Our Research: Faculty/Research Laboratories

Jenny Kanter, PhD

Research Assistant Professor of Medicine, Division of Metabolism, Endocrinology and Nutrition

Email Address: jenka@u.washington.edu

Division of Metabolism, Endocrinology and Nutrition Website:  http://depts.washington.edu/metab/

Kanter, Jenny

 

Background:

Jenny Kanter received her PhD from the University of Washington in Pathology in 2010, with a specific focus on myeloid cells inflammation in the development of diabetes-accelerated atherosclerosis. She did her postdoctoral training with Dr. Karin Bornfeldt, PhD, at the University of Washington. She is currently a Research Assistant Professor Diabetes and Obesity Center of Excellence at the University of Washington.

Focus:

Diabetes is increasing as a result of increased rates of obesity, and with that complications of diabetes are also on the rise. These include diabetic nephropathy, diabetic retinopathy and macrovascular complications such as atherosclerosis. Dr. Kanter’s research is focused on generating a model in which the majority of these complications can be studied, both the molecular mechanisms that drive the individual complications but also the interaction between them. Further, Dr. Kanter has a long-staining interest in myeloid cells (monocytes and macrophages), and how they get activated under diabetic conditions and their role in acceleration of disease.

 

Representative Publications:

Kanter JE, Johansson F, LeBoeuf RC, Bornfeldt KE (2007): Do glucose and lipids exert independent effects on atherosclerotic lesion initiation or progression to advanced plaques? Circ Res. 100, 769-81.

Kanter JE, Kramer F, Barnhart S, Averill AM, Vivekanandan-Giri A, Vickery T, Li LO, Becker L, Yuan W, Chait A, Braun KR, Potter-Perigo S, Sanda S, Wight TN, Pennathur S, Serhan SN, Heinecke JW, Coleman RA, Bornfeldt KE (2012): Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis via acyl-CoA synthetase. Proc Natl Acad Sci USA. 109, E715-24.

Kanter JE, Bornfeldt KE (2012): Inflammation and diabetes-accelerated atherosclerosis: myeloid cell mediators. Trends Endocrinol Metab. 24,137-44.

Nishizawa T, Kanter JE, Kramer F, Barnhart S, Shen X, Vivekanandan-Giri A, Wall VZ, Kowitz J, Devaraj S, O’Brien KD, Pennathur S, Tang J, Miyaoka RS, Raines EW, Bornfeldt KE (2014): Testing the role of myeloid cell glucose flux in inflammation and atherosclerosis. Cell Rep. 7, 356-65.

  • Kanter JE, Johansson F, LeBoeuf RC, Bornfeldt KE (2007): Do glucose and lipids exert independent effects on atherosclerotic lesion initiation or progression to advanced plaques? Circ Res. 100, 769-81.

    Askari B, Kanter JE, Sherrid AM, Golej DL, Bender AT, Liu J, Hsueh WA, Beavo JA, Coleman RA, Bornfeldt KE (2007): Rosiglitazone inhibits acyl-CoA synthetase activity and fatty acid partitioning to diacylglycerol and triacylglycerol via a peroxisome proliferator-activated receptor-gamma-independent mechanism in human arterial smooth muscle cells and macrophages. Diabetes. 56, 1143-52.

    Johansson F, Kramer F, Barnhart S, Kanter JE, Vaisar T, Merrill RD, Geng L, Oka K, Chan L, Chait A, Heinecke JW & Bornfeldt KE (2008): Type 1 diabetes promotes disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice. Proc Natl Acad Sci USA. 105, 2082-7.

    Kanter JE, Averill MM, Leboeuf RC, Bornfeldt KE (2008): Diabetes-accelerated atherosclerosis and inflammation. Circ Res. 103, e116-7.

    Li S, Sun Y, Liang CP, Thorp EB, Han S, Jehle AW, Saraswathi V, Pridgen B, Kanter JE, Li R, Welch CL, Hasty AH, Bornfeldt KE, Breslow JL, Tabas I & Tall AR (2009): Defective phagocytosis of apoptotic cells by macrophages in atherosclerotic lesions of ob/ob mice and reversal by a fish oil diet. Circ Res. 105, 1072-1082.

    Tang C, Kanter JE, Bornfeldt KE, LeBouef RC & Oram JF (2010): Diabetes reduces the cholesterol exporter ABCA1 in mouse macrophages and kidneys. J. Lipid Res. 51, 1719-28.

    Kanter JE, Tang C, Oram JF, Bornfeldt KE (2012): Acyl-CoA synthetase 1 is required for oleate and linoleate mediated inhibition of cholesterol efflux through ATP-binding cassette transporter A1 in macrophages. Biochim Biophys Acta. 1821, 358-64.

    Kanter JE, Kramer F, Barnhart S, Averill AM, Vivekanandan-Giri A, Vickery T, Li LO, Becker L, Yuan W, Chait A, Braun KR, Potter-Perigo S, Sanda S, Wight TN, Pennathur S, Serhan SN, Heinecke JW, Coleman RA, Bornfeldt KE (2012): Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis via acyl-CoA synthetase. Proc Natl Acad Sci USA. 109, E715-24.

    Kanter JE, Bornfeldt KE (2012): Inflammation and diabetes-accelerated atherosclerosis: myeloid cell mediators. Trends Endocrinol Metab. 24,137-44.

    Li X, Gonzalez O, Shen X, Barnhart S, Kramer F, Kanter JE, Vivekanandan-Giri A, Tsuchiya K, Handa P, Pennathur S, Kim F, Coleman RA, Schaffer JE, Bornfeldt KE (2012): Endothelial Acyl-CoA Synthetase 1 Is Not Required for Inflammatory and Apoptotic Effects of a Saturated Fatty Acid-Rich Environment. Arterioscler Thromb Vasc Biol. 33, 232-40.

    Tateya S, Rizzo-De Leon N, Handa P, Cheng AM, Morgan-Stevenson V, Ogimoto K, Kanter JE, Bornfeldt KE, Daum G, Clowes AW, Chait A, Kim F (2013): VASP increases hepatic fatty acid oxidation by activating AMPK in mice. Diabetes. 62, 1913-22.

    Kanter JE, Bornfeldt KE (2013): Evidence Stacks Up That Endothelial Insulin Resistance Is a Culprit in Atherosclerosis. Circ Research. 113, 352-4.

    Nishizawa T, Kanter JE, Kramer F, Barnhart S, Shen X, Vivekanandan-Giri A, Wall VZ, Kowitz J, Devaraj S, O’Brien KD, Pennathur S, Tang J, Miyaoka RS, Raines EW, Bornfeldt KE (2014): Testing the role of myeloid cell glucose flux in inflammation and atherosclerosis. Cell Rep. 7, 356-65.

Current Collaborations:

Within the Diabetes and Obesity Center of Excellence and its Affiliated Members
Karin Bornfeldt, PhD
Jay Heinecke, MD
Baohai Shao, PhD

Outside of the Diabetes and Obesity Center of Excellence
Charles Alpers, MD, University of Washington
Peter Tontononz, MD, PhD, University of California, Los Angeles