Annette L. Fitzpatrick, PhD, MA, BS

Research Associate Professor, Epidemiology
Adjunct Research Associate Professor, Global Health

Senior Faculty Investigator, Collaborative Health Studies Coordinating Center (CHSCC), Department of Biostatistics

Core Faculty, Multidisciplinary International Research Training (MIRT)Program, Department of Epidemiology

Contact Information
Box 354922
Collaborative Health Studies Coordinating Center
6200 NE 74th Street, Suite 310
Bldg. 29, Box 354922
Seattle, WA 98155
Tel: 206-897-1903
Tel: 206-616-5647
Fax: 206-616-4075
fitzpal@u.washington.edu

Research Interests
Studies of aging and chronic diseases; cardiovascular disease and its risk factors; physical and cognitive functioning in the elderly, dementia including Alzheimer's disease and vascular dementia, health aging, and alternative and complementary approaches to health; chronic disease in developing countries.

Education
PhD, Epidemiology, University of Washington 1999
MA, Zoology, Southern Illinois University 1981
BS, Biology, Loyola University (Chicago) 1975

Projects
The Cardiovascular Health Study (CHS) Coordinating Center (N01 HC85079) funded by the National Heart, Lung and Blood Institute (NHLBI). Role: Co-Investigator, prior Program Director. The Coordinating Center has organized the CHS Field Centers in this prospective study that is investigating risk factors for coronary heart disease and stroke in the elderly (ages 65-84).

The Ginkgo Evaluation of Memory (GEM ) Study (U01 AT00162) funded by the National Center for Complementary and Alternative Medicine (NCCAM). Role: Co-Investigator, Program Director. The coordinating center for this randomized, double-blind, placebo-controlled clinical trial coordinates all aspects of data collection, management, and analysis for a randomized, double-blind, placebo-controlled, multi-site prevention trial to determine the efficacy of Ginkgo biloba in delaying or preventing the onset of dementia in older adults.

The Multi-Ethnic Study of Atherosclerosis (MESA) Coordinating Center (N01 HC95159) funded by the National Health, Lung and Blood Institute (NHLBI). Role: Co-Investigator. This is a national study to identify risk factors for sub-clinical CVD and to explore the transition from sub-clinical to overt CVD, in a cohort of 6,800 participants age 45-84 of Caucasian, African-American, Hispanic and Chinese ethnicity.

Telomeres and Biologic Aging funded by a UW Royalty Research Award. Role: Principal Investigator. This is a locally funded project to investigate the role of telomeres, the ends of chromosomes that reduce in length with each cell replication, and which may be modified by the presence of certain diseases, in the prediction of mortality in the elderly using blood samples from the Cardiovascular Health Study cohort.

The Cardiovascular Health Intervention Research Network is a collaboration of six universities funded by the Centers for Disease Control (1 U48 DP000312-01) to study CVD in underserved populations. Studies resulting from this grant have included use of Photovoice in assessing perceptions of cardiovascular health in Asian immigrants, displaying posters in Seattle buses to promote stroke awareness, and production to a radio novella in Spanish to increase awareness of stroke signs and symptoms.

The Nepal Heart Health Study is a collaboration between the UW, Harvard University and the Shahid Gangalal National Heart Center in Kathmandu to develop a protocol and collect data on prevalence and risk factors for heart disease and stroke in Nepal. The project was funded by the UW Royalty Research Fund and Dr. Fitzpatrick is PI.

Selected Publications
Fitzpatrick AL, Kuller LH, Lopez OL, Diehr P, O'Meara ES, Longstreth WT, Luchsinger J. Mid- and late-life obesity: risk of dementia in the Cardiovascular Health Cognition Study. Arch Neurology 2009; 66:336-342.

Burnett-Hartman A, Fitzpatrick AL, Gao K, Jackson SA, Schreiner PJ. The contributions of supplement use in meeting RDAs/AIs in four ethnicities of middle-aged and older American: the Multi-Ethnic Study of Atherosclerosis. J Am Diet Assoc 2009; 109:422-429.

Velez JC, Fitzpatrick AL, Barbosa CI, Diaz M, Urzua M, Andrade AH. Nutritional status and obesity in children and young adults with disabilities in Punta Arenas (Pategonia), Chile. Int J Rehabil Res 2008; 31:305-13.

DeKosky ST, Williamson JD, Fitzpatrick AL, Kronmal RA, Ives DG, Saxton JA, Lopez OL, Burke G, Carlson MC, Fried LP, Kuller LH, Robbins JA, Tracy RP, Woolard NF, Dunn L, Snitz BE, Nahin RL, Furberg CD, for the Ginkgo Evaluation of Memory (GEM) Study Investigators. Ginkgo biloba for prevention of dementia: a randomized controlled trial. JAMA 2008;300:2253-2262.

Gao, SK, Beresford SA, Frank LL, Schreiner PJ, Burke GL, Fitzpatrick AL. Modifications in the Healthy Eating Index and its ability to predict obesity: the Multi-Ethnic Study of Atherosclerosis. Am J Clin Nutr 2008; 88:64-9.

Diehr P, O'Meara ES, Fitzpatrick AL, Newman AB, Kuller L, Burke G. Weight, mortality, years of healthy life and active life expectancy in older adults. J Am Geriatr Soc 2008; 56:76-83.

Fitzpatrick, AL, Buchanan C, Nahin R, DeKosky S, Atkinson H, Carlson M, Williamson J. Associations of gait speed and other measures of physical function with cognition in a healthy cohort of elderly persons. J Gerontol Med Sci 2007;62A:1244-1251

Szekely CA, Breitner JCS, Fitzpatrick AL, Rea TD, Psaty BM, Kuller LH, Zandi PP. NSAID use and dementia risk in the Cardiovascular Health Study: Role of APOE and NSAID type. Neurology 2008; 70:17-24.

Irie F, Fitzpatrick AL, Kuller LH, Newman A, Lopez OL, Peilar, Launer L. Enhanced risk for AD in type 2 diabetes with APOE 4: the Cardiovascular Health Cognition Study. Archives of Neurology 2008; 65:89-93.

Fitzpatrick AL, Kronmal RA, Gardner JP, Psaty BM, Jenny NS, Tracy RP, Walston J, Kimura M, Aviv A. Leukocyte telomere length and cardiovascular disease in the Cardiovascular Health Study. Am J Epidemiology 2007;165:14-21.

Nahin RL, Fitzpatrick AL, Williamson JD, Burke G, DeKosky S, Furberg C. Use of herbal medicine and other dietary supplements in the community-dwelling elderly: Baseline data from the GEM Study. J Am Geriatr Soc 2006; 54: 1725-35.

Fitzpatrick AL, Fried LP, Williamson J, Crowley P, Posey D, Kwong L, Bonk J, Moyer B, Chabot J, Kidoguchi L, DeKosky ST, Furberg C. Recruitment of the elderly into a pharmacologic prevention trial: The Ginkgo Evaluation of Memory Study. Contemporary Clinical Trials 2006; 27:541-553.

Newman AB, Fitzpatrick AL, Lopez OL, Jackson S, Lyketsos C, Jagust WJ, Ives D, DeKosky ST, Kuller LH. Dementia and Alzheimer's disease incidence in relationship to cardiovascular disease in the Cardiovascular Health Study cohort. J Am Geriatr Soc 2005;53:1101-7.

Huang TL, Carlson MC, Zandi PP, Fried LP, Kuller LH, Fitzpatrick AL, Burke GL, Tucker KL. Benefits of Fatty Fish for Dementia Risk Are Stronger for Those without APOE ε4. Neurology 2005;65:1409-14.

Fitzpatrick AL, Kuller LH, Lopez OL, Kawas CH, Jagust W. Survival following dementia onset: Alzheimer's disease and vascular dementia. J Neurol Sci 2005 229-230:43-49.

Kuller LH, Lopez OL, Jagust WJ, Becker JT, DeKosky ST, Lyketsos C, Kawas C, Breitner JCS, Fitzpatrick AL, Dulberg C. Determinants of vascular dementia in the Cardiovascular Health Cognition Study. Neurology 2005;64:1548-1552.

Lopez OL, Kuller LH, Becker JT, Jagust WJ, DeKosky ST, Fitzpatrick AL, Dulberg C, Breitner JCS, Lyketsos C, Kawas C, Carlson M. Classification of vascular dementia in the Cardiovascular Health Cognition Study. Neurology 2005;64:1539-1547.

Fitzpatrick AL, Powe NR, Cooper LS, Ives DG, Robbins JA. Barriers to health care access among the elderly and who perceives them. Am J Public Health 2004; 94:1788-1794

Fitzpatrick AL, Reed T, Goldberg J, Buchwald D. The association between prolonged fatigue and cardiovascular disease in World War II veteran twins. Twin Research 2004; 7:571-7

Fitzpatrick AL, Kuller LH, Ives D, Lopez OL, Jagust W, Breitner J, Beauchamp N, Lyketsos C, Dulberg C. Incidence and Prevalence of Dementia in the Cardiovascular Health Study. J Am Geriatr Soc 2004; 52:195-204.

Mukamal KJ, Kuller LH, Longstreth WT, Mittleman MA, Fitzpatrick AL, Siscovick DS. A prospective study of alcohol consumption and risk of dementia in older adults: The Cardiovascular Health Study. JAMA 2003; 289:1405-1413.