Study Name: Effect of Dietary Glycemic Index on Beta-cell Function
If you have impaired glucose tolerance (IGT) you may be interested in being part of a research study investigating if changing the glycemic index of foods in the diet will change the variability (ups and downs) of the blood sugar and if this has negative effects on insulin secretion in people at risk for diabetes.
Subjects in this study will receive a diet containing either high- or low-glycemic index foods. High glycemic index foods, such as white bread or rice, lead to higher blood sugar levels after a meal, while low glycemic index foods, such as beans or tomatoes, result in lower blood sugar levels after a meal. To test whether “oxidative stress” is a factor affecting insulin secretion on the high glycemic index diet, subjects assigned to the high glycemic index diet will be asked to take either the anti-oxidant N-acetylcysteine (NAC) or a matching placebo twice a day while on the diet. NAC is a dietary supplement sold over-the-counter.
This study is being conducted by investigators at the VA Puget Sound Medical Center, the University of Washington and the Fred Hutchinson Cancer Research Center.
For more information about the study, contact:
Kristina Utzschneider, MD 206-277-3568