Nicholas L. Smith, PhD, MPH

Associate Professor, Epidemiology

Dr. Smith is an Associate Professor of Epidemiology and Director of the VA Seattle Epidemiologic Research and Information Center (ERIC) at the VA Puget Sound Health Care System

Contact Information
Cardiovascular Health Research Unit
Box 358085
1730 Minor Avenue, Suite 1360
Seattle, WA 98101
Tel: 206-287-2784
Fax: 206-287-2662
http://depts.washington.edu/chru/
nlsmith@u.washington.edu

Research Interests
Dr. Nicholas L. Smith conducts cardiovascular pharmacoepidemiology, clinical epidemiology, and health services research at the CHRU and the Seattle ERIC. Cardiovascular outcomes of interest include myocardial infarction, ischemic and hemorrhagic stroke, venous thromboembolism, and congestive heart failure. Exposures of interest include pharmaceuticals, genetic variants, biochemical measures, traditional cardiovascular risk factors and their attending interactions. His research interests also include the provision of health care services and treatment in both community-based and health plan-based populations.

Teaching Interests
Dr. Smith co-teaches EPI/HSERV 548, Social Determinants of Health Research Methods in Winter Quarter.

Education
PhD, Epidemiology, University of Washington 1997
MPH, Epidemiology/Biostatistics, University of California (Berkeley) 1993

Selected Publications
Smith NL, Croft JB, Heath GW, Cokkinides V. Changes in cardiovascular disease knowledge and behavior in a low-education population of African-American and White adults. Ethn Dis 1996;6:244-254.

Smith NL, Psaty BM, Heckbert SR, Lemaitre RN, Kates DM, Rutan GH, Bleyer A. The association of anti-hypertensive medication with serum creatinine changes in older adults. Am J Hypertens 1997;10:1368-1377.

Smith NL, Psaty BM, Pitt B, Garg R, Gottdiener JS, Heckbert SR. Temporal patterns in the medical treatment of congestive heart failure with angiotensin-converting enzyme inhibitors in older adults, 1989-1994. Arch Intern Med 1998;158:1074-1080.

Smith NL, Reiber GE, Psaty BM, Heckbert SR, Siscovick DS, Ritchie J, Every NR, Koepsell TD. Health Outcomes Associated with Beta-Blocker and Diltiazem Treatment of Unstable Angina. J Am Coll Cardiol 1998;32:1305-1311.

Smith NL, Psaty BM, Heckbert SR, Tracy RP, Cornell ES. The Reliability of Medication Inventory Methods Compared to Serum Levels of Cardiovascular Drugs in the Elderly. J Clin Epidemiol 1999;52:143-146.

Smith NL, Psaty BM, Furberg CD, White R, Lima JAC, Newman AB, Manolio TA. Temporal Trends in the Use of Anticoagulants among Older Adults with Atrial Fibrillation. Arch Intern Med 1999;159:1574-1578.

Smith NL, Heckbert SR, Bittner VA, Savage PJ, Barzilay J, Dobs AS, Psaty BM. Antidiabetic treatment trends in a cohort of elderly persons with diabetes: the Cardiovascular Health Study 1989-1997. Diabetes Care 1999:22:736-742.

Smith NL, Reiber GE, Psaty BM, Heckbert SR, Siscovick DS, Ritchie J, Every NR, oepsell TD. Trends in the post-hospitalization medical treatment of unstable angina pectoris: 1990 to 1995. Am J Cardiol 1999;84:632-638.

Smith NL, Barzilay JI, Shaffer D, Savage PJ, Heckbert SR, Kuller LH, Kronmal RA, Resnick HE, Psaty BM. Fasting and 2-hour post-challenge serum glucose measures and risk of incident cardiovascular events in the elderly: The Cardiovascular Health Study. Arch Intern Med 2002;162:209-216.

Smith NL, Savage PJ, Heckbert SR, Barzilay JI, Bittner VA, Kuller LH, Psaty BM. Glucose, blood pressure, and lipid control among elderly women and men with and without diabetes: the Cardiovascular Health Study. J Am Geriatr Soc 2002;50:416-423.

Smith NL, Psaty BM, Rutan GH, Lumley T, Yanez T, Chaves PHM, Kronmal RA. The association between time-since-last-meal and blood pressure among older adults: The Cardiovascular Health Study. J Am Geriatr Soc 2003;51:824-8.

Smith NL, Lemaitre RN, Heckbert SR, Kaplan RC, Tirschwell DL, Longstreth WT, Psaty BM. Serum potassium and stroke risk among treated hypertensive adults. Am J Hypertens 2003;16:806-813.

Smith NL, Maynard C. The Burden of Diabetes-Associated Cardiovascular Hospitalizations in Veterans Administration (VA) and Non-VA Medical Facilities. Diabetes Care 2004;27 Suppl 2:B27-B32.

Smith NL, Chen L, Au DH, McDonell M, Fihn SD. Cardiovascular Risk Factor Control Among Veterans With Diabetes: The Ambulatory Care Quality Improvement Project. Diabetes Care 2004;27 Suppl 2:B33-B38.

Smith NL, Chan JD, Rea TD, Wiggins KL, Gottdiener JS, Lumley T, Psaty BM. Time trends in the use of beta blockers and other pharmacotherapies in older adults with congestive heart failure. Am Heart J 2004;148:710-7.

Smith NL, Heckbert SR, Lemaitre RN, Reiner AP, Lumley T, Weiss NS, Larson EB, Rosendaal FR, Psaty BM. Esterified estrogens and conjugated equine estrogens and the risk of venous thrombosis. JAMA 2004;292:1581-7.

Smith NL, Heckbert SR, Doggen CJ, Lemaitre RN, Reiner AP, Lumley T, Meijers JCM, Psaty BM, Rosendaal FR. The differential association of conjugated equine estrogen and esterified estrogen with activated protein C resistance in post-menopausal women. J Thromb Heamost 2006;4:1701-6.

Smith NL, Barzilay JI, Kronmal R, Lumley T, Enquobahrie D, Psaty BM. New-onset diabetes mellitus and risk of all-cause and cardiovascular mortality: the Cardiovascular Health Study. Diabetes Care 2006;29:2012-7.

Smith NL, Heckbert SR, Lemaitre RN, Reiner AP, Lumley T, Rosendaal FR, Psaty BM. Conjugated equine estrogen, esterified estrogen, prothrombotic variants and the risk of venous thrombosis in post-menopausal women. Arterioscler Thromb Vasc Biol 2006;26:2807-12.

Smith NL, Hindorff LA, Heckbert SR, Lemaitre RN, Marciante KD, Rick K, Lumley T, Bis JC, Wiggins KL, Rosendaal FR, Psaty BM. Variation in 24 coagulation, anti-coagulation, fibrinolysis, and anti-fibrinolysis genes and associations with non-fatal venous thrombosis in post-menopausal women. JAMA 2007;297:489-98.

Smith NL, Bis JC, Biagiotti S, Rice K, Lumley T, Kooperburg C, Wiggins KL, Heckbert SR, Psaty BM. Variation in 24 hemostatic genes and associations with non-fatal myocardial infarction and ischemic stroke. J Thromb Heamost 2008;6:45-53.

Smith NL, Wiley JR, Legault C, Rice KM, Heckbert SR, Psaty BM, Tracy RP, Cushman M. Effect of progestogen and progestogen type on hemostatic markers in postmenopausal women: the Postmenopausal Estrogen/Progestin Intervention (PEPI) Study. Menopause (in press)