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Epi Special Seminar

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Tuesday, December 7, 2010
Health Sciences Building
K-069
3:30 to 4:50pm

Studying Genetic and Environmental risk factors for colorectal cancer- how to navigate the world of consortia?

Riki Peters  

Ulrike (Riki) Peters, PhD, MPH


Research Associate Professor
Department of Epidemiology
School of Public Health, UW

 

Associate Member
Fred Hutchinson Cancer Center

 

 

Short Bio:

Riki Peters received her PhD in nutrition at the University of Kiel, and MPH in epidemiology at the University of North Carolina at Chapel Hill. Following a post-doctoral fellowship at the National Institutes of Health, Dr. Peters has worked at the Fred Hutchinson Cancer Research Center (FHCRC) as a nutritional and genetic epidemiologist since 2004. In addition to her position as an Associate Member at FHCRC, she also holds an Associate Research Professor appointment at the University of Washington. Her work at FHCRC has primarily focused on genetic and nutritional risk factors for colorectal and prostate cancer, and particularly the interaction between genetics and nutrition in assessing cancer risk. Dr. Peters’ research utilizes blood, DNA and tissue samples from well characterized study populations to investigate the roles of selenium, vitamin D, calcium and other factors in the prevention of prostate and colorectal cancer. Among her current projects, Dr. Peters leads an international consortium of genome-wide association studies to investigate the genetic and epidemiologic architecture of colorectal cancer, including pathway analysis, complex risk modeling, rare variants, gene-gene and gene-environment interactions. Dr. Peters is a recent recipient of the Presidential Early Career Award for Scientists and Engineers, which will further support her work in cancer prevention.

Brief abstract of talk:

It has been estimated that about one third of risk of colorectal cancer is due to genetic risk factors while two thirds are related to environmental risk factors, particularly dietary factors.  Observational studies and clinical trial have identified several environmental contributors and linkage and genome-wide association studies have identified the first genetic risk factors.  To identify additional genetic risk factors as well as interactions between genetic and environmental risk factors increasingly large samples sizes are needed, which requires to build collaborations across multiple well characterized studies.


Suggested readings:

 

Updated on October 13, 2010