Genetics 372 Winter 2000
R1: DNA Structure and Properties
· Chapter 10, pp. 274-293 , William Klug and Michael
Cummings, "Concepts of Genetics." 5th ed., Prentice-Hall,
Inc., 1997
R2: Cloning a Human Gene by Complementing a Yeast Mutation
· Adapted from Ravi Amaravadi and others, "Isolation
of a cDNA encoding the human homolog of COX17, a yeast gene essential
for mitochondrial copper recruitment." Human Genetics, Vol.
9 (1997) pages 329-333
R3: Bacterial Virus Genetics
· Walton L. Fangman,"Complementation and intragenic
recombination with a bacterial virus."
R4: A STOP Mutation in a Human "Disease" Gene
· Adapted from Linda C. Walker and others, "A
Patient with Ehlers-Danlos Syndrome Type VI is Homozygous for
a Premature Termination Codon in Exon 14 of the Lysyl Hydroxylase
1 Gene." Molecular Genetics and Metabolism, Vol. 67 (1999)
pages 74-82.
R5: Mapping by Meiotic Recombination
· Chapter 5, pp. 118-135 , Griffiths and others,"Introduction
to Genetic Analysis." 5th ed., W. H. Freeman Co., 1993.
R6: Meiotic Linkage Analysis with Human Pedigrees
· Natalie Angier, "Scientists zero in on gene
tied to prostate cancer." The New York Times, November 22,
1996.
· Walton L. Fangman and Katherine Kolor, "Quantitative
analysis of linkage with human pedigrees."
R7: Fruit Fly "Model" of a Human Disease
· Adapted from Kyung-Tai Min and Seymour Benzer, "Preventing
Neurodegeneration in the Drosophila Mutant bubblegum." Science,
Vol. 284 (1999) pages 1985-1988.
R8: Screening and Counseling a Family with Inherited Breast
Cancer
· Adapted from Barbara B. Biesecker and others, "Genetic
Counseling for Families With Inherited Susceptibility to Breast
and Ovarian Cancer" Journal of the American Medical Association,
Vol. 269 (1993) pages 1970-1974.
R9: Mitochondrial DNA Inheritance
· To be assigned.
R10: Regulation of a Bacterial Gene
· Adapted from Frieder Schock and Michael Dahl, "Expression
of the tre operon of Bacillus subtilis 168 is regulated by the
repressor TreR." J. Bacteriology, Vol. 178 (1996) pages 4576-4581.
R11: Mutations Causing Defects in Human Development
· Adapted from Yatsuteru Muragaki and others, "Altered
growth and branching patterns in synpolydactyly caused by mutations
in HOXD13." Science, Vol. 272 (1996) pages 548-551.
R12: A Defect in Replicating Damaged DNA in an Inherited
Skin Cancer
· Adapted from Robert E. Johnson and others, "hRAD30
Mutations in the Variant Form of Xeroderma Pigmentosum" Science,
Vol. 285 (1999) pages 263-265.