Syllabus

Lecture: Monday-Thursday, 10:50-11:50, Anderson 223

Discussion Sections: Tuesday and Thursday, 1:10-2:10 and 2:20-3:20, HSB J-280

Textbook (required):Genetics: From Genes to Genomes, 1st edition, Hartwell et al (with accompanying CD-ROM)

Student Guide(recommended): Solutions Manual / Study Guide, 1st edition, Reynolds

Instructors:

Robert Choy 616-6774

rchoy@genetics.washington.edu

office hours: Tuesday, 4:00-5:00 HSB J-182

Ann Reynolds 616-6774

annreyn@u.washington.edu

office hours: Thursday, 9:00-10:00 HSB J-215

TA:

Heidi Parker 667-6980

hgparker@fhcrc.org

office hours: Mon 1:00-2:00 HSB K-121

Grading:

Total: 400 points

3 exams: 100 points each

3 problem sets: 20 points each

2 ethics essays: 20 points each

Websites:

Genetics: From Genes to Genomes

Ethics Essays: (papers due on Mondays, see dates below)

For two of the ethical/social issues listed below, write a brief response (about one page) to the problem in which you do the following: First, briefly summarize the scientific context of the problem. Then pick two people or organizations who are stakeholders in the issue (stakeholders are persons who are directly impacted or stand to gain or lose by the outcome of the situation). For these two stakeholders, describe the stance you think that person would take and why they would take that position (note that you will not necessarily be answering the questions posed at the end of each issue for this exercise).

One Ethics Problem must be chosen from this group:

Week 2 pg 32; issue 2 Due: June 26

Week 3 pg 99; issue 1 Due July 3

Week 4 pg 135; issue 1 Due: July 10

Week 5 pg 299; issue 3 Due: July 17

One Ethics Problem must be chosen from this group:

Week 6 pg 452; issue 1 Due: July 24

Week 7 pg 552; issue 1 Due: July 31

Week 8 pg 618; issue 2 Due: August 7

Week 9 pg 777; issue 3 Due: August 14

Date Lecture Reading
June 19 Monohybrid; Human Inheritance 10-18; 25-29
20 Testcross; Dihybrid; Probability 18-25; CD: Genetic Diversity Animation Chromosome Alignment Interactives
21 Incomplete Dominance; Multiple Alleles 38-49
22 Epistasis; Complementation 49-63
26 Chromosome Theory; Sex Linkage 70-76; 91-98
27 Linkage I 105-118
28 Linkage II: Two and Three Factor Crosses 118-125; CD: Physical Distances, Making a Map
29 Linkage III: Maps; Tetrads; PROBLEM SET 1 DUE 125-134
July 3 DNA Structure; Restriction Enzymes 150-156; 262-268; CD: Restriction Enzymes
4 HOLIDAY
5 Cloning; Hybridization; PCR 268-272; 277-279; 287-293; CD: PCR; Probes
6 EXAM 1
10 Mutations; Gene Function 201-213
11 Direct Detection of Genotype-RFLP 308-320; CD: Markers: Make a Map
12 Direct Detection of Genotype - Uses 326-333
13 Genome Analysis; Positional Cloning 341-347; 351-365; CD: Map a Gene
17 Genome Analysis: Complex Traits 371-378; CD: QTL Analysis
18 Genome Analysis; Genetic Analysis 632-636
19 Mouse Genetic Analysis 742-748
20 Non-Mendelian Inheritance 501-515
24 Chromosome Structure 390-413
25 Chromosome Rearrangements; PROBLEM SET 2 DUE 419-452
26 Mutations; DNA Repair; Ames test 179-193
27 Prokaryotic Gene Regulation 530-540; CD: Lactose Operon
31 EXAM 2
August 1 Eukaryotic Gene Regulation 558-577; CD: Transcription Factors
2 Yeast Cell Cycle Genetics 590-599
3 Oncogenes 600-618
7 Tumor Suppressors 600-618
8 Population Genetics 1 754-759
9 Population Genetics 2; PROBLEM SET 3 DUE 759-765; 769-776; CD: Allele frequencies
10 Gene Therapy E6-7
14 Behavioral Genetics
15 Drosophila Developmental Genetics 714-725
16 C. elegans Neurogenetics 681-691
17 EXAM 3

return to main page