|The Center for the Study of Immune Mechanisms of Flavivirus Control is supported by the NIH and is comprised of five projects and two Cores, integrated into a Program of study aimed at defining the immune mechanisms that control West Nile virus infection. These unique projects feature comparative analyses of the emergent, virulent strain of WNV and a non-emergent, avirulent WNV strain. Results from these studies are providing novel insights to guide vaccine and therapeutic strategies aimed at modulating flavivirus infection.
Dr. Michael Gale, Jr. and Dr. Michael Diamond
This project aims to define the viral and host genetic determinants, and the cell-specific pathways, that control alpha/beta interferon innate immune defenses against infection
Dr. Edward Clark
This project is focused on understanding the interactions of WNV, innate immune programs and dendritic cells (DCs), that govern DC function and regulate B cell production of an effective antibody response against infection.
Dr. Murali Krishna-Kaja
This project aims to determine the role of alpha/beta interferon in regulating T cell activation and effector function against WNV
Dr. Michael Bevan
This project is designed to determine the role of CD8 T cells and the parameters of an effective CD8 response in controlling WNV infection.
Dr. Jennifer Lund
This project is focused on defining the role of T regulatory cells in WNV infection and immunity.
Administrative and Virology Cores:
Management and research infrastructure support for the Program will be respectively conducted through an Administrative Core and a Virology Core.
Program Manager and Center Administrator
Dr. Yueh-Ming Loo
Director, Virology Core