Our Research: Faculty/Research Laboratories

Savitha Subramanian, MD

Assistant Professor, Department of Medicine, Division of Metabolism, Endocrinology and Nutrition

Email Address: ssubrama@u.washington.edu

Division of Metabolism, Endocrinology and Nutrition Website:  http://depts.washington.edu/metab/

Savitha Subramanian, MD

Background:

Dr. Subramanian received her medical degree from Stanley Medical College in Chennai (Madras), India in 1997. She completed a residency in Internal Medicine at the University of Illinois College of Medicine at Urbana-Champaign in 2002. After completing an Endocrinology fellowship at Washington University in St. Louis in 2004, she moved to the University of Washington for a post-doctoral fellowship in the laboratory of Dr. Alan Chait. Since 2006, Dr. Subramanian has been actively involved in the Division’s clinical teaching and patient care responsibilities. Currently she sees patients at Harborview Medical Center in the NW Lipid Clinic, Diabetes and Endocrine clinics.

Focus:

Research in the Subramanian lab broadly focuses on studying the immune mileu tissue depots in obesity primarily using mouse models. Specific areas of research include i) contributory aspects of diet tofat accumulation in the liver (nonalcoholic steatohepatitis) and inflammation in insulin resistance and cardiovascular disease; ii) role of adipose and hepatic mTOR complex 1 and its downstream signaling molecule S6K1 in obesity. iii)a new direction of collaborative research involves evaluating effects of androgens in hepatic lipid accumulation.

 

Representative Publications (selected since 2012):

Ding Y, Subramanian S, Montes VN, Goodspeed L, Wang SA, Han CY, Teresa III AS, Kim J, O’Brien KD, Chait A. Toll-like Receptor-4 Deficiency Decreases Atherosclerosis but Does Not Protect against Inflammation in Obese LDL Receptor-Deficient Mice. Arterioscler Thromb Vasc Biol. 2012 Jul;32(7):1596-604. PMCID: PMC3748807.

Umemoto T*, Subramanian S*, Ding E, Goodspeed L, Wang SA, Han CY, Sta. Teresa A, Kim J, O’Brien KD and Chait A. Ezetimibe inhibits atherosclerosis without reducing adipose tissue inflammation in obese cholesterol-fed LDL receptor deficient mice. *Co-first author. J Lipid Res. 2012 Nov;53(11):2380-9. PMCID: PMC3466006.

Umemoto T, Han CY, Mitra P, Averill M, Tang CR, Goodspeed L, Omer M, Subramanian S, Wang SA, den Hartigh L, Kim E J, Kim J, O’Brien KD, Chait A. Apolipoprotein A-I and HDL have anti-inflammatory effects on adipocytes via cholesterol transporters; ATP-binding cassette (ABC) A-1, ABCG-1 and scavenger receptor B-1(SRB-1). Circ Res 2013 May 10;112(10):1345-54. PMCID: PMC3767575.

Montes VN, Turner MS, Subramanian S, Ding Y, Hayden-Ledbetter M, Slater S, Goodspeed L, Wang S, Omer M, den Hartigh LJ, Averill MM, O’Brien KD, Ledbetter J, Chat A. T cell activation inhibitors reduce CD8+ T cell and pro-inflammatory macrophage accumulation in adipose tissue of obese mice. PLOSOne, 2013 Jul; 8(7)e67709. PMCID: PMC3699637.

Subramanian S*, Turner MS, Ding Y, Goodspeed L, Wang SA, Buckner JH, O’Brien KD, Getz GS, Reardon CA, Chait A. Increased levels of invariant natural killer T lymphocytes worsens metabolic abnormalities and atherosclerosis in obese mice. J Lipid Res, 2013 Oct; 54(10):2831-41. *Corresponding author. PMCID: PMC3770095.

Wei H, Averill M, McMillen T, Dastvan F, Mitra P, Subramanian S, Tang CR, Chait A, LeBoeuf RC. Modulation of Adipose Tissue Lipolysis and Body Weight by High Density Lipoproteins in Mice. Nutrition and Diabetes 2014 Feb 24;4:e108. PMCID: PMC3940828.

Current Collaborations:

Within the Diabetes and Obesity Center of Excellence and its Affiliated Members
Stephanie Page MD, PhD
Katya Rubinow, MD
Alan Chait, MD
Francis Kim, MD
Renee LeBoeuf, PhD

Outside the Diabetes and Obesity Center of Excellence
Kevin O’Brien, MD, University of Washington
Irl Hirsch, Division of Endocrinology, UW
Kevin O’Brien, MD, Division of Cardiology, University of Washington
Raymond Yeung, MD, Department of Surgery, UW
Warren Ladiges, DVM, Department of Comparative Medicine,UW
George Iaonnou, MD, Division of Gastroenterology, UW
Catherine Reardon, PhD, University of Chicago
Godfrey Getz, PhD, University of Chicago
Subramaniam Pennathur, University of Michigan