Research Associate Professor, Epidemiology
EducationPhD Epidemiology, University of Washington, 1996
MPH Epidemiology, Yale University, 1991
Division of Public Health Sciences, Epidemiology Program
1100 Fairview Ave N., Building M
PO Box 19024, Mailstop: M4-C313
Seattle, WA 98109
Margaret M. Madeleine, MPH, PhD, is an Assistant Research Profession in the Department of Epidemiology in the School of Pulic Health at the University of Washington and an Assistant Member, Program in Epidemiology, Fred Hutchinson Cancer Research Center. She obtained her undergraduate degree in English literature, with a minor in biology. She began her career as a Staff Scientist at the Hutch, and was the project director for case-control studies of HPV-related cancers. She has been a key member of the Seattle HPV group that won the Team Science Award, from the American Association of Cancer Research, in 2011.
My research focuses on the epidemiology of infection-related cancer, especially HPV-related cancers and pre-cancerous lesions. I have led studies that examine the immunogenetics of HPV-related cervical and vulvar neoplasia, with a focus on HLA alleles, and continue to follow up on that work as a leader in the International Cervical Cancer Consortium. My recently completed cohort study on Skin Cancer after Organ Transplant (the SCOT study) examined the role of cutaneous HPV in non-melanoma skin cancer.
Dr. Madeleine's major research focus is on the molecular epidemiology of pathogens and our immune response to them that may be associated with cancer development and prognosis. I am also interested in the common drivers behind the role that chronic subclinical inflammation (such as occurs with age, obesity, physical inactivity, hormone use, and UV exposure) plays in cancer.
Dr. Madeleine teaches EPI 540 "Introduction to Cancer Biology" in spring quarter of even years.
Coghill AE, Newcomb PA, Madeleine MM, Richardson B, Mutyaba I, Okuku F, Phipps WT, Orem J, Casper C. Contribution of HIV Infection to Mortality among Cancer Patients in Uganda. AIDS, 2013; Aug 6, online.
Madeleine MM, Finch FL, Goodman MT, Engels EA. HPV-Related Cancers after Solid Organ Transplantation in the U.S. Am J Transplant. 2013: Oct 3, online.
Madeleine MM, Johnson LG, Smith AG, Hansen JA, Nisperos BB, Li S, Zhao LP, Daling JR, Schwartz SM, Galloway DA. Comprehensive analysis of HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 loci and squamous cell cervical cancer risk. Cancer Res 2008; 68:3532-3539. PMCID: PMC 2662593
Bodelon C, Madeleine MM, Johnson LG, Du Q, Malkki M, Petersdorf EW, Schwartz SM. Genetic variation in CD83 and risks of cervical and vulvar cancers: A population-based case-control study. Gynecol Oncol 2012;124(3):525-8.
Johnson LG, Schwartz SM, Malkki AM, Du Q, Petersdorf EW, Galloway DA, Madeleine MM. Risk of cervical cancer associated with allergies and polymorphisms in genes in the chromosome 5 cytokine cluster. Cancer Epidemiol Biomarkers Prev 2011; 20:199-207. PMCID: PMC3057941
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