The inflammatory syndrome: the role of adipose tissue cytokines in metabolic disorders linked to obesity. J Am Soc Nephrol. 15:2792-2800, 2004.

    Wisse BE, Ogimoto K, Schwartz MW. Role of hypothalamic interleukin-1beta (IL-1beta) in regulation of energy homeostasis by melanocortins. Peptides. 27:265-273, 2006.

    Ogimoto K, Harris MK Jr, Wisse BE. MyD88 is a key mediator of anorexia, but not weight loss, induced by lipopolysaccharide and interleukin-1 beta. Endocrinology. 147:4445-4453, 2006.

    Wisse BE, Ogimoto K, Morton GJ, Williams DL, Schwartz MW. Central interleukin-1 (IL1) signaling is required for pharmacological, but not physiological, effects of leptin on energy balance. Brain Res. 1144:1101-6, 2007.

    Wisse BE, Ogimoto K, Tang J, Harris MK Jr, Raines EW, Schwartz MW. Evidence that LPS-induced anorexia depends upon central, rather than peripheral, inflammatory signals.Endocrinology. 148:5230-5237, 2007.

    Klaff LS, Wisse BE. Current controversy related to glucocorticoid and insulin therapy in the intensive care unit. Endocr Pract. 13:542-549, 2007.

    Wisse BE, Kim F, Schwartz MW. Physiology. An integrative view of obesity. Science.318:928-929, 2007.

    Kim F, Pham M, Maloney E, Rizzo N, Morton GJ, Wisse BE, Kirk EA, Chait A, Schwartz MW. Vascular Inflammation, Insulin Resistance and Reduced Nitric Oxide Production Precede the Onset of Peripheral Insulin Resistance. Atheroscler Thromb Vasc Biol. 28:1982-1988, 2008. PMCID: PMC2577575.

    Blevins JE, Morton GJ, Williams DJ, Caldwell DW, Bastian LS, Wisse BE, Schwartz MW, and Baskin DG. Forebrain melanocortin signaling enhances the hindbrain satiety response to CCK-8. Am J Physiol Regul Integr Comp Physiol. 296:R476-484, 2009.

    Wisse BE, Schwartz MW. Does hypothalamic inflammation cause obesity? Cell Metabolism.10:241-242, 2009.

    Thompson R, Schreuder AB, Wisse B, Jarman K, Givan K, Suhr L, Corl D, Pierce B, Knopp R, Goss JR. Improving insulin ordering safely: the development of an inpatient glycemic control program. J Hosp Med. 4:E30-35, 2009.

    Thaler JP, Choi SJ, Sajan MP, Ogimoto K, Nguyen HT, Matsen M, Benoit SC, Wisse BE, Farese RV, Schwartz MW. Atypical protein kinase C activity in the hypothalamus is required for lipopolysaccharide-mediated sickness responses. Endocrinology. 150:5362-5372, 2009. PMCID: PMC2795721.

    Chiu HK, Qian K, Ogimoto K, Morton GJ, Wisse BE, Agrawal N, MacDonald T, Schwartz, MW, Dichek HL.  Mice lacking hepatic lipase are lean and protected against diet-induced obesity and hepatic steatosis. Endocrinology. 151:993-1001, 2010.  PMCID: PMC2840680.

    Kaiyala KJ, Morton GJ, Leroux BG, Ogimoto K, Wisse BE and Schwartz MW. Identification of body fat mass as a major determinant of metabolic rate in mice. Diabetes. 59:1657-1666, 2010. PMCID: PMC2889765.

    Oh-I S, Thaler JP, Ogimoto K, Wisse BE, Morton GJ, and Schwartz MW. Central administration of Interleukin-4 exacerbates hypothalamic inflammation and weight gain during hig-fat feeding. Am J Physiology. 299:E47-53, 2010. PMCID: PMC2904047.

    Choi SJ, Kim F, Schwartz MW and Wisse BE. Cultured hypothalamic neurons are resistant to inflammation and insulin resistance induced by saturated fatty acids. Am J Physiology.298:E1122-1130, 2010. PMCID: PMC2886534.

    German J, Wisse BE, Thaler JP, Oh-I S, Sarruf DA, Ogimoto K, Kaiyala K, Fischer JD, Matsen ME, Taborsky GJ, Schwartz MW, and Morton GJ. Leptin deficiency causes insulin resistance induced by uncontrolled diabetes. Diabetes. 59:1626-1634, 2010. PMCID: PMC2889761.

Current Collaborations:

Within the Diabetes and Obesity Center of Excellence and its Affiliated Members
Michael Schwartz, MD
Greg Morton, PhD
Renee Lebeouf, PhD
Jay Heinecke, MD
Francis Kim, MD
Ian Sweet, PhD
Tomas Vaisar, PhD

Lab Members:

Xiaolin Zhao, MD
JD Fischer, BS
Tracy Tylee, MD