Genetics 570

Phylogenetic Inference

Spring, 2000

Joe Felsenstein

Syllabus of lectures

Date

Topic

Reading

            
3/27What is a phylogeny? Parsimony - a small exampleChapter 1
29Parsimony algorithms - small parsimony problemChapter 2
31Exact enumeration - the number of treesChapter 3
            
4/3Searching tree space heuristicallyChapter 4
5Branch and boundChapter 5
7Reconstruction of ancestral character states. Branch lengthsChapter 6
            
4/10Variants of parsimonyChapter 7
12CompatibilityChapter 8
14Inconsistency and parsimonyChapter 9
            
4/17A brief discussion of philosophy, parsimony, history etc.Chapter 10
19Distance matrix methods: UPGMA, Fitch-MargoliashChapter 11
21        "        "        "    : Neighbor-joining, Minimum evolution, etc.Chapter 11
            
4/24DNA distances incl. rate variation among sites,Chapter 13
26Protein distances and models, Restriction sites and RAPDChaps. 14, 15
28Guest lecture (Richard Olmstead, Botany Dept.)    
            
5/1Guest lecture (Scott Edwards, Zoology Dept.)    
3Microsatellite distances and modelsChapter 15
5Likelihood methodsChapter 16
            
5/8" "Chapter 16
10Testing trees, clocks, etc. by likelihood ratio testsChapter 17
12The bootstrap, the jackknife, etc.Chapter 18
            
5/15The KHT test(s)    
17Invariants ("evolutionary parsimony")Chapter 20
19Trees from continuous characters and gene frequenciesChaps. 21, 22
            
5/22Comparative methods    
24Other kinds of trees: CoalescentsChapter 24
26Likelihoods on coalescentsChapter 25
            
5/29HOLIDAY (Memorial Day; last day of Folk Life Festival)    
31Tree distances. Consensus treesChapter 28
6/2Tests based on tree shape. Drawing rooted and unrooted trees    

Final Exam:

2:30-4:30 Wednesday, June 7 in J280 HSB

Textbook:

Felsenstein, J. 2000. Inferring Phylogenies. ASUW Publishing, Seattle. (available at their office in HUB 113, price about $20).