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Innate Immune Effector Genes Innate immune signaling and the actions of alpha/beta interferons The Gale laboratory is engaged in ongoing studies to define the molecular mechanisms of innate immune signaling actions of RIG-I, MDA5, and other PRR pathways that regulate immunity against RNA virus infection. These studies include a specific focus to define the interferon-stimulated genes and their actions in innate immune programs in vivo within gene knockout mouse models. |
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