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EINet Alert ~ Nov 17, 2006
*****A free service of the APEC Emerging Infections Network*****
APEC EINet News Briefs offers the latest news, journal articles, and notifications for emerging infections affecting the APEC member economies. It was created to foster transparency, communication, and collaboration in emerging infectious diseases among health professionals, international business and commerce leaders, and policy makers in the Asia-Pacific region.
In this edition:
- Global: Cumulative number of human cases of avian influenza A/(H5N1)
- China (Shandong): Continuous monitoring of avian influenza in wild birds
- Indonesia: 2 new cases of avian influenza H5N1 infection
- USA/Mexico: Pledge increased cooperation in pandemic influenza preparedness
- Egypt (Luxor): Report of new avian influenza H5N1 infection in poultry
- Avian/Pandemic influenza updates
- Seasonal Influenza
- CDC launches late-season flu vaccination push
- Compliance with the recommendations for two doses of trivalent inactivated influenza vaccine in children less than 9 years of age receiving influenza vaccine for the first time: a Vaccine Safety Datalink study
- Study: Flu vaccine slightly raises Guillain-Barré risk
- Tamiflu may pose risk of mental side effects
- 'Gene chip' test could speed H5N1 diagnosis
- Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors
- Third International Bird Flu Summit
- USA: Pandemic planning update III
- USA: OSHA updates guidance on avian flu
Global: Cumulative number of human cases of avian influenza A/(H5N1)
Economy / Cases (Deaths)
Total no. of confirmed human cases of avian influenza A/(H5N1), Dec 2003 to present: 258 (153).
Avian influenza age & sex distribution data from WHO/WPRO: http://www.wpro.who.int/sites/csr/data/data_Graphs.htm.
WHO's maps showing world's areas reporting confirmed cases of H5N1 avian influenza in humans, poultry and wild birds: http://gamapserver.who.int/mapLibrary/
China (Shandong): Continuous monitoring of avian influenza in wild birds
Shandong Province, east China, has reinstated round-the-clock bird flu monitoring to prevent possible outbreaks as more and more migratory birds fly over the province on their way further south. Li Zhanpeng, head of the provincial wildlife protection center, said that all 153 monitoring stations in the province were ordered to report on a daily basis. Local people were also called on to report deaths of wild birds to the provincial wildlife protection center. Its telephone hot line number is 0531-8855-7707. Wild birds migrate through 8 routes around the world, 3 of which traverse China. Migratory birds flying from East Asia to Australia pass Shandong Province. China has reported 9 outbreaks of bird flu in poultry this year, in northwestern Xinjiang Uygur Autonomous Region, north China's Shanxi Province and Inner Mongolia, east China's Anhui Province, southwestern Guizhou and Sichuan provinces and the central province of Hunan.
Indonesia: 2 new cases of avian influenza H5N1 infection
The other new case is in a 35-year-old woman from Tangerang in Banten province, also on Java, the WHO said. Her illness began Nov 7, and she has been hospitalized at Jakarta's Sulianti Saroso hospital since Nov 10. Officials are trying to learn how she was exposed to the virus. The 2 H5N1 cases are the first reported in Indonesia since Oct 16, 2006, when WHO reported 3 fatal cases, all on Java. The 17 year old suspected avian influenza case (reported in the EINet’s 10 Nov 2006 Newsbrief) remains unresolved. Indonesia has the most deaths of any country, but Vietnam still has the most cases with 93. The huge territory of Indonesia, the extent of back yard farming and the relatively sparse budget have hampered Indonesia in fighting avian influenza.
USA/Mexico: Pledge increased cooperation in pandemic influenza preparedness
The US and Mexico announced the signing of an agreement to boost cooperation on pandemic influenza preparedness among the 6 Mexican states and 4 U.S. states that share the international boundary. HHS Assistant Secretary for Public Health Emergency Preparedness Craig Vanderwagen and the Mexican Director-General of Epidemiology of the Mexican Federal Secretariat of Health Pablo Kuri signed a joint declaration to strengthen the commitment of the 2 nations to coordinate preparedness efforts, domestic and international disease surveillance activities, and response planning in the event of an outbreak of pandemic influenza. "An influenza pandemic knows no political or geographic boundaries and responding to a potential outbreak will demand the cooperation of all nations, especially those that share common borders like México and the United States," Assistant Secretary Vanderwagen said. The agreement was finalized during the 14th meeting of the US- México Border Health Commission.
Egypt (Luxor): Report of new avian influenza H5N1 infection in poultry
The Health Ministry said that new infection of H5N1 bird flu virus among domestic fowls was discovered in Luxor, 680 km south of Cairo. Tests on domestic birds at the city's Najaa al-Abayda Lab turned up positive for the H5N1 virus. The area has been quarantined and the birds were being culled. On 30 Oct 2006, an Egyptian woman died of bird flu virus and became the country's seventh fatal human case of the disease. Egypt reported the first human bird flu case 18 Mar 2006. According to Egypt's official government's bird-flu web-site (http://birdflu.sis.gov.eg/html/flu01001.htm ): “H5N1 virus has been identified in 21 governorates since its initial introduction earlier this year, namely in Cairo, Giza, Qalyubiya, Daqahliya, Alexandria, Beni Sueif, Qena, Beheira, Menoufiya, Kafr el-Sheikh, Gharbiya, Menya, Damietta, Sharqiya, Fayyoum, Sohag, Luxor City, Ismailia, Aswan and Asiut.”
Avian/Pandemic influenza updates
- WHO: http://www.who.int/csr/disease/avian_influenza/en/index.html.
- UN FAO: http://www.fao.org/ag/againfo/subjects/en/health/diseases-cards/special_avian.html.
- OIE: http://www.oie.int/eng/en_index.htm. Basic information about the upcoming conference (20-22 Mar 2007), “Vaccination, a tool for the control of avian influenza” is available.
- US CDC: http://www.cdc.gov/flu/avian/index.htm
- The US government’s web site for pandemic/avian flu: http://www.pandemicflu.gov/.
- Health Canada: information on pandemic influenza: http://www.influenza.gc.ca/index_e.html. Information on avian influenza: http://www.hc-sc.gc.ca/dc-ma/avia/index_e.html.
- CIDRAP: http://www.cidrap.umn.edu/. Frequently updated news and journal articles.
- PAHO: http://www.paho.org/English/AD/DPC/CD/influenza.htm.
- American Veterinary Medical Association: http://www.avma.org/public_health/influenza/default.asp. Updates: USDA expands plan for low-pathogenic avian influenza.
- US Geological Survey, National Wildlife Health Center Avian Influenza Information: http://www.nwhc.usgs.gov/disease_information/avian_influenza/index.jsp. Updates on the international meeting in China; latest round of surveillance in Azerbaijan in wild birds.
(WHO; FAO, OIE; CDC; Health Canada; CIDRAP; PAHO; AVMA; USGS)
CDC launches late-season flu vaccination push
Although 77 million doses of seasonal influenza vaccine have already been delivered this fall, distribution delays have left some providers empty-handed, prompting CDC to intensify its message on the benefits of late-season vaccination. CDC announced the designation of the week after Thanksgiving as "National Influenza Vaccination Week." CDC Director Julie Gerberding said the aim is to raise awareness about seasonal flu vaccination and urge more Americans to be vaccinated in Nov, Dec, and later. CDC predicts that flu vaccine manufacturers will produce a record number of doses this year, between 110 - 115 million. Gerberding said the remaining doses will be shipped through Nov and into early Dec. She urged healthcare providers to make good use of the final deliveries of flu vaccine by scheduling extra clinics, extending clinic hours, and supporting mass vaccinations at sites such as retail stores.
L.J. Tan, director of infectious diseases for the American Medical Association (AMA), said many patients mistakenly believe that the only time to get vaccinated is before Thanksgiving. Administering the flu vaccine in Nov - Jan and beyond is consistent with federal Advisory Committee on Immunization Practices recommendations. Gerberding said that though distributors try to provide at least partial fulfillment of all vaccine orders early in the season so that all providers can begin their vaccination activities, some providers are still having trouble getting their doses. Because flu vaccine sales and distribution are handled by private companies, CDC can't control the flow of the product to customers.
Tan said that smaller providers are most likely to have been affected by distribution delays. "The biggest challenges are the chronically ill, high-risk patients that seek the vaccine from their family doctors in early October," he said. "If they can't get it, they go somewhere else. We want to encourage them to go back to their physicians." Gerberding said that despite the record number of doses this year, officials worry about supplies going unused. According to CDC tracking through Nov 4, Florida and Louisiana have local activity, and North Carolina is the only state showing regional activity. Federal health officials have recommended that toddlers aged 2 - 4 years be immunized against influenza each year, adding millions of people to the groups included in vaccination recommendations.
Compliance with the recommendations for two doses of trivalent inactivated influenza vaccine in children less than 9 years of age receiving influenza vaccine for the first time: a Vaccine Safety Datalink study
Study: Flu vaccine slightly raises Guillain-Barré risk
The researchers performed 2 analyses. In the first, they identified all hospitalizations for GBS among Ontario residents aged 18 and older from Apr 1993 - Mar 2004. Then they identified which patients received flu shots and compared their risk for hospitalization for GBS for two time intervals: 2 to 7 weeks and 20 to 43 weeks after vaccination. In a second analysis, the researchers examined the number of hospitalizations for GBS in Ontario 1991 - 2004 and compared the number of cases before and after the universal flu immunization program began in 2000.
The results of the first analysis revealed there were 1,601 hospitalizations for GBS between 1993 - 2004, 269 of which occurred within 43 weeks after the patient received a vaccine, presumably for influenza, in Oct or Nov. Patients were 1.45 times as likely to be hospitalized for GBS from 2 - 7 weeks after vaccination as they were between 20 - 43 weeks after vaccination. In the second analysis, the authors identified 2,173 hospitalizations for GBS between 1991 - 2004 and found no significant difference between hospitalization rates before and after the universal immunization program took effect. The authors say the results should be interpreted carefully. “The increase in relative risk we observed corresponds to a very low absolute risk for Guillain-Barré syndrome, given the low baseline incidence of the disease (approximately 1 in 100,000 population),” they write. “Furthermore, the lack of association on a population level is consistent with the assumption that the influenza vaccine is one of many potential causes of GBS." They also note that the US Institute of Medicine in 2003 reviewed studies from the preceding 26 years and concluded there was inadequate evidence to either confirm or reject a link between flu immunization and GBS.
A recent study of the safety of the influenza vaccine in thousands of children aged 6 to 23 months found only 2 instances of GBS, and neither of the patients was diagnosed with the condition within a few weeks after vaccination. However, the researchers say that people who receive flu shots should be advised of the possible risk for GBS and that active surveillance should be included in any mass vaccination program for pandemic flu. Julie Gerberding, director of the US CDC, said the study is consistent with other research findings that have shown people who get the flu vaccine have a negligible risk of developing GBS. She said the study has not prompted the CDC to change its recommendations about flu vaccination, and added that the health risks related to flu far outweigh any risk of developing GBS from the vaccine.
Reference: Juurlink DN, Stukel TA, Kwong J, et al. Guillain-Barré syndrome after influenza vaccination in adults: a population-based study. Arch Intern Med 2006;166(20):2217-21. To read the abstract, go to:
Tamiflu may pose risk of mental side effects
The warning follows an FDA review of 103 reports of neuropsychiatric adverse events associated with oseltamivir use between Aug 29, 2005, and Jul 6, 2006, of which 95 came from Japan. That compares with 126 such adverse events reported between 1999 and Aug 2005. About two thirds of the problems were in children and youth younger than 17 years. The adverse events included 3 fatal falls. Most of the events (60/103) were described as delirium with disturbed behavior. Other problems included suicidal events, panic attacks, delusions, convulsions, depressed consciousness, and loss of consciousness.
FDA and Roche both say the contribution of the drug to the adverse events is not known. FDA says influenza by itself can lead to neuropsychiatric disorders, but many of the problems reported (e.g. suicide attempts), were not typical of those associated with flu alone. Citing factors that seem to implicate oseltamivir in the events, FDA said most of the problems occurred within a day after the start of treatment, and in many cases the physician suspected the drug was the cause. In addition, many of the patients recovered quickly after they stopped taking oseltamivir. "It is still unclear whether these neuropsychiatric events are drug-related only, disease manifestations alone, or a combination" of the two, the report states.
The analysis notes that oseltamivir is used much more widely in Japan, with 24.5 million prescriptions from 2001 - 2005, than in the US, with 6.5 million prescriptions in the same period. In Japan the product information already includes a warning about possible psychoneurological problems. The FDA report expresses concern that if oseltamivir use in the US increases to the levels seen in Japan, the number of adverse events will increase as well. "Therefore, it would be prudent to update the U.S. labeling to be similar in scope with the current Japanese labeling," it says. The Japanese origin of most of the adverse event reports might suggest that the problems are related to genetic characteristics common in Japan. But given the much greater use of the drug in Japan and the possibility of different surveillance practices there, the lack of cases reported in the US doesn't constitute good evidence for that hypothesis, it states.
'Gene chip' test could speed H5N1 diagnosis
Researchers examined the test's ability to identify 24 H5N1 viral isolates and distinguish them from 7 non-H5N1 isolates. They found that the "MChip" provided complete information about virus type and subtype for 21 of 24 H5N1 isolates and gave no false-positives, according to the National Institute of Allergy and Infectious Diseases (NIAID), which funded the research. The samples were collected from 2003-2006 from people and animals in places as widely separated as Vietnam, Nigeria, Indonesia, and Kazakhstan. 6 of the human isolates were taken from an Indonesian family in which human-to-human transmission was suspected. Analysis of 47 samples consisting of influenza A viruses (subtypes H5N1, H3N2, and H1N1) and negative controls revealed the test's sensitivity was 97% and its specificity was 100%.
Nancy J. Cox, director of the CDC's influenza division and a coauthor of the report, said, "The MChip could enable more scientists and physicians, possibly even those working in remote places, to more quickly test for H5N1 and to accurately identify the specific strain and its features." Kathy L. Rowlen, who led the research team, said that the MChip is an improvement over its predecessor, the FluChip. The latter uses 3 influenza genes—hemagglutinin (HA), neuraminidase (NA), and matrix (M)—whereas the MChip uses only the M gene. Rowlen said HA and NA are difficult to use in flu diagnostic tests because they mutate constantly. "The M segment is much less of a moving target than the HA and NA gene. . ." she said.
Rowlen said that a private company is negotiating with the University of Colorado to manufacture the test for commercial use. If approved by the Food and Drug Administration, the MChip system could be in great demand in a flu pandemic. Rowlen said foreign supply-chain disruptions in the event of a pandemic would probably not seriously affect MChip production. She said most of the raw materials used to make the test, such as glass slides and reagents, are supplied by US companies. The cost of the raw materials is about $10.
Article reference: Dawson E, Moore CL, Dankbar DM, et al. Identification of A/H5N1 influenza viruses using a single gene diagnostic microarray. Anal Chem 2006 Dec 15, in press.
Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors
The significance of this paper is that 2 independent mutations in the HA protein of avian influenza A(H5N1) virus, conferring recognition of human cell receptors, are located in the crystal structure of the HA molecule compatible with their inferred effect on receptor binding. Not all H5N1 viruses isolated from human patients, however, exhibited these mutations and other factors are likely to be involved in the host range phenotype and pandemic potential of avian influenza viruses. Yoshihiro Kawaoka, one of the authors, warned, "It is very important that we shouldn't only focus on these 2. The virus can become human-like by many mutations, these 2 are important but they are not the only ones," he said. "But these 2 will give indication when a virus has changed receptor specificity."
Third International Bird Flu Summit
The Third International Bird Flu Summit will take place in Geneva, Switzerland, 14-15 November 2006. The purpose of the summit is to prepare the World to fight this potentially infectious disease. WHO, FAO, Institut Pasteur, European Food Safety Authority, and GermFree officials will speak at the Summit. For more information, visit: http://www.new-fields.com/birdflu3/index.asp.
(Bird Flu firstname.lastname@example.org )
USA: Pandemic planning update III
USA: OSHA updates guidance on avian flu