Assigned Readings

R1 DNA Structure and Properties
• Chapter 10, pp. 274-293 , William Klug and Michael Cummings, "Concepts of Genetics." 45h ed., Prentice-Hall, Inc., 1997

R2 Mapping by Meiotic Recombination
• Chapter 5, pp. 123-144 , Griffiths and others,"Introduction to Genetic Analysis." 6th ed., W. H. Freeman Co., 1996.

R3 Cloning Bacterial Genes by Complementation
• Adapted from Stanley Bower and others, "Cloning, sequencing, and characterization of the Bacillus subtilis biotin biosynthetic operon." J. Bacteriology vol. 178 (1996) pages 4122- 4130.

R4 Bacterial Virus Genetics
• Walton L. Fangman, "Complementation and intragenic recombination with a bacterial virus."

R5 Mutations in a Human Gene Resulting in Stops, Frameshifts and a Splicing Defect
• Adapted from Anna Maria Barbieri and others, "Seven novel additional small mutations and a new alternative splicing in the human dystrophin gene ......" Eur. J. Human Genet. vol. 4 (1996) pages 183-187.

R6 Meiotic Linkage Analysis with Human Pedigrees
• Natalie Angier, "Scientists zero in on gene tied to prostate cancer." The New York Times, November 22, 1996.
• Walton L. Fangman and Katherine Kolor, "Quantitative analysis of linkage with human pedigrees."

R7 Cloning and Sequence Analysis of a Human Disease Gene
• Adapted from Toshio Mochizuki and others, "PDK2, a gene for polycystic kidney disease that encodes an integral membrane protein." Science vol. 272 (1996) pages 1339-1342.

R8 Mitochondrial DNA Inheritance
• An article relevant to this topic will be handed-out if an appropriate one is found.

R9 Analysis of a Bacterial Promoter
• Adapted from Teresa J. Kenny and Gordon Churchward, "Genetic analysis of theMycobacterium smegmatis rpsL promoter." J. Bacteriology vol. 178 (1996) pages 3564- 3571.

R10 Regulation of a Bacterial Gene
• Adapted from Frieder Schock and Michael Dahl, "Expression of the tre operon of Bacillus subtilis 168 is regulated by the repressor TreR." J. Bacteriology vol. 178 (1996) pages 4576-4581.

R11 Mutations Causing Defects in Human Development
• Adapted from Yatsuteru Muragaki and others, "Altered growth and branching patterns in synpolydactyly caused by mutations in HOXD13." Science vol. 272 (1996) pages 548-551.