OUR FACULTY

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Profiles

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Research Areas

Areas of faculty research include:

mechanisms of chemical carcinogenesis and anticarcinogenesis
behavioral and molecular neurological effects of toxic chemicals
mechanism of toxicity of solvents and metals
mechanisms of chemically induced birth defects
molecular regulation of detoxification enzymes
effects of toxic
trace metals on organ development and function
physiological and morphological studies of the effects of air pollutants on the lung and heart

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Research Publications

Selected Publications July 2003 – June 2007

This list includes books, book chapters, articles, and reviews in professional journals. It excludes letters, technical reports, or conference presentations.

Abel EL, Opp SM, Verlind CL, Bammler TK, Eaton DL. Characterization of atrazine biotransformation by human and murine Glutathione S-Transferases. Toxicol Sciences 2004; 80:30-238.

Balduini W, Cattabeni F, Costa LG, Tita B (eds.). Tossicologia. Italian Edition of Casarett and Doull’s Toxicology. The Basic Science of Poisons (CD Klaassen, ed.). EMSI, Roma 2006 (in press).

Bartell SM, Griffith WC, Faustman EM. Temporal error of biomarker-based mean exposure estimates for individuals. J Exp Anal Envir Epid 2004; 14 (2):173-179.

Bea F, Hudson FN, Kavanagh TJ, Rosenfeld MJ (2003). The induction of glutathione synthesis in macrophages by oxidized low density lipoproteins is mediated by consensus antioxidant response elements. Circ Res 92:386-93

Bekris LM, Shephard C, Peterson M, Hoehna J, Van Yserloo B, Rutledge E, Farin F, Kavanagh TJ, Lernmark A. Glutathione-s-transferase M1 and T1 polymorphisms and associations with type 1 diabetes age-at-onset. Autoimmunity. 2005 Dec; 38(8):567-575.

Bekris LM, Kavanagh TJ, Lernmark A. Targeting type 1 diabetes before and at the clinical onset of disease. Endocr Metab Immune Disord Drug Targets. 2006 Mar; 6(1):103-24.

Bekris LM, Viernes HM, Farin FM, Maier LA, Kavanagh TJ, Takaro TK. Chronic beryllium disease and glutathione biosynthesis genes. J Occup Environ Med. 2006 Jun; 48(6):599-606.

Bernard S, Luchtel DL, Hlastala MP, Lakshminarayan S. Characterization of bronchial-to-pulmonary communications. Arch Physiol Biochem 2003;111(4): 317-318.

Botta D, Franklin CC, White CC, Krejsa CM, Dabrowski MJ, Pierce RH, Fausto N, Kavanagh TJ. Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosis. Free Rad Biol Med 2004; 37:632-42.

Botta D, Shi S, White CC, Dabrowski MJ, Keener CL, Srinouanprachanh SL, Farin FM, Ware CB, Ladiges WC, Pierce RH, Fausto N, Kavanagh TJ. Acetaminophen-induced liver injury is attenuated in male glutamate cysteine ligase transgenic mice. J Biol Chem. 2006; 281(39):28865-28875.

Burbacher T, Shen D, Lalovic B, Grant K, Sheppard L, Damian D, Ellis S, Liberato N. Chronic maternal methanol inhalation in nonhuman primates (Macaca fascicularis): Exposure and toxicokinetics prior to and during pregnancy. Neurotoxicol Teratol 2004; 26:201-221.

Burbacher T, Grant K, Shen D, Sheppard L, Damian D, Ellis S, Liberato N. Chronic maternal methanol inhalation in nonhuman primates (Macaca fascicularis): Reproductive performance and newborn outcome. Neurotoxicol Teratol 2004; 26:639-650.

Burbacher TM, Grant KS, Mayfield DB, Gilbert SG, Rice DC. Prenatal methylmercury exposure affects spatial vision in adult monkeys. Toxicol Appl Pharmacol. 2005 Oct 1; 208(1):21-28.

Burbacher TM, Shen DD, Liberato N, Grant KS, Cernichiari E, Clarkson T. Comparison of blood and brain mercury levels in infant monkeys exposed to methylmercury or vaccines containing thimerosal. Environ Health Perspect. 2005 Aug; 113(8):1015-1021.

Burbacher T, Grant K, Mayfield D, Gilbert S, Rice D. Prenatal methylmercury exposure affects spatial vision in adult monkeys. Toxicology and Applied Pharmacology. 2005; 208(1):21-28.

Cai B, Chang SH, Becker EB, Bonni A, Xia Z. p38 MAP kinase mediates apoptosis through phosphorylation of BimEL at Ser-65. J Biol Chem. 2006 Sep 1; 281(35):25215-25222.

Caughlan A, Newhouse K, Namgung U, Xia Z. Chlorpyrifos induces apoptosis in rat cortical neurons that is regulated by a balance between p38 and ERK/JNK MAP kinases. Toxicol Sciences 2004; 78(1):125-34.

Cole TB, Walter BJ, Shih DM, Tward AD, Lusis AJ, Timchalk C, Richter RJ, Costa LG, Furlong CE. Toxicity of chlorpyrifos and chlorpyrifos oxon in a transgenic mouse model of the human paraoxonase (PON1) Q192R polymorphism. Pharmacogenet Genomics 2005; 15(8):589-598.

Corey LM, Baker C, Luchtel DL. Heart-rate variability in the apolipoprotein E knockout transgenic mouse following exposure to Seattle particulate matter. J Toxicol Environ Health A. 2006 May; 69(10):953-965.

Costa LG. Current issues in organophosphate toxicology. Clin Chim Acta. 2006 Apr; 366(1-2):1-13.

Costa LG. Receptors and ion channels. IN: Gene-Environment Interactions: Fundamentals of Ecogenetics. LG Costa, DL Eaton eds. John Wiley & Sons, Hoboken, NJ, 2006; 197-210.

Costa LG. Toxic effects of pesticides. IN: Casarett and Doull’s Toxicology. The Basic Science of Poisons. 7th Edition. CD Klaassen ed. McGraw-Hill, New York, NY (in press)

Costa LG, Cole TB, Furlong CE. Paraoxonase (PON1): from toxicology to cardiovascular medicine. Acta Biomed Ateneo Parmense. 2005; 76 Suppl 2:50-57.

Costa LG, Cole TB, Geiss GK, Furlong CE. Paraoxonase, butyrylcholinesterase and epoxide hydrolase. IN: Gene-Environment Interactions: Fundamentals of Ecogenetics. L.G. Costa, D.L. Eaton eds. John Wiley & Sons, Hoboken, NJ, 2006; 159-177.

Costa LG, Cole TB, Vitalone A, Furlong CE. Paraoxonase polymorphisms and toxicity of organophosphates. IN: Toxicology of Organophosphate and Carbamate Pesticides. RC Gupta ed. Elsevier, Burlington, MA 2006; 247-256.

Costa LG, Eaton DL (eds.). Gene-Environment Interactions: Fundamentals of Ecogenetics. John Wiley & Sons, Hoboken, NJ, 2006.

Dabrowski MJ, Maeda D, Zebala J, Lu WD, Mahajan S, Kavanagh TJ, Atkins WM. Glutathione S-transferase P1-1 expression modulates sensitivity of human kidney 293 cells to photodynamic therapy with hypericin. Arch Biochem Biophys. 2006 May 15; 449(1-2):94-103.

Daston G, Faustman E, Ginsberg G, Fenner-Crisp P, Olin S, Sonawane B, Bruckner J, Breslin W, McLaughlin TJ. A framework for assessing risks to children from exposure to environmental agents. Environ Health Pers 2004; 112(2):238-56.

DeRouen TA, Martin MD, Leroux BG, Townes BD, Woods JS, Leitao J, Castro-Caldas A, Luis H, Bernardo M, Rosenbaum G, Martins IP. Neurobehavioral effects of dental amalgam in children: a randomized clinical trial. JAMA. 2006 Apr 19; 295(15):1784-1792.

Dieguez-Acuna FJ, Polk WW, Ellis ME, Simmonds PL, Kushleika JV, Woods JS. Nuclear factor kappaB activity determines the sensitivity of kidney epithelial cells to apoptosis: implications for mercury-induced renal failure. Toxicol Sci 2004 Nov;82(1):114-123.

Doi A, Pham R, Hughes E, Barber DS, Gallagher E. 2004. Molecular cloning and characterization of a glutathione S-transferase in largemouth bass liver that is involved in the detoxification of 4-hydroxynonenal. Biochem Pharmacol 2004; 67(11):2129-2139.

Eaton DL. Glutathione S-transferases as putative host susceptibility genes for cancer risk in agricultural workers. J Biochem Mol Toxicol. 2005; 19(3):187-189.

Echeverria D, Woods JS, Heyer NJ, Rohlman D, Farin FM, Li T, Garabedian CE. The association between a genetic polymorphism of coproporphyrinogen oxidase, dental mercury exposure and neurobehavioral response in humans. Neurotoxicol Teratol. 2006 Jan-Feb; 28(1):39-48.

Echeverria D, Woods JS, Heyer NJ, Rohlman DS, Farin FM, Bittner AC Jr, Li T, Garabedian C. Chronic low-level mercury exposure, BDNF polymorphism, and associations with cognitive and motor function. Neurotoxicol Teratol. 2005 Nov-Dec; 27(6):781-796.

Faustman E, Gohlke M, Judd N, Lewandowski T, Bartell S, Griffith W. Modeling developmental processes in animals: Applications in neurodevelopmental toxicolog. Environ Toxicol and Pharmacol 2005; 19(3):615-624.

Furlong CE, Cole TB, Jarvik GP, Pettan-Brewer C, Geiss GK, Richter RJ, Shih DM, Tward AD, Lusis AJ, Costa LG. Role of paraoxonase (PON1) status in pesticide sensitivity: genetic and temporal determinants. Neurotoxicology. 2005 Aug; 26(4):651-659. Review.

Furlong CE, Cole TB, Walter BJ, Shih DM, Tward A, Lusis AJ, Timchalk C, Richter RJ, Costa LG. Paraoxonase 1 (PON1) status and risk of insecticide exposure. J Biochem Mol Toxicol. 2005; 19(3):182-183.

Gallagher EP. Using salmonid microarrays to understand the dietary modulation of carcinogenesis in rainbow trout. Toxicol Sci. 2006 Mar; 90(1):1-4.

Gallagher EP, Gardner JL, Barber DS. Several glutathione S-transferase isozymes that protect against oxidative injury are expressed in human liver mitochondria. Biochem Pharmacol. 2006 May 28; 71(11):1619-1628.

Gharib SA, Luchtel DL, Madtes DK, Glenny RW. Global gene annotation analysis and transcriptional profiling identify key biological modules in hypoxic pulmonary hypertension. Physiol Genomics. 2005 Jun 16; 22(1):14-23.

Gardner JL, Doi AM, Pham RT, Huisden CM, Gallagher EP. Ontogenic differences in the detoxification of 4-hydroxynonenal are associated with in vitro injury to human hematopoietic progenitor cells. Toxicol Appl Pharmacol 191(2):95-106.

Giordano G, Afsharinejad Z, Guizzetti M, Vitalone A, Kavanagh TJ, Costa LG. Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency. Toxicol Appl Pharmacol. 2007; 219(2-3):181-189.

Giordano G, White CC, McConnachie LA, Fernandez C, Kavanagh TJ, Costa LG. Neurotoxicity of domoic acid in cerebellar granule neurons in a genetic model of glutathione deficiency. Mol Pharmacol 2006; 70(6):2116-26.

Giordano G, Sanchez-Perez AM, Montoliu C, Berezney R, Malyavantham K, Costa LG, Calvete JJ, Felipo V. Activation of NMDA receptors induces protein kinase A-mediated phosphorylation and degradation of matrin 3. Blocking these effects prevents NMDA-induced neuronal death. J Neurochem. 2005 Aug; 94(3):808-818.

Gohlke JM, Griffith WC, Faustman EM. The role of cell death during neocortical neurogenesis and synaptogenesis: Implications from a computational model for the rat and mouse. Dev Brain Research 2004; 151(1-2):43-54.

Guizzetti M, Bordi F, Dieguez-Acuna FJ, Vitalone A, Madia F, Woods JS, Costa LG. Nuclear factor kappaB activation by muscarinic receptors in astroglial cells: effect of ethanol. Neuroscience. 2003;120(4):941-50.

Guizzetti M, Pathak S, Giordano G, Costa LG. Effect of organophosphorus insecticides and their metabolites on astroglial cell proliferation. Toxicology. 2005 Nov 15; 215(3):182-190.

Guizzetti M, Thompson B, Kim Y, VanDeMark K, Costa LG. Role of phospholipase D signaling in ethanol-induced inhibition of carbachol-stimulated DNA synthesis of 1321N1 astrocytoma cells. J Neurochem 2004; 90(3):646-53.

Guo Y, Breeden LL, Fan W, Zhao LP, Eaton DL, Zarbl H. Analysis of cellular responses to aflatoxin B(1) in yeast expressing human cytochrome P450 1A2 using cDNA microarrays. Mutat Res. 2006 Jan 29; 593(1-2):121-142.

Guo Y, Breeden LL, Zarbl H, Preston BD, Eaton DL. Expression of a human cytochrome p450 in yeast permits analysis of pathways for response to and repair of aflatoxin-induced DNA damage. Mol Cell Biol. 2005 Jul; 25(14):5823-5833.

Henson KA, Gallagher EP. Glutathione S- transferase expression in pollution-associated hepatic lesions of brown bullheads (Ameriurus nebulosus) from the Cuyahoga River, Cleveland, Ohio. Toxicol Sciences 2004; 80(1):26-33.

Heyer NJ, Bittner AC Jr, Echeverria D, Woods JS. A cascade analysis of the interaction of mercury and coproporphyrinogen oxidase (CPOX) polymorphism on the heme biosynthetic pathway and porphyrin production. Toxicol Lett. 2006 Feb 20; 161(2):159-166.

Heyer NJ, Echeverria D, Bittner AC Jr, Farin FM, Garabedian CC, Woods JS. Chronic low-level mercury exposure, BDNF polymorphism, and associations with self-reported symptoms and mood. Toxicol Sci. 2004 Oct;81(2):354-63.

Ho HK, White CC, Fernandez C, Fausto N, Kavanagh TJ, Nelson SD, Bruschi SA. RNrf2 activation involves an oxidative-stress independent pathway in tetrafluoroethylcysteine-induced cytotoxicity. Toxicol Sci. 2005 Aug; 86(2):354-364.

Hsuan SL, Klintworth HM, Xia Z. Basic fibroblast growth factor protects against rotenone-induced dopaminergic cell death through activation of extracellular signal-regulated kinases 1/2 and phosphatidylinositol-3 kinase pathways. J Neurosci. 2006 Apr 26; 26(17):4481-4491.

Hughes EM, Gallagher EP. Effects of 4-nonylphenol and 17 Beta-estradiol on phase two antioxidant gene expression in largemouth bass liver. Comparative Biochem Physiol 2004; 137:237-247.

Hughes, EM and Gallagher EP. Effect of naphthoflavone on biotransformation gene expression and glutathione biosynthesis in largemouth bass liver. Marine Environmental Res 2004; 58:675-679

Hujoel PP, Lydon-Rochelle M, Bollen AM, Woods JS, Geurtsen W, del Aguila MA. Mercury exposure from dental filling placement during pregnancy and low birth weight risk. Am J Epidemiol. 2005 Apr 15;161(8):734-40.

Judd NL, Drew CH, Acharya C, Mitchell TA, Donatuto JL, Burns GW, Burbacher TM, Faustman EM. Marine Resources for Future Generations. Framing scientific analyses for risk management of environmental hazards by communities: case studies with seafood safety issues. Environ Health Perspect. 2005 Nov; 113(11):1502-1508.

Jansen KL, Larson TV, Koenig JQ, Mar TF, Fields C, Stewart J, Lippmann M. Associations between health effects and particulate matter and black carbon in subjects with respiratory disease. Environ Health Perspect. 2005 Dec; 113(12):1741-1746.

Judd NL, Griffith WC, Faustman EM. Consideration of cultural and lifestyle factors in defining susceptible populations for environmental disease. Toxicology. 2004; 198(1-3):121-33.

Judd NL, Griffith WC, Faustman EM. Contribution of PCB Exposure from fish consumption to total dioxin-like dietary exposure. Regul Toxicol Pharmacol 2004; 40(2)-125-135.

Judd NL, Karr JR, Griffith WC, Faustman EM. Challenges in defining background levels for human and ecological risk assessments. Hum Ecol Risk Assess 2003; (7):1623-1632.

Karr C, Lumley T, Shepherd K, Davis R, Larson T, Ritz B, Kaufman J. A case-crossover study of wintertime ambient air pollution and infant bronchiolitis. Environ Health Perspect. 2006 Feb; 114(2):277-281.

Kelada SN, Checkoway H, Costa LG. Neurodegenerative diseases. IN: Gene-Environment Interactions: Fundamentals of Ecogenetics. LG Costa, DL Eaton eds. John Wiley & Sons, Hoboken, NJ, 2006; 253-269.

Kelada SN, Checkoway H, Kardia SL, Carlson CS, Costa-Mallen P, Eaton DL, Firestone J, Powers KM, Swanson PD, Franklin GM, Longstreth WT Jr, Weller TS, Afsharinejad Z, Costa LG. 5' and 3' region variability in the dopamine transporter gene (SLC6A3), pesticide exposure and Parkinson's Disease risk: A hypothesis generating study. Hum Mol Genet. 2006; 15(20):3055-62.

Kelada SN, Costa-Mallen P, Checkoway H, Carlson CS, Smith-Weller T, Swanson PD, Franklin GM, Longstreth WT Jr., Afsharinejad Z, Costa LG. Dopamine transporter (SLC6A3) 5’ region haplotypes significantly affect transcriptional activity in vitro, but are not associated with Parkinson’s disease. Pharmacogenetics Genomics 2005;15:659-668.

Kevil CG, Pruitt H, Kavanagh TJ, Wilkerson J, Farin F, Moellering D, Darley-Usmar VM, Bullard DC, Patel RP. Regulation of endothelial glutathione by ICAM-1: implications for inflammation. FASEB J 2004; 18(11):1321-3.

Koenig JQ, Mar TF, Allen RW, Jansen K, Lumley T, Sullivan JH, Trenga CA, Larson T, Liu LJ. Pulmonary effects of indoor- and outdoor-generated particles in children with asthma. Environ Health Perspect. 2005 Apr;113(4):499-503.

Klintworth H, Newhouse K, Li T, Choi WS, Faigle R, Xia Z. Activation of c-Jun N-terminal protein kinase is a common mechanism underlying paraquat- and rotenone-induced dopaminergic cell apoptosis. Toxicol Sci. 2007 Feb 25; [Epub ahead of print]

Knoll N, Ruhe C, Veeriah S, Sauer J, Glei M, Gallagher EP, Pool-Zobel BL. Genotoxicity of 4-Hydroxy-2-Nonenal in human colon tumor cells is associated with cellular levels of glutathione and the modulation of Glutathione S-Transferase A4 expression by butyrate. Toxicol Sci 2005; 86(1):27-35

Koenig JQ, Jansen K, Mar TF, Lumley T, Kaufman J, Trenga CA, Sullivan J, Liu LJ, Shapiro GG, Larson TV. Measurement of offline exhaled nitric oxide in a study of community exposure to air pollution. Environ Health Perspect. 2003 Oct;111(13):1625-9.

Kramer CB, Cullen AC, Faustman EM. Policy implications of genetic information on regulation under the Clean Air Act: The case of particulate matter and asthmatics. Environmental Health Perspective 2006 Mar; 114 (3): 313-319.

Krzywanski DM, Dickinson DA, Iles KE, Wigley AF, Franklin CC, Liu RM, Kavanagh TJ, Forman HJ. Variable regulation of glutamate cysteine ligase subunit proteins affects glutathione biosynthesis in response to oxidative stress. Arch Biochem Biophys 2004; 423(1):116-25.

Lewandowski TA, Ponce RA, Charleston JS, Hong S, Faustman EM. Effect of methylmercury on midbrain cell proliferation during organogenesis: Potential cross-species differences and implications for risk assessment. Toxicol Sciences 2003; 75,124-133.

Liu L, Cavanaugh JE, Wang Y, Sakagami H, Mao Z, Xia Z. ERK5 activation of MEF2-mediated gene expression pays a critical role in BDNF-promoted survival of developing but not mature cortical neurons. Proc Natl Acad Sci USA 2003; 100(14): 8532-8537.

Luderer U, Bushley A, Stover BD, Bremner WJ, Faustman EM, Takaro TK, Checkoway H, Brodkin CA. Effects of occupational solvent exposure on reproductive hormone concentrations and fecundability in men. Am J Ind Med 2004; 46(6):614-626.

Luderer U, Diaz D, Faustman EM, Kavanagh TJ. Localization of glutamate cysteine ligase subunit mRNA within the rat ovary and relationship to follicular apoptosis. Molecular Reproduction and Development 2003; 65 (3):254-61.

Luo T, Xia Z. A small dose of hydrogen peroxide enhances tumor necrosis factor-alpha toxicity in inducing human vascular endothelial cell apoptosis: reversal with propofol. Anesth Analg. 2006 Jul; 103(1):110-116.

Mar TF, Jansen K, Shepherd K, Lumley T, Larson TV, Koenig JQ. Exhaled nitric oxide in children with asthma and short-term PM2.5 exposure in Seattle. Environ Health Perspect. 2005 Dec; 113(12):1791-1794.

Mar TF, Koenig JQ, Jansen K, Sullivan J, Kaufman J, Trenga CA, Siahpush SH, Liu LJ, Neas L. Fine particulate air pollution and cardiorespiratory effects in the elderly. Epidemiology. 2005 Sep; 16(5):681-687.

Mar TF, Larson TV, Stier RA, Claiborn C, Koenig JQ. An analysis of the association between respiratory symptoms in subjects with asthma and daily air pollution in Spokane, Washington. Inhal Toxicol. 2004 Dec 1;16(13):809-15.

Martin MD, Benton T, Bernardo M, Woods JS, Townes BD, Luis H, Leitao J, Rosenbaum G, Castro-Caldas A, Pavao I, Rue T, Derouen TA. The association of dental caries with blood lead in children when adjusted for IQ and neurobehavioral performance. Sci Total Environ. 2007 Mar 13; [Epub ahead of print]

Martin MD, Woods JS. The safety of dental amalgam in children. Expert Opin Drug Saf. 2006; 5(6):773-781.

McKone EF, Shao J, Frangolias DD, Keener CL, Shephard CA, Farin FM, Tonelli MR, Pare PD, Sandford AJ, Aitken ML, Kavanagh TJ. Variants in the glutamate-cysteine-ligase gene are associated with cystic fibrosis lung disease. Am J Respir Crit Care Med. 2006 Aug 15; 174(4):415-419.

Moneypenny CG, Gallagher EP.. 4-Hydroxynonenal inhibits cell proliferation and alters differentiation pathways in human fetal liver hematopoietic stem cells. Biochem Pharmacol 2005; 69:105-112.

Moneypenny CG, Shao J, Song Y, Gallagher EP. MLL rearrangements are induced by low doses of etoposide in human fetal hematopoietic stem cells. Carcinogenesis. 2006 Apr; 27(4):874-881.

Moneypenny CG, Shao J, Song Y, Gallagher EP. Etoposide-induced DNA damage and MLL gene rearrangements in cultured human fetal liver hematopoietic stem cells. Carcinogenesis. 2006; 27(4)871-881.

Naeher LP, Brauer M, Lipsett M, Zelikoff JT, Simpson CD, Koenig JQ, Smith KR. Woodsmoke health effects: a review. Inhal Toxicol. 2007; 19(1):67-106.

Newhouse K, Hsuan S-L, Chang SH, Cai B, Wang Y, Xia Z. Rotenone-induced apoptosis is mediated by p38 and JNK MAP kinases in human dopaminergic SH-SY5Y cells. Toxicol Sci 2004; 79:137-146.

Nielsen SS, Mueller BA, De Roos AJ, Viernes HA, Farin FM, Checkoway H. Risk of brain tumors in children and susceptibility to organophosphorus insecticides. Environ Health Perspect 2005;113:909-913

Okada S, Farin FM, Stapleton P, Viernes H, Quigley SD, Powers KM, Smith-Weller T, Franklin GM, Longstreth WT, Swanson PD, Checkoway H. No associations between Parkinson’s disease and polymorphisms of the quinone oxidoreductase (NQO1, NQO2) genes. Neurosci Lett 2005; 375:178-80.

Peterson S, Lampe JW, Bammler TK, Gross-Steinmeyer K, Eaton DL. Apiaceous vegetable constituents inhibit human cytochrome P-450 1A2 (hCYP1A2) activity and hCYP1A2-mediated mutagenicity of aflatoxin B1. Food Chem Toxicol. 2006 Sep; 44(9):1474-1484.

Pham RT, Barber DS, Gallagher EP. GSTA is the major gene responsible for 4-hydroxynonenal metabolism in largemouth bass liver. Marine Environmental Res 2004; 58:485-488.

Poser S, Impey S, Xia Z, Storm DR. Brain-derived neurotrophic factor protection of cortical neurons from serum withdrawal-induced apoptosis is inhibited by cAMP. J Neurosci 2003; 23(11):4420-4427.

Schildcrout JS, Sheppard L, Lumley T, Slaughter JC, Koenig JQ, Shapiro GG. Ambient air pollution and asthma exacerbations in children: an eight-city analysis. Am J Epidemiol. 2006 Sep 15; 164(6):505-17. Epub 2006 Jun 23.

Sepulveda M, Gallagher EP, Gross TS. Effects of pulp mill effluents on health and reproductive parameters and in largemouth bass. Environ Sci Technol 2004; 57:431-440.

Sepulveda MS, Gallagher EP, Wieser CM, Gross TS. Reproductive and biochemical biomarkers in largemouth bass sampled downstream of a pulp and paper mill in Florida. Ecotoxicol Environ Saf 2004; 57(3):431-40.

Shao J, Stapleton PL, Lin YS, Gallagher EP. Cytochrome p450 and glutathione s-transferase mRNA expression in human fetal liver hematopoietic stem cells. Drug Metab Dispos. 2007; 35(1):168-175.

Sidhu JS, Ponce RA, Vredevoogd MA, Yu XZ, Gribble E, Hong SW, Schneider E, Faustman EM. Cell cycle inhibition by sodium arsenite in primary embryonic rat midbrain neuroepithelial cells. Toxicological Sciences 2006 Feb; 89 (2): 475-484.

Sieh W, Edwards KL, Fitzpatrick AL, Srinouanprachanh SL, Farin FM, Monks SA, Kronmal RA, Eaton DL. Genetic Susceptibility to Prostate Cancer: Prostate-specific Antigen and its Interaction with the Androgen Receptor (United States). Cancer Causes Control 2006 Mar; 17(2):187-197.

Slaughter C, Lumley T, Sheppard L, Koenig J, Shapiro GS. Effects of ambient air pollution on symptom severity and medication use in children with asthma. Ann Allergy Asthma Immunol 2003; 91:346-353.

Slikker W, Young JF, Corley RA, Dorman DC, Conolly RB, Knudsen TB, Erstad BL, Luecke RH, Faustman EM, Timchalk C, Mattison DR. Improving predictive modeling in pediatric drug development: Pharmacokinetics, pharmacodynamics, and mechanistic modeling. Annals of the New York Academy of Sciences; 1053:505-518.

Stan SD, Woods JS, Daeschel MA. Investigation of the presence of OH radicals in electrolyzed NaCl solution by electron spin resonance spectroscopy. J Agric Food Chem. 2005 Jun 15;53(12):4901-5.

Steiner C, Peters WH, Gallagher EP, Magee P, Rowland I, Pool-Zobel BL. Genistein protects human mammary epithelial cells from benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide and 4-hydroxy-2-nonenal genotoxicity by modulating the glutathione/glutathione S-transferase system. Carcinogenesis. 2007; 28(3):738-748.

Tang X, Wang X, Gong X, Tong M, Park D, Xia Z, Mao Z. Cyclin-dependent kinase 5 mediates neurotoxin-induced degradation of the transcription factor myocyte enhancer factor 2. J Neurosci 2005: 25(19):4823-4834.

Trenga CA, Sullivan JH, Schildcrout JS, Shepherd KP, Kaufman JD, Koenig JQ. Effect of particulate air pollution on lung function in adult and pediatric subjects in a Seattle panel study. Chest (In press).

Tsuji R, Guizzetti M, Costa LG. In vivo ethanol decreases phosphorylated MAPK and p70S6 kinase in the developing rat brain. Neuroreport 2003;14(10):1395-9.

White CC, Viernes H, Krejsa CM, Botta D, Kavanagh TJ. (2003). Fluorescence-based microtiter plate assay for glutamate-cysteine ligase activity. Anal Biochem 2003; 318(2):175-80.

Wong EY, Gohlke J, Griffith WC, Farrow S, Faustman EM. Assessing the health benefits of air pollution reduction for children. Environ Health Perspective 2004; 112(2):226-232.

Wong, EY, Ponce R.A, Farrow S, Bartell SM, Le RC, Faustman EM, Comparative risk and policy analysis in environmental health, Risk Anal, 23(6): 1337-49, 2003.

Yu XZ, Griffith WC, Hanspers K, Dillman JF, Ong H, Vredevoogd MA, Faustman EM. A system-based approach to interpret dose- and time-dependent microarray data: Quantitative integration of gene ontology analysis for risk assessment. Toxicological Sciences 2006 Aug; 92 (2): 560-577.

Zhou C, Poulton EJ, Grun F, Bammler TK, Blumberg B, Thummel KE, Eaton DL. The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor. Mol Pharmacol 2007; 71(1):220-229.

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Conference Presentations

Society of Toxicology: March 5–9, 2006, San Diego

Botta D, McConnachie LA, Fernandez C, Vliet PA, White CC, Kavanagh TJ. A model system to assess the role of modulated glutamate-cysteine ligase in toxicant induced oxidative stress

Cole TB, Pettan-Brewer C, Forbes A, Proll S, Furlong J, Costa LG, Furlong CE. Modulation of low-level organophosphate toxicity by human PON1, as assessed by microarray analysis

Fay KA, Simpson CD, Dills RL, Paulsen MH, Kavanagh TJ. Acidic extracts of wood smoke particulate matter cause caspase independent apoptosis in mouse RAW and MLE cells Flowers L, Barton HA, Faustman EM, Moore MM. Carcinogenic mode of action and US EPA’s 2005 Cancer Guidelines

Gallagher EP, Shao J, Moneypenny C, Eckert M, Stapleton P, Bammler T, Beyer R, Farin F. Mixed lineage leukemia gene rearrangements in human hematopoietic stem cells exposed to etoposide and chlorpyrifos

Gilbert SG. The Precautionary Principle: Implication and applications

Giordano G, Afsharinejad Z, Kavanagh T, Costa L. Reactive oxygen species mediate the neurotoxicity induced by organophosphorus insecticides in mouse cerebellar granule cells

Giordano G, White CC, Kavanagh TJ, Costa LG. Low concentration of domoic acid (DA) induces mitochondrially mediated apoptotic death in mouse cerebellar granule cells

Gribble EJ, Yu X, Hong S, Faustman EM. A role for p53 in mouse midbrain neural precursor cell (NPC) cell cycle arrest and premature neuronal differentiation following methylmercury exposure

Griffith WC, DeFrank NM, Gohlke JM, Gribble EJ, Faustman EM. Systems biology models for integration of diverse studies of the developing neocortex after exposure to low dose radiation from external and internal sources

Gross-Steinmeyer K, Zhu C, Stapleton PL, Tracy JH, Bammler TK, Strom SC, Thummel KE, Eaton DL. Down-regulation of CYP3A4 in human primary hepatocytes and human ls180 colorectal carcinoma cells by sulforaphane

McConnachie L, Mohar I, Kavanagh TJ. Gender differences in acetaminophen-induced hepatoxicity in wild-type and GCLM-null mice

Moore N, Guizzetti M, Gallis B, Shaffer S, Goodlett DR, Costa LG. Use of proteomic approaches for the identification of changes in astrocyte secretion following ethanol exposure Parent R, Eaton DL, Goldstein BD. Toxicology in the courtroom: Establishing causation

Peck EC, McConnachie LA, Beyer RP, Bammler TK, Baker C, Ceballos D, Vliet PA, Stewart JA, Luchtel DL, Kaufman JD, Kavanagh TJ. Differential gene expression in GCLM-null and wild-type mice exposed to diesel exhaust

Robinson JF, Yu X, Gribble EJ, Hong S, Kim E, Sidhu JS, Faustman EM. Examination of arsenic-induced alterations in cell cycle progression and global gene expression in p53 transgenic mouse embryonic fibroblasts

Trute M, LaVire H, Janssen P, Gallagher E. Characterization of hepatic and olfactory glutathione S-transferases of coho salmon (Oncorhynchus kisutch)

VanDeMark KL, Guizzetti M, Giordano G, Costa LG. Effect of ethanol on carbachol-induced neurite outgrowth in prenatal hippocampal neurons

Vitalone A, Catalani A, Chiodi V, Cinque C, Fattori V, Giacomi A, Matteucci P, Zuena A, Costa LG. Behavioral effects of perinatal exposure to PCB126 and methyl mercury, alone and in association

White CC, Dabrowski CM, Fernandez C, Botta D, Beyer R, Bammler TC, Kavanagh TJ. Differential gene expression in hepatocyte subpopulations sorted from acetaminophen-treated mice

Xia Z, Choi W, Klintworth H, Hsuan S, Kruse S, Palmiter R. Molecular mechanisms underlying dopaminergic cell death

Yu X, Griffith WC, Hanspers K, Robinson J, Faustman EM. Functional interpretation of dose and time-dependent microarray data: Quantitative integration of GO ontology analysis for toxicology and risk assessment

National Toxicology Program, National Academy of Sciences: May 11, 2005, Washington, DC

Eaton D. Functional genomics and public health decisions

Faustman E. Systems biology in public health decisions

Society of Toxicology: March 6–10, 2005, New Orleans

The DEOHS Toxicology program was well represented at this year’s annual Society of Toxicology meeting. Professor Elaine Faustman serves on the SOT Council. Professor Dave Eaton organized and moderated a panel discussion on reorganization of NIH study sections and funding of toxicology grants. Affiliate Associate Professor Steve Gilbert organized the alumni reception. Graduate student Heather Klintworth received a travel award for the conference.

Bekris L, Janer M, Kavanagh T, Lernmark A. The glutamate cysteine ligase catalytic subunit -129 C/T single nucleotide polymorphism is associated with the level of GAD65 auto-antibodies in Type 1 diabetes patients with a delayed age-at-onset

Cole T, Walter B, Shih D, Tward A, Lusis A, Costa L, Furlong C. Toxicity of chlorpyrifos and chlorpyrifos oxon in a transgenic mouse model of the human paraoxonase (PON1) Q192R polymorphism

Echeverria D, Woods J, Heyer N, Farin F, Bittner A, Li T, Garabedian C. Associations between mercury, BDNF poly-morphism, and attentional attributes of motor function

Ellis M, Polk W, Kushleika J, Simmonds P, Woods J. RhoA/ROCK signaling negatively regulates nuclear factor kappa B (NF-B) activation via modulation of IB levels in kidney epithelial cells

Faustman E, Yu X, Sidhu J, Robinson J. Toxicant affects on ubiquitin-proteosome systems: Lessons from cross-compound and cross-system assessments

Gohlke J, Griffith W, Faustman E. Computational models for the acquisition of neocortical neurons in the developing human, monkey, and mouse: Cross species comparison of toxicodynamics

Griffith W, Vigoren E, Faustman E. Quantitative models of bystander effects from ionizing radiation in non-targeted cells

Gross-Steinmeyer K, Stapelton P, Liu F, Tracy J, Bammler T , Strom S, Eaton D. Altered transcriptional regulation of genes involved in aflatoxin genotoxicity by sulforaphane (SFN) and diindolylmethane (DIM)

Guizzetti M, Pathak S, Giordano G, Costa L. Effect of organophosphorus insecticides and their metabolites on DNA synthesis in astroglial cells

Ho H, White C, Fernandez C, Fausto N, Kavanagh T, Nelson S, Bruschi S. Nrf2 activation involves an oxidative-stress independent pathway in tetrafluoroethylcysteine-induced cytotoxicity

Klintworth H, Xia Z. Signaling pathways of paraquat-induced apoptosis: A model for Parkinson’s disease

McConnachie L, Fernandez C, Mohar I, Pierce R, Kavanagh T. Acetaminophen induced hepatoxicity in a GCLM- null mouse model

Mohar I, McConnachie L, Fernandez C, Kavanagh T. Effect of acetaminophen on cytosolic and mitochondrial glutathione in the livers of wild-type, GCLM-heterozygous, and GCLM-null mice

Moneypenny C, Stapleton P, Gallagher E. Effects of etoposide on human fetal hematopoietic stem cells

Pettan-Brewer C, Cole T, Fisher J, Walter B, Forbes A, Yee N, Costa L, Furlong C. PON1 modulates OP toxicity during development

Polk W, Kushleika J, Ellis M, Simmonds P, Woods J. Protein kinase C mediates LPS activation of nuclear factor kappa B (NF-B) in kidney epithelial cells

Prophete C, Maciejczyk P, Salnikow K, Gould T, Larson T, Jaques P, Koenig J, Sioutas C, Lippmann M, Cohen M. Effects of PM-associated metals on macrophage iNOS and ERK: A role in altered iron homeostasis?

Robinson J, Yu X, Sidhu J, Hong S, Kim E, Faustman E. Examination of metal-induced cell cycle alterations and apoptosis in C57BL/6 and SWV mouse embryonic fibroblasts

Robison S, Needham L, Faustman E, Zenick H, Sheldon L. Integration of biomonitoring data into the risk assessment process

Shi S, Botta D, Bammler T, Beyer R, Kavanagh T. Prediction of transcription factors commonly affected by glutamate-cysteine ligase expression in mice exposed to acetaminophen, carbon tetrachloride or tumor necrosis factor

Wang Y, Liu L, Xia Z. ERK1/2-RSK2 stimulation of MEF2C transcription promotes cortical neuron survival

Yu X, Sidhu J, Robinson J, Hong S, Faustman E. Integrative analysis of genome-wide gene expression and pathway mapping in mouse embryonic fibroblast (MEF) exposed to cadmium, arsenic and methylmercury: Induction of oxidative stress, disruption of ubiquitin-proteasome system and cell cycle regulation

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