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Frits R. Rosendaal, MD

Affiliate Professor, Epidemiology

Contact Information
Leiden University
Leiden University Medical Center (LUMC) Clinical Epidemiology, C9-P
P.O. Box 9600
Tel: 71 -526-4037
Fax: 71 -526-6994

Research Interests
His main research interest is hemostasis and thrombosis. The Leiden center is active in studies on the etiology of thrombosis, management of thrombosis and quality control of anticoagulant therapy, and treatment and complications of bleeding disorders (hemophilia, von Willebrand disease). These studies are performed in a close collaboration of clinical and laboratory scientists. Ongoing studies focus on genetic abnormalities predisposing to thrombosis, studies of gene-environment interaction, in particular with oral contraceptives and hormone replacement therapy, studies on safety of anticoagulant treatment, and national surveys of morbidity and mortality in hemophilia. Over the last few years, the Leiden center has been first to describe several new risk factors for thrombosis, such as factor V Leiden, prothrombin 20210A, high levels of factor VIII, of factor IX and of factor XI, and has also provided prevalence and risk estimates for these risk factors. It has also first described interactions of some of these genetic factors with oral contraceptives on the risk of venous thrombosis, and with postmenopausal estrogens on the risk of arterial disease.

MD, Medicine, Erasmus University (Rotterdam) 1985

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