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Welcome to the Rubinow Laboratory

 

Research

Dr. Rubinow’s work is dedicated to better understanding the metabolic effects of estrogens and androgens, with particular focus on sex steroid signaling in macrophages. Obesity, insulin resistance, and type 2 diabetes are all characterized by altered circulating levels of estrogens and androgens in both men and women. Further, sex steroid deprivation increasingly is recognized as an important risk factor for the development of metabolic disease. Thus, either excessive or inadequate exposure to sex steroids can promote metabolic dysregulation, but the mechanisms by which changes in sex steroid exposure contribute to obesity and diabetes remain poorly understood. Dr. Rubinow’s research is focused on the ways in which altered sex steroid exposure influences macrophage phenotype and function and, further, how metabolic disease might modulate macrophage production of sex steroids. Her current research efforts include a clinical study examining the effects of differential sex steroid exposure on insulin sensitivity, body composition, and adipose tissue biology in men. She also is using in vitro models to better understand the regulation of macrophage steroidogenic enzymes, including aromatase and 5α-reductase.

 

News

Poster presentation at the Endocrine Society’s 96th Annual Meeting and Expo

University of Washington Chair of Medicine Scholars Award recipient, 2013

 

Recent Publications

Rubinow KB, Wall VZ, Nelson J, Mar D, Bomsztyk K, Askari B, Lai MA, Smith KD, Han MS, Vivekanandan-Giri A, Pennathur S, Albert CJ, Ford DA, Davis RJ, Bornfeldt KE. Acyl-CoA synthetase 1 is induced by Gram-negative bacteria and lipopolysaccharide and is required for phospholipid turnover in stimulated macrophages. J Biol Chem. 5;288:9957-9970, 2013.

Rubinow KB, Bornfeldt KE. Microvascular management of systemic insulin sensitivity. Circ Res. 111:951-953, 2012.

Rubinow KB, Vaisar T, Tang C, Matsumoto AM, Heinecke JW, Page ST. Testosterone replacement in hypogonadal men alters the HDL proteome but not HDL cholesterol efflux capacity. J Lipid Res. 53:1376-1383, 2012.

Rubinow KB, Tang C, Hoofnagle AN, Snyder CN, Amory JK, Heinecke JW, Page ST. Acute sex steroid withdrawal increases cholesterol efflux capacity and HDL-associated clusterin in men. Steroids. 77:454-460, 2012.

 

 

Lab Life

 

  • Contact Us

    Address:
    Diabetes and Obesity Center of Excellence
    University of Washington School of Medicine
    South Lake Union Campus
    850 Republican Street Rm S280
    Seattle, WA 98109-8055

    Phone/Fax:
    Fax: (206) 543-3567
    Phone: (206) 616-0720

    Email Addresses:
    Katya Rubinow: rubinow@uw.edu

    Careers

    To inquire about Postdoctoral and Graduate Student Openings click on: rubinow@uw.edu