Genetics 570

Phylogenetic Inference

Spring, 2002

Joe Felsenstein

Syllabus of lectures

Date

Topic

Reading

     
4/1 What is a phylogeny? Parsimony - a small example Chapter 1
  3 Parsimony algorithms - small parsimony problem Chapter 2
  5 Exact enumeration - the number of trees Chapter 3
     
4/8 Searching tree space heuristically Chapter 4
  10 Branch and bound Chapter 5
  12 Reconstruction of ancestral character states. Branch lengths Chapter 6
     
4/15 Variants of parsimony Chapter 7
  17 Compatibility Chapter 8
  19 Inconsistency and parsimony Chapter 9
     
4/22    "   "   "   "  "  
  24 A brief discussion of philosophy, parsimony, history etc. Chapter 10
  26 Distance matrix methods: UPGMA, Fitch-Margoliash Chapter 11
     
4/29      "    "      "    : Neighbor-joining, Minimum evolution, etc. Chapter 11
5/1 DNA distances incl. rate variation among sites, Chapter 13
  3 Protein distances and models Chapter 14
     
5/6 Restriction sites, RAPDs, microsatellites, etc. Chaps. 14, 15
  8 Likelihood methods Chapter 16
  10 Bayesian inference Chapter 18
     
5/13 Testing trees, clocks, etc. by likelihood ratio tests Chapter 19
  15 The bootstrap, the jackknife, etc. Chapter 20
  17    "   "   "      "   "   
     
5/20 The KHT test(s) Chapter 21
  20 Invariants ("evolutionary parsimony") Chapter 22
  22 Trees from continuous characters and gene frequencies Chaps. 23, 24
     
5/27 HOLIDAY (Memorial Day; last day of NW Folk Life Festival)  
  29 Comparative methods Chapter 25
  31 Another kind of tree: Coalescents Chapter 26
     
6/3 Likelihoods on coalescents Chapter 27
  5 Consensus trees. Tree distances. Chapter 33
  7 Tests based on tree shape. Drawing rooted and unrooted trees Chaps. 33, 34

Final Exam:

2:30-4:30 Wednesday, June 12 in J280 HSB

Textbook:

Felsenstein, J. 2002. Inferring Phylogenies. To be reproduced at cost (about $20) and sold in class during the first week. Book will be published by Sinauer Associates, Sunderland Massachusetts, this summer.