Daniel G. Miller, MD, PhD

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Associate Professor, Pediatrics

Clinical Genetics;
Director, Miller Lab

University of Washington
Box 358056
Seattle, WA 98195-8056
Phone: 206 685-3882
Email: dgmiller@uw.edu
Seattle Children's Profile

Research interests: Facioscapulohumeral Muscular Dystrophy, Gene Targeting for the treatment of Dominantly Inherited Diseases

Daniel G. Miller, MD, PhD, is an Associate professor at Seattle Children’s Hospital and the University of Washington School of Medicine. Miller’s Laboratory is located in the Institute for Stem Cell and Regenerative Medicine at the University of Washington’s South Lake Union Research facility.

He is interested in the molecular pathophysiology of Facioscapulohumeral Muscular Dystrophy and collaborates with a group of Scientists located around the world to perform studies that will determine the molecular events that cause muscle weakness in this dominantly inherited adult-onset disease. Miller also uses gene therapy strategies to study and treat human genetic diseases. He constructs vectors based on retroviruses that deliver an entire copy of the gene to patient cells for “gene replacement” therapies, and vectors based on adeno-associated virus (AAV) that pair with chromosomal sequences facilitating “gene repair” by homologous recombination. Using these techniques, he is able to modify primary human cell lines to repair of specific mutations that cause human diseases, or generate mutations similar to those causing inherited disease in patients to study the cellular effects of such mutations. Miller sees patients with genetic conditions in the Medical Genetics Clinic.