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Welcome to the Rubinow Laboratory
Dr. Rubinow’s work is dedicated to better understanding the metabolic effects of estrogens and androgens, with particular focus on sex steroid signaling in macrophages. Obesity, insulin resistance, and type 2 diabetes are all characterized by altered circulating levels of estrogens and androgens in both men and women. Further, sex steroid deprivation increasingly is recognized as an important risk factor for the development of metabolic disease. Thus, either excessive or inadequate exposure to sex steroids can promote metabolic dysregulation, but the mechanisms by which changes in sex steroid exposure contribute to obesity and diabetes remain poorly understood. Dr. Rubinow’s research is focused on the ways in which altered sex steroid exposure influences macrophage phenotype and function and, further, how metabolic disease might modulate macrophage production of sex steroids. Her current research efforts include a clinical study examining the effects of differential sex steroid exposure on insulin sensitivity, body composition, and adipose tissue biology in men. She also is using in vitro models to better understand the regulation of macrophage steroidogenic enzymes, including aromatase and 5α-reductase.
Rubinow KB, Wall VZ, Nelson J, Mar D, Bomsztyk K, Askari B, Lai MA, Smith KD, Han MS, Vivekanandan-Giri A, Pennathur S, Albert CJ, Ford DA, Davis RJ, Bornfeldt KE. Acyl-CoA synthetase 1 is induced by Gram-negative bacteria and lipopolysaccharide and is required for phospholipid turnover in stimulated macrophages. J Biol Chem. 5;288:9957-9970, 2013.
Rubinow KB, Bornfeldt KE. Microvascular management of systemic insulin sensitivity. Circ Res. 111:951-953, 2012.
Rubinow KB, Vaisar T, Tang C, Matsumoto AM, Heinecke JW, Page ST. Testosterone replacement in hypogonadal men alters the HDL proteome but not HDL cholesterol efflux capacity. J Lipid Res. 53:1376-1383, 2012.
Rubinow KB, Tang C, Hoofnagle AN, Snyder CN, Amory JK, Heinecke JW, Page ST. Acute sex steroid withdrawal increases cholesterol efflux capacity and HDL-associated clusterin in men. Steroids. 77:454-460, 2012.
Diabetes and Obesity Center of Excellence
University of Washington School of Medicine
South Lake Union Campus
850 Republican Street Rm S280
Seattle, WA 98109-8055
Fax: (206) 543-3567
Phone: (206) 616-0720
Katya Rubinow: firstname.lastname@example.org
To inquire about Postdoctoral and Graduate Student Openings click on: email@example.com