Gale Lab

University of Washington | Department of Immunology

  Research in the Gale Laboratory is focused on understanding innate immunity to virus infection, the intracellular immune process and virus-host interactions that govern the viral replication and infection outcome. In addition to studying West Nile virus and human immunodeficiency virus, the laboratory is a component of the Hepatitis C virus Cooperative Research Centers supported by the NIH.  


CIIID Scholars Summer Internship Application now available!

The Gale Lab welcomes new postdoc Dr. Jennfier Stencel-Baerenwald!

The UW announces new Center for Innate Immunity and Immune Disease (CIIID)

Dr. Kwan Chow awarded
Croucher Foundation Fellowship for Postdoctoral Research

Gale Lab awarded renewal of Center for the Study of Immune Control of Flavivirus Infection

Gale Lab Awarded Three Year Contract for Adjuvant Development

CDC Announces Expanded Hepatitis C Testing Recommendations

Gale Lab publishes results that could lead to new drug therapies.

Research Centers

Center for the Study of Immune Mechanisms of Flavivirus Control

Innate Immune Antivirals for Biodefense

Center for the Study of Innate Immunity to Hepatitis C Virus

Systems Immunogenetics of Biodefense Pathogens in the Collaborative Cross

Center for Innate Immunity and Immune Disease

Research Programs

The Host Response to Hepatitis C Virus

The Host Response to West Nile Virus

Innate Immune Regulation of Human Immunodeficiency Virus

Virus-Host Interactions

Host Defense

Drug Development and Vaccines

Innate Immune Adjuvant Discovery

Anti-viral Discovery

Adjuvant Development


Hepatitis C Virus

West Nile Virus

Human Immunodeficiency Virus


Recent Publications

Kell, A.M., Gale, M.Jr. (2015) RIG-I in RNA virus recognition. Mar 4. pii: S0042-6822(15)00063-X. PMID: 25749629

Horner, S.M., Wilkins, C., Badil, S., Iskarpatyoti, J., Gale, M. Jr. (2015) Proteomic Analysis of Mitochondrial-Associated ER Membranes (MAM) during RNA Virus Infection Reveals Dynamic Changes in Protein and Organelle Trafficking. 10(3):e0117963. PMID: 25734423 PMCID: PMC4348417

Errett, J.S., Suthar, M.S., McMillan, A., Diamond, M.S., Gale, M. Jr. (2013) The essential, non-redundant roles of RIG-I and MDA5 in detecting and controlling West Nile virus infection. J Virol. IN PRESS. PMID: 23966395

Horner, S.M., Gale, M. Jr. (2013) Regulation of hepatic innate immunity by hepatitis C virus. Nat Med. 19(7): 879-888. PMID: 23836238

Negash, A.A., Ramos, H.J., Crochet, N., Lau, D.T., Doehle, B., Papic, N., Delker, D.A., Jo, J., Bertoletti, A., Hagedorn, C.H., Gale, M. Jr. (2013) IL-1β production through the NLRP2 inflammasome by hepatic macrophages links hepatitis C virus infection with liver inflammation and disease. PLoS Pathog. 9(4):e1003330. PMID: 23633957 PMCID: PMC3635973

Ramos, H.J., Lanteri, M.C., Blahnik, G., Negash, A., Suthar, M.S., Brassil, M.M., Sodhi, K., Treuting, P.M., Busch, M.P., Norris, P.J., Gale, M. Jr. (2012) IL-1B Signaling Promotes CNS-Intrinsic Immune Control of West Nile Virus Infection. PLoS Pathog. 8:e1003039. PMID: 23209411 PMCID: PMC3510243

Wilkins, C., Woodward, J., Lau, D.T., Barnes, A., Joyce, M., McFarlane, N., Tyrrell, D.L., Gale, M. Jr. (2012) IFITM1 is a tight junction protein that inhibits hepatitis C virus entry. Hepatology. 57(2): 461-469. PMID: 22996292 PMCID: PMC3566288

More Publications from the Gale Lab