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EINet Alert ~ Feb 27, 2009
*****A free service of the APEC Emerging Infections Network*****
APEC EINet News Briefs offers the latest news, journal articles, and notifications for emerging infections affecting the APEC member economies. It was created to foster transparency, communication, and collaboration in emerging infectious diseases among health professionals, international business and commerce leaders, and policy makers in the Asia-Pacific region.
In this edition:
1. Influenza News
- Cumulative number of human cases of avian influenza A/(H5N1)
- Global: Researchers find antibody that fights avian influenza H5N1 and seasonal influenza strains
- Global: Pandemic vaccine–making capacity rising, but still inadequate
- Austria: Vaccine manufacturer distributes material contaminated with avian influenza H5N1
- UK: Low pathogenic avian influenza detected on two poultry farms
- India (Manipur): Study finds avian influenza virus in 2007 was unique
- Indonesia: Two Tangerang residents test negative for avian influenza H5N1
- Indonesia (Bali): Officials detect second avian influenza H5N1 flare-up in 10 days
- Nepal: New avian influenza H5N1 scare in eastern region
- Singapore: Announces plan to buy 2.6m doses of avian influenza H5N1 vaccine
- Viet Nam: Previously reported avian influenza H5N1 case dies
- USA: Pediatric deaths parallel rise in influenza cases
- AVIAN/PANDEMIC INFLUENZA
- Human case of swine influenza A (H1N1), Aragon, Spain, November 2008
- Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses
- Characterization of Avian Influenza Viruses A (H5N1) from Wild Birds, Hong Kong, 2004–2008
- Capacity of Thailand to Contain an Emerging Influenza Pandemic
- Introduction into Nigeria of a Distinct Genotype of Avian Influenza Virus (H5N1)
- Stockpiling Drugs for an Avian Influenza Outbreak: Examining the Surge in Oseltamivir Prescriptions During Heightened Media Coverage of the Potential for a Worldwide Pandemic
- Adjuvanted H5N1 vaccine induces early CD4+ T cell response that predicts long-term persistence of protective antibody levels
- Association Between Serum 25-Hydroxyvitamin D Level and Upper Respiratory Tract Infection in the Third National Health and Nutrition Examination Survey
- APEC Health Working Group meeting held in Singapore
- Weekly Epidemiological Bulletin available online
1. Influenza News
Cumulative number of human cases of avian influenza A/(H5N1)
Economy / Cases (Deaths)
***For data on human cases of avian influenza prior to 2009, go to:
Total no. of confirmed human cases of avian influenza A/(H5N1), Dec 2003 to present: 408 (256).
Avian influenza age distribution data from WHO/WPRO:
WHO's maps showing world's areas affected by H5N1 avian influenza (last updated 2/23/09): http://gamapserver.who.int/mapLibrary/
WHO’s timeline of important H5N1-related events (last updated 2/23/09):
Global: Researchers find antibody that fights avian influenza H5N1 and seasonal influenza strains
Monoclonal antibodies—highly specific infection-fighting proteins derived from the same cell lineage—are being used to treat some cancers and immunologic diseases. Physicians sometimes used a basic form of the therapy during the "Spanish flu" pandemic of 1918-19, by administering blood products from recovering patients to sick patients. Antibody treatment, also called passive immunotherapy, has been used to prevent infectious diseases such as hepatitis A and B and respiratory syncytial virus infections.
Billions of antibodies scanned
At the same time, the Dana-Farber group worked with researchers at Burnham to visualize the x-ray crystal structure of an mAb that was bound to the H5N1 hemagglutinin. The image shows one arm of the mAb inserted into a genetically stable pocket in the neck of the hemagglutanin protein, which blocks the structural change needed to allow the virus to enter host cells.
Wayne Marasco, MD, PhD, associate professor of medicine at Dana-Farber, said in the press release that humans rarely make antibodies to the highly conserved region in the neck of the hemagglutinin protein. "We believe this is because the head of the hemagglutinin protein acts as a decoy by constantly undergoing mutation and thereby attracting the immune system to producing antibodies against it, rather than against the pocket in the neck of the protein," he said.
The conserved region in the neck—rather than the constantly mutating head—of the protein could provide a useful and stable new target for vaccine developers, Marasco said, adding, "An important goal is to redirect the immune response of vaccines to this invariable region of the hemagglutinin to try to obtain durable lifelong immunity."
The new strategy would offer an advantage over current seasonal flu vaccines, which are sometimes ineffective because they don't match circulating flu strains. Though vaccines developed against the H5N1 vaccine have been promising, none have elicited a broad response in humans to different H5N1 subtypes.
For seasonal influenza, treatments using mAbs could be used for those who have immune-system impairments, the NIAID said. In a pandemic setting, this group and others at risk, such as first responders, healthcare workers, and those exposed to the virus, could also benefit from mAb prophylaxis or treatment. Therapeutic mAbs are more costly to produce than other influenza drugs, but they can be readily manufactured and stockpiled, according to Dana-Farber. In a pandemic, mAbs treatment could be used with antivirals until a vaccine specific to the circulating strain becomes available.
The antibodies could be frozen and have a fairly long shelf life, Anthony Fauci, director of the NIAID, said. He added that mAb therapy typically provides potent protection for the first few weeks but wanes over the next few months.
Implications for vaccine development
"The holy grail of vaccine research is finding some part of the flu virus code that is conserved among different strains," he said, adding that if the protein the researchers found is successful in future trials, the method could be used to provide long-lasting immunity against a host of strains. As a result, scientists wouldn't need to develop a new vaccine every year, and people might need only periodic boosters, as in tetanus immunization, Schaffner said, adding that the prospect of saving money and having a healthier population is very exciting.
Global: Pandemic vaccine–making capacity rising, but still inadequate
"Pandemic vaccine production capacity has increased by 300 percent over the last two years, largely driven by improvements in production yields and dosage-sparing technologies," Oliver Wyman and the IFPMA stated. The company did not release the full report. If a pandemic emerged this year, the most likely case is that manufacturers could produce 2.5 billion doses in the first 12 months after they received the production strain, the firm said. It would take four years to produce enough to meet total global demand, meaning two doses for each of the world's 6.7 billion people. In the best case, the industry could produce 7.7 billion doses in the first 12 months of a pandemic and could meet global demand in 1½ years, the firm said.
The company predicts that annual pandemic vaccine production capacity will rise to somewhere between five billion and 14.5 billion doses over the next five years. That means the time needed to meet global demand could drop to 2½ years in the most likely case or one year in the best case.
The firm also expects that surplus vaccine production capacity—above and beyond the demand for seasonal flu vaccine and prepandemic vaccine stockpiling—will increase over the next 5 years, to between 2.6 billion and 5.4 billion annual doses. How much the capacity actually rises is likely to depend on the demand for both seasonal and prepandemic vaccines, officials said.
"I think this is a mixed story," Adam Sabow, the Wyman partner who led the preparation of the report, said. "This is good if there's new seasonal [flu vaccine] demand or if there's demand for H5N1 vaccine during the interpandemic period for efforts such as stockpiling. "However, if there isn't demand, there's a possibility that some of that capacity could be rationalized. By that we mean that capacity may either be shut down or may be redeployed for other purposes," which would reduce the ability to respond quickly to a pandemic.
He noted that there is some demand for H5N1 prepandemic vaccines, as some countries are stockpiling them, while the WHO is working on designing a global H5N1 vaccine stockpile. He said his firm is working with the WHO on that project.
Agreement on numbers
The report estimates that once a pandemic is recognized, it will take four months to develop, produce, and begin distributing a specific vaccine for it. Sabow said the estimate assumes the use of conventional egg-based production.
Egg-based and cell-based production
One of the uncertainties is what will happen to egg-base production capacity as cell-based capacity comes on line, particularly if demand for seasonal and prepandemic vaccines is lacking. "If there isn't demand, some of that egg-based capacity may be rationalized," he said.
He also said the projections related to production of prepandemic vaccine stockpiling refer to H5N1 vaccines, but the estimates of production of actual pandemic vaccines do not assume that the next pandemic virus will be an H5N1 strain. "This is based on the history of producing a range of different influenza vaccine strains," he said.
Austria: Vaccine manufacturer distributes material contaminated with avian influenza H5N1
Officials are trying to determine how vaccine manufacturer Baxter International Inc. made "experimental virus material" based on a human flu strain that was contaminated with the H5N1 avian flu virus and then distributed to an Austrian company. That company, Avir Green Hills Biotechnology, then disseminated the supposed H3N2 virus product to subcontractors in the Czech Republic, Slovenia and Germany. Authorities in the four European countries are looking into the incident, and their efforts are being closely watched by the World Health Organization and the European Centre for Disease Control (ECDC).
Though it appears none of the 36 or 37 people who were exposed to the contaminated product became infected, the incident is being described as "a serious error" on the part of Baxter, which is on the brink of securing a European license for an H5N1 vaccine. That vaccine is made at a different facility, in the Czech Republic. Dr. Angus Nicoll of the ECDC said officials still aren't 100 percent sure the mixture contained live H5N1 viruses. But given that ferrets exposed to the mixture died, it likely did.
UK: Low pathogenic avian influenza detected on two poultry farms
India (Manipur): Study finds avian influenza virus in 2007 was unique
A study of the H5N1 virus causing the outbreak of highly pathogenic avian influenza (HPAI) in Manipur in 2007 suggests that the virus originated in Russia, China, or Mongolia, and may have been brought by migrating wild birds.
A focal H5N1 outbreak in poultry was reported from Manipur, a north eastern state of India, in 2007. The aim of the study was to genetically characterize the Manipur virus isolate to understand the relationship with other H5N1 isolates and to trace the possible source of introduction of the virus into the country.
Characterization of the complete genome revealed that the virus belonged to clade 2.2. It was distinctly different from viruses of the 3 EMA sub-lineages of clade 2.2 but related to isolates from wild migratory waterfowl from Russia, China, and Mongolia. A stop codon at position 29 in the PB1-F2 protein could have implications on the replication efficiency. The acquisition of polymorphisms as seen in recent isolates of 2005-07 from distinct geographical regions suggests the possibility of transportation of H5N1 viruses through migratory birds.
The authors concluded that considering that all eight genes of the earlier Indian isolates belonged to the EMA3 sub-lineage and similar strains have not been reported from neighboring countries of the sub-continent, it appears that the virus may have been introduced independently.
Indonesia: Two Tangerang residents test negative for avian influenza H5N1
A 15-year-old boy and a 2-year-old child were being treated in the bird flu isolation unit at Tangerang General Hospital for almost a week. The pair was admitted to the unit when the hospital found they had high fever and difficulty breathing, and local authorities reported that there was dead poultry near their places of residence. Yully said the symptoms found were indicative of acute respiratory infection disease and bronchitis.
Indonesia (Bali): Officials detect second avian influenza H5N1 flare-up in 10 days
"We immediately conducted a rapid test and found that the chickens were infected with the H5N1 virus," Sandjada said. Following the discovery, Sandjaja said the agency banned the transportation of poultry in and out of the village and had been culling the bird population and disinfecting cages since 19 Feb 2009. He said the agency was still concerned because a number of birds from Banyubiru had been sold to neighboring villages.
To head off further spread of the virus, the agency also conducted disinfecting drives in the nearby Gilimanuk market and chicken slaughterhouses. Dozens of chickens had died recently in the Arum Gilimanuk area.
Bird flu first emerged on the island in Jembrana district in 2007-08, causing the deaths of hundreds of chickens and infecting some local residents. One person died from the virus.
Sandjaja said the local government was concerned because the latest outbreak was the second to strike in less than 10 days. Earlier in February 2009, a bird flu outbreak emerged in Badung district, causing 133 chickens to be destroyed. One person suffered bird-flu-like symptoms after contact with sick poultry but later recovered. The Ministry of Health only releases information about suspected cases a few times a year, and test results from that particular case have not yet been released.
Nepal: New avian influenza H5N1 scare in eastern region
"Bird flu has been detected in Sharanmati village in Jhapa district," said Hari Dahal, spokesman at Nepal's Agriculture and Cooperatives Ministry. The village lies close to Nepal's border with India's West Bengal state, about 40 km southwest of the border town of Kakarbhitta, where the first outbreak was reported in mid-January 2009.
From 20-22 Feb 2009, 150 chickens died in Sharanmati, Dahal said, causing the government to bring samples to Kathmandu for examination. After the tests confirmed the presence of the H5N1 virus, the samples were sent to London's Weybridge Laboratory for further tests. "They have just informed us that all the seven samples tested positive," Dahal said.
The government is sending a rapid action team to the village and setting up a control room. It is going to sound a high alert and declare emergency operations in and around the village. The culling of poultry will start fresh in the bird flu-hit tea district and surveillance on the border entries with India tightened.
Dahal expressed fears that the ailing birds could have been smuggled from India for sale in Nepal. "India has bird flu outbreak in West Bengal, Sikkim and Assam states," he said. "The birds are likely to have been brought from there. They were hidden in a backyard." Dahal said that Kakarbhitta, where the first outbreak was reported, leading to the destruction of nearly 25 000 chickens and poultry products, had not reported fresh signs of the disease. The disease has not been reported in humans in Nepal.
Singapore: Announces plan to buy 2.6m doses of avian influenza H5N1 vaccine
The original defense against a bird flu pandemic was to give the more than 50,000 'essential' people, such as doctors and policemen, six weeks' supply of Tamiflu, an antiviral drug that reduces the effects of the illness by preventing the bug from multiplying. But there has been growing resistance to the drug recently, which could mean it might be less effective in the event of a bird flu pandemic. This past winter, the northern hemisphere has thrown up a 15 percent resistance to the medicine in another flu strain - the H1N1 - up from 1 percent the previous winter.
The vaccine Singapore will be spending tens of millions of dollars to buy is targeted at the H5N1 or bird flu virus. It is not effective against other strains of flu. So if the next pandemic is not the H5N1, the vaccines would be useless.
This is why Singapore is also increasing its stockpile of Tamiflu, an antiviral drug that works for all flu strains. By the end of this year, Singapore will have 1.7 million courses, up from the original 1.05 million courses. Each course consists of 10 capsules which are taken over five days. It also has 50,000 courses of Relenza, another antiviral.
The United States has stockpiled about 26 million doses of the H5N1 vaccine. Countries like Switzerland and Ireland have enough for their entire population. Singapore expects to get its 2.6 million doses within six months.
For the vaccine to be effective, people need to get two doses three weeks apart. The plan is to start vaccinating the moment the World Health Organisation declares an increase in human-to-human transmission. For the moment, these transmissions remain rare.
Viet Nam: Previously reported avian influenza H5N1 case dies
So far in 2009, nine provinces of Viet Nam nationwide have been hit by avian flu, including four provinces in the Mekong Delta, namely Ca Mau, Soc Trang, Hau Giang, and Bac Lieu, two northern provinces of Bac Ninh and Quang Ninh, two central provinces of Nghe An and Quang Tri, and the newly confirmed southern Khanh Hoa, said the Department of Animal Health of the Vietnamese Ministry of Agriculture and Rural Development.
Viet Nam has reported three human cases of bird flu so far in 2009. An eight-year-old girl from northern Thanh Hoa province in early January 2009 has recovered, a newly-confirmed man who is still being treated, and the first and recently deceased 23-year-old woman from northern Quang Ninh province.
In 2008, bird flu killed 5 people in Viet Nam.
USA: Pediatric deaths parallel rise in influenza cases
The US Centers for Disease Control and Prevention (CDC) reported on 20 Feb 2009 a spike in the number of pediatric influenza deaths, an increase that mirrors a continuing rise in flu activity across the nation. The CDC said it received six reports of influenza-related flu deaths in children during the week ending 14 Feb 2009, though one occurred during the 2006-07 flu season. The remaining five deaths raise the number of pediatric flu deaths during the 2008-09 season to nine.
Bacterial coinfections were confirmed in six of the nine children; four involved Staphylococcus aureus, two of which were methicillin resistant. All of the children who had coinfections were age 5 or older. Meanwhile, other states reported more new pediatric flu deaths, which will likely be included in upcoming CDC weekly influenza updates.
Colorado's Department of Public Health and Environment (CDPHE) announced on 19 Feb 2009 that four Colorado children have died from influenza-related complications in 2009. The first occurred in mid-January, and the last was reported on 18 Feb 2009. The CDPHE said the state's number of pediatric flu deaths has already topped the past four flu seasons, which averaged two fatalities per year.
Three of the children were toddlers, and one was an infant. Two of the children had received partial vaccines (one of two recommended doses), and the other two were unvaccinated. At least two of the children had serious underlying medical conditions, the CDPHE said.
Ken Gershman, chief of the CDPHE's communicable disease program, said that child flu deaths are tragic, because the disease is often preventable. Last year the CDC expanded its flu vaccination recommendation to include all children from ages 5 through 18. It had already recommended flu immunizations for younger children between the ages of 6 and 59 months.
Over the past few days other states have reported more pediatric flu deaths, including:
Nationally, the number of states reporting widespread flu activity rose to 24, eight more than the previous surveillance week that ended on 7 Feb 2009, the CDC reported. Most of the hardest-hit states are in the eastern part of the country, except for Texas, Colorado, and Nevada. Thirteen additional states reported regional influenza activity.
Nearly all (98.5%) influenza A/H1N1 samples that have been tested showed resistance to oseltamivir (Tamiflu). Of viruses that have been antigenically characterized, all influenza A/H1N1 and influenza A/H3N2 viruses matched the vaccine components. However, only about a third of the influenza B viruses match the Yamagata lineage that is included in this year's vaccine—the rest were from the Victoria lineage.
- UN: http://www.undp.org/mdtf/influenza/overview.shtml UNDP’s web site for information on fund management and administrative services and includes the website of the Central Fund for Influenza Action. This site also includes a list of useful links.
- WHO: http://www.who.int/csr/disease/avian_influenza/en/index.html The (interim) Influenza Virus Tracking System can be accessed at: www.who.int/fluvirus_tracker.
- UN FAO: http://www.fao.org/avianflu/en/index.html. View the latest avian influenza outbreak maps, upcoming events, and key documents on avian influenza.
- OIE: http://www.oie.int/eng/info_ev/en_AI_avianinfluenza.htm. Link to the Communication Portal gives latest facts, updates, timeline, and more.
Epidemiological updates on the avian influenza outbreak in Hong Kong available at http://www.oie.int/wahis/public.php?page=single_report&pop=1&reportid=7609 and the outbreak in India at http://www.oie.int/wahis/public.php?page=single_report&pop=1&reportid=7606.
- US CDC: Visit "Pandemic Influenza Preparedness Tools for Professionals" at: http://www.cdc.gov/flu/pandemic/preparednesstools.htm. This site contains resources to help hospital administrators and state and local health officials prepare for the next influenza pandemic.
- The US government’s website for pandemic/avian flu: http://www.pandemicflu.gov/. View archived Webcasts on influenza pandemic planning.
- CIDRAP: http://www.cidrap.umn.edu/ Find more than 150 peer-reviewed practices from 25 US states and 37 cities and counties aimed at furthering pandemic preparedness in public health and allied fields.
- PAHO: http://www.paho.org/English/AD/DPC/CD/influenza.htm Link to the Avian Influenza Portal at: http://influenza.bvsalud.org/php/index.php?lang=en. The Virtual Health Library’s Portal is a developing project for the operation of product networks and information services related to avian influenza.
- US National Wildlife Health Center: http://www.nwhc.usgs.gov/disease_information/avian_influenza/index.jsp. Read about the latest news on H5N1 in wild birds and poultry.
(UN; WHO; FAO, OIE; CDC; CIDRAP; PAHO; USGS)
Human case of swine influenza A (H1N1), Aragon, Spain, November 2008
Sancho BA et al. Eurosurveillance. 19 Feb 2009; 14(7). Available at http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19120.
A human case of swine influenza A (H1N1) in a 50-year-old woman from a village near Teruel (Aragón, in the north-east of Spain), with a population of about 200 inhabitants, has been reported in November 2008.
On 8 November 2008, a 50-year old woman developed fever, cough, extreme tiredness, myalgia, irritation of the nasal/oral mucosae and shivers of sudden onset. During a medical visit on 12 November 2008, the general practitioner (GP) who treated the case and is a member of the sentinel influenza surveillance system, took a throat swab sample and sent it to the Microbiology Laboratory of the Miguel Servet University Hospital in Zaragoza, Aragón in the context of the Spanish Influenza Surveillance System. The patient, with no history of recent travel, did not need specific treatment or hospitalisation and recovered fully.
Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses
Influenza virus remains a serious health threat, owing to its ability to evade immune surveillance through rapid genetic drift and reassortment. Here we used a human non-immune antibody phage-display library and the H5 hemagglutinin ectodomain to select ten neutralizing antibodies (nAbs) that were effective against all group 1 influenza viruses tested, including H5N1 'bird flu' and the H1N1 'Spanish flu'. The crystal structure of one such nAb bound to H5 shows that it blocks infection by inserting its heavy chain into a conserved pocket in the stem region, thus preventing membrane fusion. Nine of the nAbs employ the germline gene VH1-69, and all seem to use the same neutralizing mechanism. Our data further suggest that this region is recalcitrant to neutralization escape and that nAb-based immunotherapy is a promising strategy for broad-spectrum protection against seasonal and pandemic influenza viruses.
Characterization of Avian Influenza Viruses A (H5N1) from Wild Birds, Hong Kong, 2004–2008
Capacity of Thailand to Contain an Emerging Influenza Pandemic
Introduction into Nigeria of a Distinct Genotype of Avian Influenza Virus (H5N1)
Stockpiling Drugs for an Avian Influenza Outbreak: Examining the Surge in Oseltamivir Prescriptions During Heightened Media Coverage of the Potential for a Worldwide Pandemic
Objective. During fall 2005, personal stockpiling of oseltamivir for use during an outbreak of H5N1 influenza virus infection was widely reported. The present study aimed to identify indications for oseltamivir prescriptions to determine whether oseltamivir that was not intended for seasonal influenza was inappropriately consumed and to compare persons who were likely to have stockpiled oseltamivir and those who did not with respect to their knowledge, understanding, concerns, and expectations regarding avian influenza.
Design. Survey to evaluate usage patterns for oseltamivir and assess views about avian influenza.
Subjects. A total of 109 outpatients who received a prescription for oseltamivir between September 1, 2005, and December 31, 2005, and 825 matched control subjects.
Results. Of 109 prescriptions, 36 (33.0%) were prescribed for patients with appropriate indications. Sixty-eight (62.4%) of 109 patients identified as having received oseltamivir and 440 (53.3%) of 825 individuals identified as not having received it responded to the questionnaire. Only 2 prescription recipients whose oseltamivir was not intended for immediate consumption reported that they had consumed the oseltamivir. Persons who probably intended to stockpile oseltamivir were older and more often white than those unlikely to stockpile it. They also reported greater worry about avian influenza and more often expected avian influenza to spread to the United States than those unlikely to stockpile, but there were no significant differences in responses to other questionnaire items.
Conclusions. A large proportion of the oseltamivir prescriptions written in fall 2005 were probably intended for personal stockpiling. Similarities in participants' responses to questionnaire items suggest that educational campaigns may not be an effective method to curtail stockpiling of antimicrobial medications during an infectious threat. Promoting appropriate prescribing practices among providers may be a better means by which to minimize personal stockpiling.
Adjuvanted H5N1 vaccine induces early CD4+ T cell response that predicts long-term persistence of protective antibody levels
Association Between Serum 25-Hydroxyvitamin D Level and Upper Respiratory Tract Infection in the Third National Health and Nutrition Examination Survey
Background. Recent studies suggest a role for vitamin D in innate immunity, including the prevention of respiratory tract infections (RTIs). We hypothesize that serum 25-hydroxyvitamin D (25[OH]D) levels are inversely associated with self-reported recent upper RTI (URTI).
Methods. We performed a secondary analysis of the Third National Health and Nutrition Examination Survey, a probability survey of the US population conducted between 1988 and 1994. We examined the association between 25(OH)D level and recent URTI in 18 883 participants 12 years and older. The analysis adjusted for demographics and clinical factors (season, body mass index, smoking history, asthma, and chronic obstructive pulmonary disease).
Results. The median serum 25(OH)D level was 29 ng/mL (to convert to nanomoles per liter, multiply by 2.496) (interquartile range, 21-37 ng/mL), and 19% (95% confidence interval [CI], 18%-20%) of participants reported a recent URTI. Recent URTI was reported by 24% of participants with 25(OH)D levels less than 10 ng/mL, by 20% with levels of 10 to less than 30 ng/mL, and by 17% with levels of 30 ng/mL or more (P < .001). Even after adjusting for demographic and clinical characteristics, lower 25(OH)D levels were independently associated with recent URTI (compared with 25[OH]D levels of 30 ng/mL: odds ratio [OR], 1.36; 95% CI, 1.01-1.84 for <10 ng/mL and 1.24; 1.07-1.43 for 10 to <30 ng/mL). The association between 25(OH)D level and URTI seemed to be stronger in individuals with asthma and chronic obstructive pulmonary disease (OR, 5.67 and 2.26, respectively).
Conclusions. Serum 25(OH)D levels are inversely associated with recent URTI. This association may be stronger in those with respiratory tract diseases. Randomized controlled trials are warranted to explore the effects of vitamin D supplementation on RTI.
APEC Health Working Group meeting held in Singapore
The first meeting of the APEC Health Working Group 2009 successfully convened in Singapore 19-20 Feb 2009 to address pandemic influenza vaccine stockpiling capacity, regional preparedness collaboration, among other timely topics. APEC EINet was represented by Dr. Ann Marie Kimball, who discussed future work in the area of preparedness and videoconferencing. A summary update of the meeting be included in the near future.
Weekly Epidemiological Bulletin available online
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