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Epi Seminar Series

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Epidemiology Seminar
Tuesday, March 5, 2013
Health Sciences K-069
3:30 pm to 4:50 pm

"
Maternal Vitamin D and Perinatal Outcomes"

Dr. Enquobahrie

 


Daniel A. Enquobahrie, PhD, MPH, MD
Assistant Professor, Epidemiology
Associate Director of Research, Center for Perinatal Studies

Abstract:

Vitamin D, a pleotropic hormone, serves as a nuclear transcription factor that alters gene function and translation of genetic information.  Through vitamin D receptors present throughout the body, vitamin D also controls hundreds of genes that contain vitamin D response elements. Effects of vitamin D include suppression of the renin-angiotensin-aldosterone system, blood pressure reduction, modulation of immune function, increased glucose metabolism, increased muscle function, and modulation of cell growth (decreased proliferation, increased differentiation, and decreased apoptosis). Physiologic increase in vitamin D levels is observed during pregnancy.  Ubiquity of vitamin D receptors, easy passage of vitamin D to the fetus through placenta, and the diverse functions of vitamin D indicate potentially important roles of maternal vitamin D on course and outcomes of pregnancy.  However, associations of maternal vitamin D levels with maternal and offspring pregnancy outcomes have not been fully explored. Further, mechanisms for potential associations of low vitamin D with adverse perinatal outcomes are largely unknown. The presentation will describe our ongoing work in this research area.


About the Speaker:

Dr. Enquobahrie, Assistant Professor of Epidemiology, is a perinatal and cardiovascular epidemiologist with additional training in public health genetics. He has been involved in teaching, mentoring, and research in areas that span reproductive, perinatal, cardiometabolic, and genetic epidemiology, both domestically and internationally. Dr. Enquobahrie is an investigator with the Cardiovascular Health Research Unit and Associate Director of the Center for Perinatal Studies at the Swedish Medical Center. He teaches “Epidemiology of Maternal and Child Health Problems (EPI521/HSERV542)” and is co-director of the Reproductive, Pediatric, and Perinatal Epidemiology Training program.

 

Updated on February 19, 2013