School of Public Health

Smith, Nicholas

Nicholas Smith

Professor, Epidemiology

Affiliate Investigator at Group Health Research Institute, Group Health Cooperative


PhD Epidemiology, University of Washington, 1997

Contact Info

Cardiovascular Health Research Unit
Box 358085
1730 Minor Avenue, Suite 1360
Seattle, WA 98101
Tel: 206-221-1279

Dr. Smith is Professor of Epidemiology and Director of the VA Seattle Epidemiologic Research and Information Center (ERIC) at the VA Puget Sound Health Care System


For more publications view Dr. Smith's CV

Research Interests

Dr. Nicholas L. Smith conducts cardiovascular pharmacoepidemiology, genetic epidemiology, clinical epidemiology, and health services research at the Cardiovascular Health Research Unit and the Seattle ERIC. Cardiovascular outcomes of interest include myocardial infarction, ischemic and hemorrhagic stroke, venous thrombosis, and heart failure. Exposures of interest include pharmaceuticals, genomic variation, biochemical measures, traditional cardiovascular risk factors, and their attending interactions. His research interests also include the provision of health care services and treatment in both community-based and health plan-based populations.

Teaching Interests

Dr. Smith co-teaches EPI/HSERV 548, Social Determinants of Health Research Methods in Winter Quarter.


1. Smith NL, Heckbert SR, Lemaitre RN, Reiner AP, Lumley T, Weiss NS, Larson EB, Rosendaal FR, Psaty BM. Esterified estrogens and conjugated equine estrogens and the risk of venous thrombosis. JAMA 2004;292:1581-7.
2. Smith NL, Heckbert SR, Doggen CJ, Lemaitre RN, Reiner AP, Lumley T, Meijers JCM, Psaty BM, Rosendaal FR. The differential association of conjugated equine estrogen and esterified estrogen with activated protein C resistance in post-menopausal women. J Thromb Heamost 2006;4:1701-6.
3. Smith NL, Heckbert SR, Lemaitre RN, Reiner AP, Lumley T, Rosendaal FR, Psaty BM. Conjugated equine estrogen, esterified estrogen, prothrombotic variants and the risk of venous thrombosis in post-menopausal women. Arterioscler Thromb Vasc Biol 2006;26:2807-12.
4. Smith NL, Hindorff LA, Heckbert SR, Lemaitre RN, Marciante KD, Rick K, Lumley T, Bis JC, Wiggins KL, Rosendaal FR, Psaty BM. Variation in 24 coagulation, anti-coagulation, fibrinolysis, and anti-fibrinolysis genes and associations with non-fatal venous thrombosis in post-menopausal women. JAMA 2007;297:489-98.
5. Smith NL, Chen M, Dehghan A, Strachan DP, Basu S, Bis JC, de Maat M, Rumley A, Kong X, Yang Q, Wiggins KL, Van Duijn C, McArdle WL, Pankow JS, Johnson AD, McKnight B, Uitterlinden A, Wellcome Trust Case Control Consortium, Aleksic N, Meigs JB, Peters A, Koenig W, Cushman M, Kathiresan S, Rotter JI, Bovill EG, Hofman A, Boerwinkle E, Tofler GH, Psaty BM, Leebeek F, Folsom AR, Larson MG, Lumley T, Witteman JC, Tang W, O’Donnell JC. Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE Consortium. Circulation 2010;121:1382-92. (PMC2861278)
6. Smith NL, Felix JF, Morrison AC, Demissie S, Glazer NL, Loehr LR, Cupples LA, Dehghan A, Lumley T, Rosamond W, Lieb W, Rivadeneira F, Bis JC, Folsom AR, Benjamin E, Aulchenko YS, Haritunians T, Couper D, Murabito J, Stricker BH, Gottdiener JS, Chang PP, Wang TJ, Rice KM, Hofman A, Heckbert SR, Fox ER, O'Donnell CJ, Uitterlinden AG, Rotter JI, Willerson JT, Levy D, van Duijn CM, Psaty BM, Witteman JCM, Boerwinkle E, Vasan RS. The association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the CHARGE Consortium. Circ Cardiovasc Genet 2010;3:256-266. (PMC3025695)
7. AC Morrison, JF Felix, LA Cupples , NL Glazer, LR Loehr, A Dehghan, S Demissie, JC Bis, WD Rosamond, YS Aulchenko, YA Wang, T Haritunians, AR Folsom, F Rivadeneira, EJ Benjamin, T Lumley, D Couper, BH.Stricker, CJ O'Donnell, KM Rice, PP Chang, A Hofman, D Levy, JI Rotter, ER Fox , AG Uitterlinden, TJ Wang, BM Psaty, JT Willerson, CM van Duijn, E Boerwinkle, JCM Witteman, RS Vasan, NL Smith. Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the CHARGE Consortium. Circ Cardiovasc Genet 2010;3:248-255. (PMC3033765)
8. Smith NL, Rice KM, Bovill EG, Cushman M, Bis JC, McKnight B, Lumley T, Glazer NL, van Hylckama Vlieg A, Tang W, Dehghan A, Strachan DP, O’Donnell CJ, Rotter JI, Heckbert SR, Psaty BM, Rosendaal FR. Genetic variation associated with plasma von Willebrand factor levels and the risk of incident venous thrombosis. Blood 2011;117:6007-11. (PMC3112044)
9. Smith NL, Huffman JE, Strachan DP, [ … ], Soranzo N, Koenig W, Hayward C. Genetic predictors of fibrin D-dimer levels in healthy adults. Circulation 2011;123:1864-72. (PMC3095913)
10. Smith NL, Heit JA, Tang W, Teichert M, Chasman DI, Morange PE. Genetic variation in F3 (tissue factor) and the risk of incident venous thrombosis: meta-analysis of 8 studies. J Thromb Haemost 2012;10:719-22. (PMC3397243)
11. Smith NL, Blondon M, Wiggins KL, Harrington LB, van Hylckama Vlieg A, Floyd JS, Hwang M, Bis JC, McKnight B, Rice KM, Lumley T, Rosendaal FR, Heckbert SR, Psaty BM. Lower risk of cardiovascular events in postmenopausal women taking oral estradiol compared with oral conjugated equine estrogens. JAMA Intern Med. 2014;174:25-31. [PMC pending]
12. Goldberg J, Magruder KM, Forsberg CW, Kazis LE, Ustün TB, Friedman MJ, Litz BT, Vaccarino V, Heagerty PJ, Gleason TC, Huang GD, Smith NL. The association of PTSD with physical and mental health functioning and disability (VA Cooperative Study #569: the course and consequences of posttraumatic stress disorder in Vietnam-era Veteran twins). Qual Life Res. 2013 Dec 7. [Epub ahead of print] [PMC pending]
13. Blondon M, van Hylckama Vlieg A, Wiggins KL, Harrington LB, McKnight B, Rice KM, Rosendaal FR, Heckbert SR, Psaty BM, Smith NL. Differential associations of oral estradiol and conjugated equine estrogen with hemostatic biomarkers. J Thromb Haemost 2014.12:879-86. [PMC pending]
14. Vaccarino V, Goldberg J, Magruder KM, Forsberg CW, Friedman MJ, Litz BT, Heagerty PJ, Huang GD, Gleason TC, Smith NL. Posttraumatic stress disorder and incidence of type-2 diabetes: a prospective twin study. J Psychiatr Res. 2014 Sep;56:158-64.
15. Blondon M, Quon BS, Harrington LB, Bounameaux H, Smith NL. Association between newborn birthweight and the risk of postpartum maternal venous thromboembolism: a population-based case-control study. Circulation. 2015; in press.
16. Germain M, Chasman DI, de Haan H, […], Trégouët DA, Smith NL, Morange PE. Meta-analysis of 65,734 Individuals Identifies TSPAN15 and SLC44A2 as Two Susceptibility Loci for Venous Thromboembolism. Am J Hum Genet. 2015; in press.

In The News

Various Oral Estrogen Drugs May Differ in Cardiovascular Risk
HCP Live, 10/04/2013

Pfizer's Premarin for Menopause Linked to Blood Clot Risk
Bloomberg Businessweek, 09/30/2013

Less Blood Clot Risk Linked to Estradiol than Premarin Pills
JAMA Internal Medicine, 09/30/2013