Syllabus |
Lecture: Monday-Thursday, 10:50-11:50, Anderson 223
Discussion Sections: Tuesday and Thursday, 1:10-2:10 and 2:20-3:20, HSB J-280
Textbook (required):Genetics: From Genes to Genomes, 1st edition, Hartwell et al (with accompanying CD-ROM)
Student Guide(recommended): Solutions Manual / Study Guide, 1st edition, Reynolds
Instructors: | Robert Choy 616-6774 office hours: Tuesday, 4:00-5:00 HSB J-182 |
Ann Reynolds 616-6774 office hours: Thursday, 9:00-10:00 HSB J-215 |
TA: | Heidi Parker 667-6980 office hours: Mon 1:00-2:00 HSB K-121 |
Grading:
Total: 400 points
3 exams: 100 points each
3 problem sets: 20 points each
2 ethics essays: 20 points each
Websites:
Genetics: From Genes to Genomes
Ethics Essays: (papers due on Mondays, see dates below)
For two of the ethical/social issues listed below, write a brief response (about one page) to the problem in which you do the following: First, briefly summarize the scientific context of the problem. Then pick two people or organizations who are stakeholders in the issue (stakeholders are persons who are directly impacted or stand to gain or lose by the outcome of the situation). For these two stakeholders, describe the stance you think that person would take and why they would take that position (note that you will not necessarily be answering the questions posed at the end of each issue for this exercise).
One Ethics Problem must be chosen from this group:
Week 2 pg 32; issue 2 Due: June 26
Week 3 pg 99; issue 1 Due July 3
Week 4 pg 135; issue 1 Due: July 10
Week 5 pg 299; issue 3 Due: July 17
One Ethics Problem must be chosen from this group:
Week 6 pg 452; issue 1 Due: July 24
Week 7 pg 552; issue 1 Due: July 31
Week 8 pg 618; issue 2 Due: August 7
Week 9 pg 777; issue 3 Due: August 14
Date | Lecture | Reading | |
June | 19 | Monohybrid; Human Inheritance | 10-18; 25-29 |
20 | Testcross; Dihybrid; Probability | 18-25; CD: Genetic Diversity Animation Chromosome Alignment Interactives | |
21 | Incomplete Dominance; Multiple Alleles | 38-49 | |
22 | Epistasis; Complementation | 49-63 | |
26 | Chromosome Theory; Sex Linkage | 70-76; 91-98 | |
27 | Linkage I | 105-118 | |
28 | Linkage II: Two and Three Factor Crosses | 118-125; CD: Physical Distances, Making a Map | |
29 | Linkage III: Maps; Tetrads; PROBLEM SET 1 DUE | 125-134 | |
July | 3 | DNA Structure; Restriction Enzymes | 150-156; 262-268; CD: Restriction Enzymes |
4 | HOLIDAY | ||
5 | Cloning; Hybridization; PCR | 268-272; 277-279; 287-293; CD: PCR; Probes | |
6 | EXAM 1 | ||
10 | Mutations; Gene Function | 201-213 | |
11 | Direct Detection of Genotype-RFLP | 308-320; CD: Markers: Make a Map | |
12 | Direct Detection of Genotype - Uses | 326-333 | |
13 | Genome Analysis; Positional Cloning | 341-347; 351-365; CD: Map a Gene | |
17 | Genome Analysis: Complex Traits | 371-378; CD: QTL Analysis | |
18 | Genome Analysis; Genetic Analysis | 632-636 | |
19 | Mouse Genetic Analysis | 742-748 | |
20 | Non-Mendelian Inheritance | 501-515 | |
24 | Chromosome Structure | 390-413 | |
25 | Chromosome Rearrangements; PROBLEM SET 2 DUE | 419-452 | |
26 | Mutations; DNA Repair; Ames test | 179-193 | |
27 | Prokaryotic Gene Regulation | 530-540; CD: Lactose Operon | |
31 | EXAM 2 | ||
August | 1 | Eukaryotic Gene Regulation | 558-577; CD: Transcription Factors |
2 | Yeast Cell Cycle Genetics | 590-599 | |
3 | Oncogenes | 600-618 | |
7 | Tumor Suppressors | 600-618 | |
8 | Population Genetics 1 | 754-759 | |
9 | Population Genetics 2; PROBLEM SET 3 DUE | 759-765; 769-776; CD: Allele frequencies | |
10 | Gene Therapy | E6-7 | |
14 | Behavioral Genetics | ||
15 | Drosophila Developmental Genetics | 714-725 | |
16 | C. elegans Neurogenetics | 681-691 | |
17 | EXAM 3 |