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Center for Clinical and Epidemiological Center (CCER)

The Center for Clinical and Epidemiological Research (CCER) at the University of Washington is an interdisciplinary group of researchers and clinicians who are devoted to understanding and promoting quality healthcare in underserved populations. CCER's research programs are varied and inclusive, focusing on diverse populations as well as innovative research strategies. The CCER is now under the Department of Epidemiology, School of Public Health.

The UW Twin Registry

The University of Washington (UW) Twin Registry is a database, supported by the National Institutes of Health, to help scientists better understand what makes people healthy as well as what causes disease. Information is collected from participants in order to learn more about health and illness.

Since some health conditions are rare in the community, a large number of twin pairs are necessary to conduct health research. A number of countries around the world, including Australia, Belgium, England, Finland, the Netherlands, Norway, and the United States, have created large databases of twins. These registries have been used to uncover clues to the origins of many diseases such as depression, alcoholism, Parkinson's disease, and Alzheimer's disease. Surprisingly, however, there is only a handful of twin registries in the United States. This has made it difficult for scientists here to conduct important twin research.

The University of Washington Twin Registry is unique for two reasons. First, we invite twin pairs who live in Washington State to participate as well as twins from other parts of the United States and the world. Thus, the Registry has the potential to involve thousands of twins. Second, the University of Washington Twin Registry is drawn from the community at large and not just from clinics or hospitals where most research is done. Therefore, the Registry will be an invaluable scientific resource that will ultimately help to reduce the burden of illness in the population as a whole

Chronic Pain and Chronic Fatigue

Chronically fatiguing conditions such as chronic fatigue syndrome and fibromyalgia are longstanding and debilitating health conditions of unknown cause. While these conditions have been associated with major depression and other psychiatric diagnoses, perturbations of the hypothalamic-pituitary-adrenal axis, disruption of sleep architecture, and neurocognitive impairment, these abnormalities are typically subtle, and their role in the conditions not known.

The chronic fatigue and pain research program at the UW CCER evolved out of the Chronic Fatigue Clinic at Harborview Medical Center in Seattle, Washington. The Clinic, which opened in 1988, is directed by Dr. Dedra Buchwald, an internist and leading researcher in the area of chronic fatigue syndrome. The Clinic was one of the first tertiary care clinics in the country focused on the assessment and treatment of chronically fatiguing conditions.

The research program that has grown out of this clinical effort has focused on illuminating the "5 P's" model of chronically fatiguing conditions: predisposition, precipitants, perpetuators, predictors of chronicity, and perceptual factors involved in the illness. In 1994 Dr. Buchwald and an interdisciplinary group of collaborators were awarded one of three Chronic Fatigue Syndrome Cooperative Research Center grants from the National Institutes of Health. The original Cooperative Research Center involved three cores to support a research effort and four specific research projects. The Cooperative Research Center was renewed in 1999 to support the three cores and pursue an additional four projects.

More recently, the program has also focused on examining the effectiveness of several unique treatments.

Partnership for Native Health

The mission of the Partnership for Native Health is to develop practical preventive health interventions, together with tribal communities, to determine and solve their own unique health challenges.

For more than a decade, researchers at CCER have been involved in studies of American Indian and Alaska Native health issues including cancer prevention, treatment and survivorship, exercise, organ donation, understanding numeracy, and a wide variety of other factors that affect the health and well-being of American Indians and Alaska Natives. Our programs focus on research, training, continuing education, technical assistance, and dissemination of information in a way that recognize the unique cultural contexts of American Indian and Alaska Native people.

Center for Clinical & Epidemiological Research
Box 357236
1730 Minor Avenue, Suite 1760
Seattle, WA 98101

Phone: (206) 543-3717, (888) 223-0868
Fax: (206) 543-3830
Email: ccerexe@uw.edu

Website: http://depts.washington.edu/uwccer/




This page was last updated on January 15, 2013