William B. Dobyns, MD

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Professor

Center for Integrative Brain Research

University of Washington
Box 356320
Seattle, WA 98195-6320
Phone: 206 884-1025
Email: wbd@uw.edu
Seattle Children's Profile

Dr. Dobyns leads a broad-based research program investigating the nature and causes of a wide range of human developmental brain disorders. These include malformations of the forebrain, mid-hindbrain (brainstem and cerebellum) and cerebral cortex, as well as a wide spectrum of developmental disabilities including autism, intellectual disability, early childhood "developmental" forms of epilepsy, and complex developmental disorders combining several of the above. His work includes recognition and delineation of specific conditions, identification of numerous underlying genes, and detailed phenotype and genotype-phenotype analysis. The methods used in his lab include most standard molecular genetics methods plus fluorescence in situ hybridization, chromosome microarrays (comparative genome hybridization), RNA expression arrays, methylation-sensitive assays for X inactivation, standard (Sanger) sequencing, and most recently high-throughput exome sequencing.