Division of Gerontology and Geriatric Medicine -abrassc

Division of Gerontology and Geriatric Medicine

CHRISTINE K ABRASS MD FACP
Professor
Department of Medicine
Division of Gerontology and Geriatric Medicine

VAPSHCS
1660 S Columbian Way
Seattle WA 98108

Phone: (206) 764-2002
Fax: (206) 764-2022
Email: cabrass@u.washington.edu

Licensure and Certification

Licensure	State of Washington
Board Certification:
1976	Certified, American Board of Internal Medicine
1980	Certified, Subspecialty of Nephrology

Education

1965-1969	BS-Denison University, Grandville OH
1969-1973	MD-Case Western Reserve University, Cleveland OH

Training

1973-1975	Internship and Residency in Internal Medicine University Hospital, University of California at San Diego CA
1975-1976	Residency in Internal Medicine Mercy Hospital and Medical Center, San Diego CA
07/1976- 06/1979	Fellow Division of Nephrology and Hypertension Harbor-University of California at Los Angeles Medical Center, Torrance CA

Positions

07/01/1978- 06/30/1984	Assistant Professor UCLA School of Medicine, Los Angeles CA
07/01/1984- 06/30/1992	Associate Professor University of Washington School of Medicine Department of Medicine, Seattle WA
07/01-1992- Present	Professor University of Washington School of Medicine Department of Medicine, Seattle WA

Honors

1976-1977 1977-1978	Research Fellowship Award, National Kidney Foundation
1979-1982	Teaching and Research Scholar, The American College of Physicians
1979	Distinguished Teaching Award, Harbor-UCLA Medical Center
1981	Fellow, American College of Physicians
1984	Membership, Western Association of Clinical Investigation
1987	Membership, American Society of Clinical Investigation
1988	Membership, Western Association of Physicians
1994	Attendee, American Association of Medical Colleges, Professional Development Seminar for Senior Women
1994	Science In Medicine Lecture, University of Washington
1998-1999	Fellow, Executive Leadership in Academic Medicine Program
1999	Mary Jane Kugel Award, Juvenile Diabetes Foundation, International
November 1999	Award for "Exceptional Leadership" from Women in Nephrology

Bibliography

	Papers
	Hansen KM, Abrass CK: Laminin-8/9 is synthesized by rat glomerular mesangial cells and is required for PDGF-induced mesangial cell migration, Kidney Int, 64:110-118, 2003. Berfield AK, Andress DL, Abrass CK: IGF-1-induced lipid accumulation impairs mesangial cell migration and contractile function, Kidney Int 62:1229-1237, 2002. Higaki Y, Schullery D, Kawata Y, Shnyreva M, Abrass C, Bomsztyk K: Synergistic activation of the rat laminin g1 gene by gut-enriched Kruppel-like factor (GKLF/KLF4) and Sp1, Nucleic Acids Res, 30:2270-2279, 2002. Kawata Y, Suzuki H, Higaki Y, Denisenko O, Schullery D, Hua X, Abrass C, Bomsztyk K: bcn-1-element-dependent activation of the laminin g1 chain gene promoter by the synergistic action of TFE3 and Smad proteins, J Biol Chem, 277:11375-84, 2002. Berfield AK, Abrass CK: IGF-1 induces foam cell formation in rat glomerular mesangial cells, J Histochem Cytochem 50:395-403, 2002. Ostrowski J, Kawata Y, Schullery DS, Denisenko ON, Higaki Y, Abrass CK, Bomsztyk K: Insulin alters heterogeneous nuclear ribonucleoprotein K protein binding to DNA and RNA. Proc Natl Acad Sci, 98:9044-9049, 2001. Abrass CK, Ballweg R, Gilshannon M, Coombs JB: A Process for Reducing Workload and Enhancing Residents' Education at an Academic Medical Center, Acad Med, 76:798-805, 2001. Peutz-Kootstra CJ, de Heer E, Hoedemaeker PhJ, Abrass CK, Bruijn JA: Lupus nephritis: Lessons from experimental animal models, J Lab Clin Med, 137:244-260, 2001. Abrass CK, Kimmel PL: Women and Renal Disease, Proceedings of an NIH Conference, http://www.niddk.nih.gov/fund/reports/womenrd/index.htm.-meetingrecommendations, 2001. Peutz-Kootstra CJ, Hansen K, de Heer E, Abrass CK, Bruijn JA: Differential expression of laminin chains and anti-laminin autoantibodies in experimental lupus nephritis, J Pathol, 192:404-412, 2000. Berfield AK, Andress DL, Abrass CK: IGFBP-5^201-218 stimulates Cdc42GAP aggregation and filopodia formation in migrating mesangial cells, Kidney Intern, 57:1991-2003, 2000. Abrass CK: Renal Biopsy in the Elderly. Am J Kidney Dis 35:544-546, 2000. Abrass CK: The nature of chronic progressive nephropathy in aging rats. Adv Renal Replace Ther 7:4-10, 2000 Hansen K, Abrass CK: Role of laminin isoforms in glomerular structure. Pathobiology, 67:84-91, 1999. Abrass CK, Berfield AK, Stehman-Breen C, Alpers CE, Davis CL: Unique changes in interstitial extracellular matrix composition are associated with rejection and cyclosporine toxicity in human renal allograft biopsies, Am J Kidney Dis, 33:11-20, 1999. Hansen K, Berfield AK, Spicer D, Abrass CK: Rat mesangial cells express two unique isoforms of laminin which modulate mesangial cell phenotype, Matrix Biol, 17:117-130, 1998. Abrass CK, Spicer D, Berfield AK, St. John PL, Abrahamson DR: Diabetes induces changes in glomerular development and laminin β2 (s-laminin) expression. Amer J Pathol, 151:1131-1140, 1997. Abrass CK, Berfield AK, Andress DL: Heparin binding domain of insulin-like growth factor binding protein-5 stimulates mesangial cell migration. Amer J Physiol 273 (Renal Physiol 42):F899-F906, 1997. Abrass CK: Clinical spectrum and complications of the nephrotic syndrome. J Investig Med 45:143-153, 1997. Berfield AK, Abrass CK: Insulin-like growth factor I (IGF I) induces unique effects in the cytoskeleton of cultured rat glomerular mesangial cells. J Histochem Cytochem 45:583-593, 1997. Hyink DP, Tucker DC, St. John PL, Leardkamolkarn V, Accavitti MA, Abrass CK, Abrahamson DR: Endogenous origin of glomerular endothelial and mesangial cells in grafts of embryonic kidneys. Am J Physiol 270:F886-F899, 1996. Berfield AK, Raugi GJ, Abrass CK: Insulin induces rapid and specific rearrangement of the cytoskeleton of rat mesangial cells in vitro. J Histochem Cytochem 42:91-101, 1996. Abrass CK: Diabetic nephropathy. Mechanisms of mesangial matrix expansion. West J Med 162:318-321,1995. Abrass, CK, Adcox MJ, Raugi GJ: Aging-associated changes in renal extracellular matrix. Am J Pathol. 146:742-752, 1995. Abrass CK: Diabetes mellitus: Can abnormally controlled would healing lead to glomerulosclerosis? J Lab Clin Med, 125:14-15, 1995. Abrass CK, Berfield AK: Phenotypic modulation of rat glomerular visceral epithelial cells by culture substratum. J Am Soc Nephrol 5:1591-1599, 1995. Abrass CK, Spicer D, Raugi GJ: Induction of nodular sclerosis by insulin in rat mesangial cells in vitro: Studies of collagen. Kidney Int 47:25-37, 1995. Abrass CK, Spicer D, Raugi GJ: Insulin induces a change in extracellular matrix glycoproteins synthesized by rat mesangial cells in culture. Kidney Int 46:613-620, 1994. Gauthier VJ, Abrass CK: Circulating immune complexes in renal injury. Semin Nephrol, 12:379-394, 1992. Abrass CK: Fc receptor‑mediated phagocytosis: Abnormalities associated with diabetes mellitus. Clin Immunol Immunopathol 58:1-17, 1991. Hori MT, Abrass CK: Isolation and characterization of circulating immune complexes from rats with Heymann nephritis. J Immunol 144:3849-3855, 1990. Abrass CK, Peterson CV, Raugi GJ: Phenotypic expression of collagen types in mesangial matrix of diabetic and non‑diabetic rats. Diabetes 37:1695-1702, 1988. Abrass CK, Raugi GJ, Gabourel L, Lovett DL: Insulin and insulin‑like growth factor‑I binding to cultured rat glomerular mesangial cells. Endocrinology 123:2432-2437, 1988. Abrass CK: Measurement of the rates of basal pinocytosis of horseradish peroxidase and internalization of heat‑aggregated IgG by macrophages from rats with streptozotocin‑induced diabetes. Immunology 65:411-415, 1988. Abrass CK, Cohen AH: Characterization of renal injury initiated by immunization of rats with heparan sulfate. Am J Path 130:103-111, 1988. Pillsworth TJ, Haver VM, Delaney CJ, Abrass CK: Differentiation of renal from non‑renal hematuria by microscopic examination of urine erythrocyte morphology. Clin Chem 10:1791-1795, 1987. Abrass CK, Cohen AH: Accelerated glomerulosclerosis in diabetic rats with immune complex injury. Diabetes 36:1246-1253, 1987. Abrass CK, Hori MT: Alterations in plasma clearance and tissue localization of model immune complexes in rats with streptozotocin‑induced diabetes. Immunology 60:331-336, 1987. Abrass CK, Laird CW: Tamm‑Horsfall protein coating of free cells in urine. Am J Kidney Dis 9:44-50, 1987. Abrass CK, Cohen AH: The role of circulating antigen in the formation of immune deposits in experimental membranous nephropathy. Proc Soc Exp Biol Med 183:348-357, 1986. Abrass CK: Evaluation of sequential glomerular eluates from rats with Heymann nephritis. J Immunol 137:530-535, 1986. Couser WG, Abrass C, Ochi R, Adler S, Johnson R: Mechanisms of glomerular injury in immune complex disease. Kidney Int 28:569-583, 1985. Abrass, CK: Glomerulonephritis in the elderly. Amer J Nephrol 5:409-418, 1985. Abrass CK, O'Connor S, Scarpace P, Abrass IB: Characterization of the β-adrenergic receptor of rat peritoneal macrophages. J Immunol 135:1338-1341, 1985. Abrass CK, Hori, M: Alterations in macrophage Fc receptor function in rats with streptozotocin‑induced diabetes. J Immunol 133:1307-1312, 1984. Abrass, CK: Diabetic Proteinuria: Glomerular or tubular in origin? Amer J Nephrol 4:337-346, 1984. Abrass CK: Evaluation of the presence of circulating immune complexes and their relationship to glomerular IgG deposits in streptozotocin‑induced diabetic rats. Clin Exp Immunol 57:17-21, 1984. Abrass CK: Autologous immune complex nephritis in rats: Influence of modification of mononuclear‑phagocyte system function. Lab Invest 51:162-171, 1984. Abrass CK, Davidson WD, Guziel L, Grinnell V: Therapeutic renal artery occlusion with a detachable balloon. Amer J Nephrol 4:317-321, 1984. Kenney HM, Weisbart RH, Colburn KK, Abrass CK, Barnett EV, Golde DW: Immune complexes from patients with connective tissue disease prevent neutrophils from responding to a lymphokine. Infection and Immunity 42:876-881, 1983. Abrass CK, Heber D, Lieberman J: Circulating immune complexes in patients with diabetes mellitus. Clin Exp Immunol 52:164-172, 1983. Abrass CK, McVay J, Glassock RJ: Evaluation of homologous and isologous passive Heymann nephritis: Influence on endogenous antibody production. J Immunol 130:195-202, 1983. Abrass CK, Nies KM, Louie JS, Border WA, Glassock RJ: Correlation and predictive accuracy of circulating immune complexes with disease activity in patients with systemic lupus erythematosus. Arthritis Rheum 23:273-282, 1980. Abrass CK, Border WA, Hepner G: Nonspecificity of circulating immune complexes in patients with acute and chronic liver disease. Clin Exp Immunol 40:292-298, 1980. Abrass CK, Hall CL, Border WA, Brown CA, Glassock RJ, Coggins CH: Circulating immune complexes in adults with idiopathic nephrotic syndrome: Relationship to histologic category and clinical course. Kidney Int 17:545-553, 1980. Abrass CK, Border WA, Glassock RJ: Circulating immune complexes in rats with autologous immune complex nephritis. Lab Invest 43:18-27, 1980. Barnett EV, Knutson DW, Abrass CK, Chia D, Young LS, Liebling MR: Circulating immune complexes: Their immunochemistry, detection and importance. Ann Intern Med 91:430-440, 1979. Louie JS, Nies KM, Shoji KT, Fraback RC, Abrass CK, Border WA, Cherry JD, Imagawa D: Clinical and antibody responses following influenza immunization in systemic lupus erythematosus. Ann Intern Med 88:790-792, 1978. Klaus MH, Jerauld R, Kreger NC, McAlpine W, Steffa M, Kennel JH: Maternal attachment: Importance of first post‑partum days. N Engl J Med 286:460-463, 1972. Stenchever MA, Kreger NC: Effect of selected estrogens and progestins on human chromosomes in-vitro. Obstet Gynecol 34:249‑251, 1969.
	Books and Book Chapters
	Abrass CK: Kidney Disease in Diabetes. In, The Encyclopedia of Endocrinology and Endocrine Diseases. Ed. L Martini, Academic Press, San Diego, CA, 2002. Abrass CK: Mechanisms of immune complex formation and deposition in renal structures. In: Immunologic Renal Diseases. Ed. by EG Neilson and WG Couser. Second Edition, Lippincott-Raven Press, New York, NY, Chapter 14, pp. 277-295, 2001. Abrass CK: Immune Complex Diseases. In: Textbook of Nephrology, SG Massry, RJ Glassock (Eds), Fourth Edition, Lippincott, Williams & Wilkins, Philadelphia, PA, Chapter 36, Pt 3, pp. 576-583, 2001. Abrass CK: Renal Disease in the Elderly. In: Current Practice of Medicine, Roger Bone (Ed). Third edition, Churchill Livingstone, New York, 2000. Abrass CK, Preisig P (Guest Eds): Women In Nephrology, In: Seminars In Nephrology, NA Kurtzman (Ed), WB Saunders Co., Philadelphia, PA, March (vol 19), 1999. Abrass CK: Renal Disease in the Elderly. In: Current Practice of Medicine, Roger Bone (Ed). Second edition, Churchill Livingstone, New York, 1999. Abrass CK: Mechanisms of immune complex formation and deposition in renal structures. In: Immunologic Renal Diseases. Ed. by EG Neilson and WG Couser. Lippincott-Raven Press, New York, NY, chapt. 14, pp. 291-307, 1997. Abrass CK: Renal Disease in the Elderly. In: Current Practice of Medicine, Roger Bone (Ed). Churchill Livingstone, New York, chapt. XV:26, pp. 26.1-26.6., 1996. Abrass CK: Immune Complex Diseases. In: Textbook of Nephrology, SG Massry, RJ Glassock (Eds), Third Edition, Williams & Wilkins, Baltimore, MD, chapt. 39, part 3, 635-643, 1995. Zager RA, Abrass CK: Dysproteinemias and the Kidney. In: Textbook of Internal Medicine, M Kelley (Ed), Second Edition, JB Lippincott Co, Philadelphia, PA, Chapter 115, pp 727-730, 1992. Abrass CK: Glomerulonephritis in the Elderly. In: The Principles and Practice of Nephrology, Jacobson HR, Striker GE & Klahr S (Eds), BC Decker, Inc., Philadelphia, chapt 55, pp 339-341, 1991. Couser WG, Abrass CK: Pathogenesis of Membranous Nephropathy, Annual Reviews of Medicine 39:517-530, 1988. Zager RA, Abrass CK: Dysproteinemias and the Kidney. In: Textbook of Internal Medicine, WM Kelley (Ed), pg 781-784, JB Lippincott Co, Philadelphia, PA, 1989. Abrass CK: Circulating Immune Complex Diseases. In: Textbook of Nephrology, SG Massry, RJ Glassock (Eds), pg 562-571, Second Edition, Williams & Wilkins, Baltimore, MD, 1989. Abrass CK, Border WA, Glassock RJ: The Pathogenesis of Autologous Immune Complex Glomerulonephritis in Rats. In: Immune Mechanisms in Renal Disease, Ed by: NB Cummings, AF Michael, CB Wilson, pg 337-348, Plenum Medical Book Company, NY, 1983. Border WA, Abrass CK, Knutson D: Immune Complex Diseases. In: Textbook of Nephrology, SG Massry, RJ Glassock (Eds). First Edition, Williams & Wilkins, Baltimore, MD, 1983 Chapter 35, pg 5.12-5.20. Glassock RJ, Abrass CK, Border WA: Immunological mechanisms and circulating immune complexes in glomerulonephritis. In: Progress in Glomerulonephritis. P. Kincaid‑Smith, AJF d'Apice, RC Atkins (Eds). New York, John Wiley and Sons, 1979. Chapter 2, 27-50.