FACULTY
Evan Gallagher, PhD, MEM
Professor, Env. and Occ. Health Sciences
Dr. Gallagher joined the faculty of the University of Washington in 2004 as Sheldon D. Murphy Associate Professor of Toxicology. Dr Gallagher was formerly an Associate Professor at the University of Florida were he also served as Director of the Aquatic Toxicology Laboratory in the College of Veterinary Medicine. Dr Gallagher serves on the editorial boards of Toxicological Sciences and Environmental Research and is an active member of the UW Center for Ecogenetics and Environmental Heath (CEEH) . He is a member of the Society of Toxicology as well as the Society of Environmental Toxicology and Chemistry. Dr. Gallagher maintains an active research and teaching program focused in the area of the molecular and biochemical basis for susceptibility of environmental chemical toxicity. Specifically, his work is directed toward an understanding of the role of genetics and biochemistry of oxidative defense and biotransformation enzyme expression in individual, developmental, and species' differences in susceptibility to environmental chemicals. His work encompasses studies in marine fish as well as in human cell models, and thus allows for a unique perspective on toxicological issues that cross ecosystem and human health boundaries. Accordingly, students and post-docs in Dr. Gallagher's laboratory potentially have the opportunity to work in the areas of mechanistic marine toxicology or in biomedical toxicology.
Contact Information
Box 3572344225 Roosevelt Way NE
Suite 100
Seattle, WA 98105-6099
Tel: 206-616-4739
Tel: 206-543-1005
Fax: 206-685-4696
evang3@u.washington.edu
Research Interests
Aquatic Toxicology, Drug Metabolism, Pesticides, Childhood Leukemia, Superfund Sites, Toxicogenomics
Education
PhD, Biochemical Toxicology, Duke University 1991
MEM, Environmental Management, Duke University 1986
Projects
Funding from NIEHS and the U.S. Environmental Protection Agency supports investigations regarding mechanisms of aldehyde-induced oxidative liver damage as well as the role of in utero gene environment interactions in transplacental chemical exposure and susceptibility to childhood leukemia. These studies are largely focusing on human hematopoietic stem cells as targets for maternally transferred carcinogens. Other current human toxicology studies target the role of glutathione S -transferase enzymes in susceptibility to chemical toxicities and environmental carcinogenesis.
We are currently using toxicogenomic approaches to identify pathways and mechanisms of chemical injury in salmonids. The genomic studies are part of an ongoing initiative involving in vivo and in vitro techniques to investigate the regulation of pollutant detoxification pathways in fish. Practical applications of our aquatic work involve the development and field application of biochemical and molecular biomarkers of pollutant exposure and effects, as well as the identification of those aquatic species at high risk to chemical injury. The salmonid toxicology work is part of an ongoing collaboration with research investigators at the Northwest Fisheries Science Center in Seattle.
