Genetics 372, Winter 1999

March 1  READINGS AND STUDY QUESTIONS

Reading R10 and Study Questions K were assigned last week. However, you are NOT RESPONSIBLE for question K.16.

Study Questions L are assigned after tomorrow's class (Tuesday, Mar 2). However, you are NOT RESPONSIBLE for question L.6.

The LAST READING, R11, on a human mutation affecting hand development, is assigned after Wednesday's class (Mar 3).

February 19 READING R9 Correction

Reading R9, which is assigned reading on Monday, Feb. 22, has an error. On page 5, left column, near the bottom, the large type that says.....

"(Note that in Figure 4 at position -34 the arrow should point downward, T -> C.)"

.....should not be there. The Legend to Figure 4 is correct. The upward arrow at position -34 means that the mutation results in a small increase in promoter activity.

February 19     GRADED EXAMS/DROP DEADLINE

As announced in class on Wednesday, graded Exams 2 and Keys are available in the Genetics office, J-205.
This Sunday, February 21, is the last day that a class can be dropped.

WEEK OF FEBRUARY 8

 Second Exam:  Friday, February 12, 11:30-1:20
 (calculators with one-line screens--OK)
RESPONSIBILITY: 
Class Notes through Section 22.3
Readings R3, R4, R5, R6 & R7 
Study Questions D, E, F & G
LOCATION: HOGNESS AUDITORIUM
                  A-Wing, Health Sciences Center
Quiz Sections & Office Hours: 
   QUIZ SECTIONS:  usual times
   OFFICE HOURS (*extra):	
Monday	Karen James,  10:00-11:00,  J-279
Tuesday	Walt Fangman,  12:35-1:35,  J-182      Karen James,  4:30-5:30,  J-112
Wednesday	Walt Fangman,  (*)12:35-1:35,   J-182    Michael McMurray,  2:30-3:30,   J-112
Thursday	Michael McMurray,  (*)2:30-3:30,  J-112
Friday	CANCELED
Lecture Question/Answer Session: 
Thursday	Walt Fangman,  4:00 - 5:00,  J-279 HSC




January 29

(1). Study Question D.1 ANSWER.  The final product of the ligation is not
typed correctly, it should be:

5' GAATTCC-----------GGAATTC 3'
3' CTTAAGG-----------CCTTAAG 5'


(2). Lecture Notes page 43, Left Panel.  In Book 1 the spacing of letters
for item C is a bit strange and might be misread.  The phrase reads:

C. Comparison  of  cDNA  and  Genomic  DNA

(Note: "genomic DNA" refers to total (nuclear) DNA isolated directly from
cells of the organism.  "Genomic clone" refers to a piece of cloned DNA
isolated from a library made from an organism's total DNA, i.e., from a
genomic library).


(3). Lecture Notes page 44, Left Panel.  The Conclusion at the bottom
should read:

Conclusion:  INTRON information is present in the nuclear transcript and is
spliced out to make the mRNA.


(4). Reading R3. Page 3, 1st column, end of first paragraph. The sentence should end as follows: 

". . . . . skipping of exon 44, where the donor site of 
intron 43 is now joined to the acceptor site of intron 
44." (NOT intron 45).



January 15, 1998

REMINDER:  Courses must be dropped by Sunday, January 17.

                    WEEK OF JANUARY 18

Monday, January 18 is a holiday!

First Exam:   Friday,  January 22, 11:30-1:20
               (calculators with one-line screens--OK)

   RESPONSIBILITY: Class Notes through Section 11.2 
                     Readings R1 & R2  
                     Study Questions P, A, B & C (including the A.1 
                                        DNA Structure web exercise)

   LOCATION: HOGNESS AUDITORIUM
             A-Wing Health Sciences Center

Quiz Sections & Office Hours: 
    QUIZ SECTIONS: Usual times

     OFFICE HOURS:  Some time changes & extra hours (in bold)
          Karen James      Monday canceled
          Walt Fangman     J-182 HSC 12:35-1:30 Tuesday 
                                    & (extra) Wednesday 
          Karen James      J-112 HSC  4:30-5:30 Tuesday
          Michael McMurray J-182 HSC  2:30-3:30 Wednesday
          Karen James      J-112 HSC  9:30-10:30 Thursday (extra)
          Michael McMurray J-112 HSC  2:30-3:30 Thursday (extra)
          NO OFFICE HOURS FRIDAY

Lecture Question/Answer Session: 
          Walt Fangman     J-280 HSC  4:00-5:00 Thursday

January 11, 1999

Chi Squared Test

The description of the Chi Squared satatistical test in Reading R2 is not clear and does not follow common usage. A handout will be provided at class tomorrow (Tuesday, 1/12) which gives the Chi Square description from the earlier edition of "Introduction to Genetic Analysis". The description in the handout of degrees of freedom (df) is simpler, is the more commonly used one, and is the one used in the Study Questions. The value for df is taken as the number of classes of data minus 1. For the example in the reading of testing for independent assortment the number of classes is four (AB, ab, Ab, aB) and df = 3.

January 7,
1999

ROOMS AND TIMES: OFFICE HOURS AND QUIZE SECTIONS -- UPDATE
		_____________________________________________
                      Office Hours
        Monday    Karen James
                   10:00-11:00
                   J-279 HSC

        Tuesday   Walt Fangman     Karen James
                    12:30-1:30       4:30-5:30
                    J-182 HSC        J-112 HSC

        Wednesda  Michael McMurray	
                    2:30-3:30
                    J-112 HSC

        Thursday   ------------

        Friday     Michael McMurray  Walt Fangman
                    10:20-11:20       12:30-1:30
                    J-182 HSC         J-182 HSC
		_______________________________________________
		_______________________________________________
                  Quiz Sections 1:30-2:20

        Tuesday    Section A      Section C
                    Karen James     Michael McMurray
                    J-280 HSC       Hitchcock 132

        Wednesday  Section D      Section B
                    Karen James     Michael McMurray
                    Hitchcock 324   J-280 HSC
		_______________________________________________